Results 141 to 150 of about 10,672 (180)

Sensight enables quantitative multivariate engineering of high-performance chemical imaging tools. [PDF]

Nat Commun
Wen C, Jiang Y, Shen T, Jiang X, Fan S, Yang T, Liu X, Luo Q, Li X.   +8 more
europepmc   +1 more source

Nanoparticle to Nanoparticle Bioorthogonal Detection of Atherosclerosis. [PDF]

ACS Appl Mater Interfaces
Muñoz-Hernando M, Nogales P, Rodríguez-San Pedro A, Ibañez M, Morcillo MÁ, González-Cintado L, Bentzon JF, Herranz F.   +7 more
europepmc   +1 more source

Combined Inductive and Dispersion Effects Enhance Bioorthogonal Reactivity of Tetrazines Toward Isonitriles. [PDF]

Angew Chem Int Ed Engl
Biswas S, Löffler A, Bansal P, Peterson RT, Svatunek D, Franzini RM.   +5 more
europepmc   +1 more source

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Bioorthogonal Reactions Utilizing Nitrones as Versatile Dipoles in Cycloaddition Reactions

Chemical Reviews, 2021
Bioorthogonal chemical reactions have emerged as convenient and rapid methods for incorporating unnatural functionality into living systems. Different prototype reactions have been optimized for use in biological settings. Optimization of 3 + 2 dipolar cycloadditions involving nitrones has resulted in highly efficient reaction conditions for ...
Didier A. Bilodeau, Kaitlyn D. Margison, Mariam Serhan, John Paul Pezacki   +3 more
openaire   +4 more sources

Mechanisms and Substituent Effects of Metal-Free Bioorthogonal Reactions

Chemical Reviews, 2021
Reactions that occur under physiological conditions find diverse uses in the chemical and biological sciences. However, the limitations that biological systems place on chemical reactions restrict the number of such bioorthogonal reactions. A profound understanding of the mechanistic principles and structure-reactivity trends of these transformations ...
Titas Deb, Julian Tu, Raphael M. Franzini   +2 more
openaire   +4 more sources

Bioorthogonal Click and Release Reaction of Iminosydnones with Cycloalkynes

Angewandte Chemie, 2017
AbstractWe report the discovery of a new bioorthogonal click‐and‐release reaction involving iminosydnones and strained alkynes. This transformation leads to two products resulting from the ligation and fragmentation of iminosydnones under physiological conditions. Optimized iminosydnones were successfully used to design innovative cleavable linkers for
Bernard, Sabrina, Audisio, Davide, Riomet, Margaux, Bregant, Sarah, Sallustrau, Antoine, Plougastel, Lucie, Decuypere, Elodie, Gabillet, Sandra, Kumar, Ramar Arun, Elyian, Jijy, Trinh, Minh Nguyet, Koniev, Oleksandr, Wagner, Alain, Kolodych, Sergii, Taran, Frédéric   +14 more
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Photo-activatable Reagents for Bioorthogonal Ligation Reactions

Topics in Current Chemistry, 2023
Light-induced bioorthogonal reactions offer spatiotemporal control over selective biomolecular labeling. This review covers the recent advances in the design of photo-activatable reagents for bioorthogonal conjugation reactions in living systems.
Heyang, Zhang, Ming, Fang, Qing, Lin
openaire   +2 more sources

Dissociative Bioorthogonal Reactions

ChemBioChem, 2019
AbstractBioorthogonal reactions that proceed readily under physiological conditions without interference from biomolecules have found widespread application in the life sciences. Complementary to the bioorthogonal reactions that ligate two molecules, reactions that release a molecule or cleave a linker are increasingly attracting interest.
Julian Tu, Minghao Xu, Raphael M. Franzini   +2 more
openaire   +2 more sources

Building better bioorthogonal reactions

Current Opinion in Chemical Biology, 2014
Over the past two decades, there has been intense interest in designing and implementing selective (bioorthogonal) reactions for biomolecule tracking. Here we review the most widely used bioorthogonal chemistries in live cells and animals, drawing particular attention to the unique functional groups underlying these transformations.
Hui-Wen, Shih, David N, Kamber, Jennifer A, Prescher   +2 more
openaire   +2 more sources