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Bioorthogonal Reactions for Bioactive Sulfur Species Delivery
ChemBioChemBioorthogonal chemistry has emerged as a powerful tool for the development of controllable drug delivery systems. Bioactive sulfur species, which participate in complex sulfur signaling pathways, play crucial roles in various physiological and pathological processes.
Yinghan Chen, Lixin Xu, Yong Liang
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Insights Towards Optimizing Palladium-Catalyzed Bioorthogonal Reactions
2021Despite large amounts of research investigating the mechanism and kinetics of the Suzuki-Miyaura reaction in organic solvent, very little research has been completed to investigate this mechanism or kinetic properties in aqueous solvent. Due to properties of the Suzuki-Miyaura reaction which are favourable to bioorthogonal reaction, I first ...
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Three-Component Bioorthogonal Reactions on Cellular DNA and RNA
Bioconjugate Chemistry, 2019Metabolic incorporation of bioorthogonal functional groups into chromatin, followed by copper-free conjugation reactions, often gives low yields due to steric hindrance. Here we report that a cationic Sondheimer diyne derivative "DiMOC" rapidly reacts with azide groups in duplex DNA that are otherwise unreactive toward aliphatic cyclooctynes such as ...
Masayuki Tera, Nathan W. Luedtke
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Tumor AcidityâTriggered Bioorthogonal Reactions for Biomedical Applications
ChemBioChemAbstractCancer is one of the most serious threats to human health. Over the past few years, researchers have incrementally uncovered the pivotal role of tumor acidity in tumor formation, development, and treatment. In addition, bioorthogonal reactions have been widely used in tumor diagnosis and therapy, owing to their advantageous characteristics ...
Xiajian Liu, Ihsan Ullah, Youyong Yuan
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Bioorthogonal Reaction for Fluorine-18 Labeling
2018Specific molecular imaging probes including radiopharmaceuticals labeled with positron-emitters, such as fluorine-18 (18F, t1/2 = 109.8 min), need to expand their applications of positron emission tomography (PET) molecular imaging study. In recent years, bioorthogonal chemistry such as inverse electron-demand Diels-Alder cycloaddition reactions and ...
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Metal complex catalysts broaden bioorthogonal reactions
Science China Chemistry, 2023Hanjie Zhang +4 more
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Developing bioorthogonal probes to span a spectrum of reactivities
Nature Reviews Chemistry, 2020Sean S Nguyen, Jennifer A Prescher
exaly
Hydrogen-bonded organic framework-based bioorthogonal catalysis prevents drug metabolic inactivation
Nature Catalysis, 2023Chuanqi Zhao, Xiaogang Qu, Jinsong Ren
exaly