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A Comparative Study of Bioorthogonal Reactions with Azides
ACS Chemical Biology, 2006Detection of metabolites and post-translational modifications can be achieved using the azide as a bioorthogonal chemical reporter. Once introduced into target biomolecules, either metabolically or through chemical modification, the azide can be tagged with probes using one of three highly selective reactions: the Staudinger ligation, the Cu(I ...
Nicholas J. Agard +4 more
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Bioorthogonal Reactions for Bioactive Sulfur Species Delivery
ChemBioChemBioorthogonal chemistry has emerged as a powerful tool for the development of controllable drug delivery systems. Bioactive sulfur species, which participate in complex sulfur signaling pathways, play crucial roles in various physiological and pathological processes.
Yinghan Chen, Lixin Xu, Yong Liang
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Inverse Electron-Demand Diels–Alder Bioorthogonal Reactions
Topics in Current Chemistry, 2015Bioorthogonal reactions have been widely used over the last 10 years for imaging, detection, diagnostics, drug delivery, and biomaterials. Tetrazine reactions are a recently developed class of inverse electron-demand Diels-Alder reactions used in bioorthogonal applications.
Haoxing, Wu, Neal K, Devaraj
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Three-Component Bioorthogonal Reactions on Cellular DNA and RNA
Bioconjugate Chemistry, 2019Metabolic incorporation of bioorthogonal functional groups into chromatin, followed by copper-free conjugation reactions, often gives low yields due to steric hindrance. Here we report that a cationic Sondheimer diyne derivative "DiMOC" rapidly reacts with azide groups in duplex DNA that are otherwise unreactive toward aliphatic cyclooctynes such as ...
Masayuki Tera, Nathan W. Luedtke
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Development and application of bond cleavage reactions in bioorthogonal chemistry
Nature Chemical Biology, 2016Bioorthogonal chemical reactions are a thriving area of chemical research in recent years as an unprecedented technique to dissect native biological processes through chemistry-enabled strategies. However, current concepts of bioorthogonal chemistry have largely centered on 'bond formation' reactions between two mutually reactive bioorthogonal handles.
Jie, Li, Peng R, Chen
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Bioorthogonal Reaction for Fluorine-18 Labeling
2018Specific molecular imaging probes including radiopharmaceuticals labeled with positron-emitters, such as fluorine-18 (18F, t1/2 = 109.8 min), need to expand their applications of positron emission tomography (PET) molecular imaging study. In recent years, bioorthogonal chemistry such as inverse electron-demand Diels-Alder cycloaddition reactions and ...
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Target-Specific Bioorthogonal Reactions for Precise Biomedical Applications
Angewandte Chemie - International Edition, 2023Jinsong Ren, Xiaogang Qu, Mengyu Sun
exaly
Development of new bioorthogonal ligation reactions
Développement de nouvelles réactions de ligation bioorthogonales Le principal objectif de cette thèse a consisté au développement d’une méthode de screenning pour la découverte de nouvelles réactions de ligations bioorthogonales ainsi que son application sur une bibliothèque développée pour cette étude.openaire +1 more source
Fluorescent Probes Based on Bioorthogonal Reactions: Construction Strategies and Applications
TrAC - Trends in Analytical Chemistry, 2023Jianzhong Lu, Hanqing Zhao, Yingtung Lo
exaly
Increasing the Efficacy of Bioorthogonal Click Reactions for Bioconjugation: A Comparative Study
Angewandte Chemie - International Edition, 2011Yi Liu, Peng Wu
exaly