Results 61 to 70 of about 39,175 (290)

New amphiphilic amino acid derivatives for efficient DNA transfection in vitro [PDF]

open access: yes, 2017
Nucleic acids-based therapies have recently developed as next-generationagents for treating and preventing viral infection, cancer, and genetic disorders,but their use is still limited due to its relatively poor delivery into targetedcells.
Antuña, Sebastián   +7 more
core   +1 more source

Safety and Biopharmaceutical Challenges of Excipients in Off-Label Pediatric Formulations

open access: yesInternational Journal of General Medicine, 2020
Anteneh Belayneh,1 Ebisa Tadese,2 Fantahun Molla2 1Department of Pharmacy, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia; 2Department of Pharmaceutics, School of Pharmacy, College of Health Sciences, Mekelle University ...
Belayneh A, Tadese E, Molla F
doaj  

Optimization of tetramycin production in Streptomyces ahygroscopicus S91

open access: yesJournal of Biological Engineering, 2021
Background Tetramycin is a 26-member tetraene antibiotic used in agriculture. It has two components, tetramycin A and tetramycin B. Tetramycin B is obtained by the hydroxylation of tetramycin A on C4.
Guang Chen   +3 more
doaj   +1 more source

Continuous Suppression of Pathological Retinal and Choroidal Neovascularization in Cynomolgus Monkeys via Noninvasive Ophthalmic Delivery of a Novel Anti‐VEGFA Nanobody and Proprietary Penetratin Analog Formulation

open access: yesAdvanced Science, EarlyView.
Pathological retinal/choroidal neovascularization drives vision loss in DR and AMD. Current anti‐VEGF injections, while effective, require invasive, frequent administration. Pene/LQ015, is developed a novel topical anti‐VEGFA nanobody formulation achieving therapeutic intraocular levels through penetratin analog‐enhanced delivery.
Chong Chen   +12 more
wiley   +1 more source

Multiple Elements in Single Words [PDF]

open access: yes, 2019
What\u27s the shortest word from which the names of 2 chemical elements can be spelled ...
Francis, Darryl
core   +1 more source

Complexation between oleanolic and maslinic acids with native and modified cyclodextrins [PDF]

open access: yes, 2018
Oleanolic (OA) and maslinic (MA) acids are two natural triterpenoids with a wide range of beneficial effects for human health. However, their low solubility and permeability make their application in the food or industry difficult. The complexation of OA
López Miranda, Santiago
core   +2 more sources

Three-dimensional Biopharmaceutics and Clinical Considerations of Drugs for Safety and Efficacy: A Review Study [PDF]

open access: yesPharmaceutical and Biomedical Research
Background: Several drugs today are described with their molecular structures showcasing symmetrical, dissymmetrical, or asymmetrical configurations. Some drugs showing chirality are racemic or pure enantiomeric forms for clinical practice.
Sunday O. Awofisayo   +3 more
doaj  

Biological and Biosimilar Medicines in Contemporary Pharmacotherapy for Metabolic Syndrome

open access: yesPharmaceutics
The discovery of new drugs offers valuable alternatives, particularly for treating diseases that are resistant to existing therapies or involving complex, multi-organ conditions such as metabolic syndrome. Although treatment algorithms are generally well
Wiktoria Górecka   +4 more
doaj   +1 more source

A Hypoxia‐Responsive Single‐Atom Sonozyme for Targeted Sonocatalytic Therapy in Alleviating Atherosclerotic Plaque

open access: yesAdvanced Science, EarlyView.
A tetranitrogen‐coordinated single‐atom manganese catalyst (SMC) is fabricated with outstanding sonosensitization efficiency and multi‐enzyme‐like catalytic properties. To enable better targeting of M1 macrophages, hyaluronic acid (HA) is applied to modify the surface of SMC, yielding SMC‐HA nanozymes.
Qiaofei Chen   +14 more
wiley   +1 more source

Dual antibiotherapy of tuberculosis mediated by inhalable locust bean gum microparticles [PDF]

open access: yes, 2017
Despite the existence of effective oral therapy, tuberculosis remains a deadly pathology, namely because of bacterial resistance and incompliance with treatments.
Alves, Ana D.   +7 more
core   +1 more source

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