Results 131 to 140 of about 2,756 (173)
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Physiological and clinical chemistry of biopterin
Medicinal Research Reviews, 1989Chimie, dosage de la biopterine. Biosynthese de la tetrahydrobiopterine. Role physiologique de la tetrahydrobiopterine comme cofacteur des monooxygenases necessitant la pterine.
T, Nagatsu, S, Matsuura, T, Sugimoto
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Psychiatric Manifestations in Patients with Biopterin Defects
Neuropediatrics, 2022AbstractPsychiatric manifestations in patients with tetrahydrobiopterin (BH4) defects are common, and may occur even with treatment of the underlying disorder. The neurobiological background of these conditions has been linked to abnormalities of neurotransmitters, such as dopamine, serotonin, norepinephrine, and gamma-aminobutyric acid.
Maksim Parfyonov +4 more
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Biopterin and neopterin in human saliva
Life Sciences, 1989Presence of biopterin and neopterin in human saliva was investigated by HPLC after iodine oxidation in acidic medium. Concentrations of biopterin and neopterin (M +/- SEM) were 1.271 +/- 0.254 and 0.358 +/- 0.075 ng per ml, respectively, in saliva of apparently healthy young male adults, ages 20 to 22 years (n = 9).
S, Katoh +3 more
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Neurochemical Research, 1981
Repeated intraventricular injections of 2,4-diamino-6-hydroxypyrimidine (DAO-Pyr), inhibitor of D-erythro-q-dihydroneopterin triphosphate synthetase, inhibited q-BH2 synthesis from GTP, markedly increased accumulation of 2-amino-4-hydroxy-5 (or -6)-formamido-6-triphosphoribosylaminopyrimidine (FPyd-P3) and brought about a 60% decrease in the in vivo of
E M, Gál, D H, Whitacre
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Repeated intraventricular injections of 2,4-diamino-6-hydroxypyrimidine (DAO-Pyr), inhibitor of D-erythro-q-dihydroneopterin triphosphate synthetase, inhibited q-BH2 synthesis from GTP, markedly increased accumulation of 2-amino-4-hydroxy-5 (or -6)-formamido-6-triphosphoribosylaminopyrimidine (FPyd-P3) and brought about a 60% decrease in the in vivo of
E M, Gál, D H, Whitacre
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Screening for Biopterin Disorders in PKU
Pediatrics, 1980It is now recognized (Pediatrics 65:806, 1980) that a small proportion of cases of phenylketonuria (PKU) may be due to abnormalities in the metabolism of biopterin. These cases do not respond to the restriction of dietary phenylalanine, but may be benefited by neurotransmitter replacement therapy. A specific diagnosis is therefore desirable.
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ChemInform Abstract: PTERIDINES, LXXV. SYNTHESIS AND PROPERTIES OF BIOPTERIN AND BIOPTERIN ANALOGS
Chemischer Informationsdienst, 1985AbstractAus dem Desoxy‐arabinose‐hydrazon (II) und den Diaminen ( l) werden Biopterin ( 111a), dessen Dimethyl‐Derivat (IIIc) und Biolumazin (IIIb) hergestellt.
M. KAPPEL, R. MENGEL, W. PFLEIDERER
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Journal of the Chemical Society C: Organic, 1969
An unambiguous synthesis of biopterin [2-amino-6-(L-erythro-1,2-dihydroxypropyl)pteridin-4-(3H)-one] is described; based on an improved synthesis of L-neopterin. The synthesis yields biopterin, a naturally occurring pteridine, in a pure, crystalline form without recourse to chromatography. D-Biopterin and D-neopterin are also described.
K. J. M. Andrews +2 more
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An unambiguous synthesis of biopterin [2-amino-6-(L-erythro-1,2-dihydroxypropyl)pteridin-4-(3H)-one] is described; based on an improved synthesis of L-neopterin. The synthesis yields biopterin, a naturally occurring pteridine, in a pure, crystalline form without recourse to chromatography. D-Biopterin and D-neopterin are also described.
K. J. M. Andrews +2 more
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Biopterin metabolism in patients with malignant syndrome
Parkinsonism & Related Disorders, 2003We examined the autopsied brains of two parkinsonian patients who had malignant syndrome (MS). Neopterin and biopterin contents, and GTP cyclohydrolase I activity were measured in various region of the brain. We found relatively higher GTP cyclohydrolase I activities in the hypothalamus compared with other regions of the brain from patients with MS ...
H. Ichinose +7 more
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Biopterin cofactor and monoamine-synthesizing monooxygenases
Neurochemistry International, 1983The activities of three pterin-requiring monooxygenases, phenylalanine hydroxylase, tyrosine hydroxylase and tryptophan hydroxylase, are regulated by the level of the pterin cofactor, (6R)- l -erythro- tetrahydrobiopterin , which is synthesized from guanosine triphosphate (GTP).
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Pteridine, LXXV. Synthese und Eigenschaften von Biopterin und Biopterin‐Analogen
Liebigs Annalen der Chemie, 1984AbstractDie Synthese von Biopterin (6), seinem 2‐N,N‐Dimethyl‐ (8) und 4‐ Thioxo‐Derivat (19) sowie von Biolumazin (7) wird beschrieben. Durch Umsetzung von Biopterin mit α‐Acetoxyisobuttersäurechlorid läß sich die Seitenkette zu 6‐(L‐threo‐2‐Acetoxy‐1‐chlorpropyl)pterin (10) modifizieren, das als Ausgangsmaterial fär weitere Derivatisierungen dienen ...
Mathias Kappel +2 more
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