Results 31 to 40 of about 1,078 (162)

Attenuating susceptibility to ascites in cold‐stressed broiler chickens fed canola meal‐based diets by supplementing arginine or guanidinoacetic acid, either alone or in combination with phenylalanine

Veterinary Medicine and Science, Volume 10, Issue 6, November 2024.
For ARG subscript: Decreased ascites mortality by increased plasma nitric oxide (NO), decreased RV:TV ratio and improved blood oxygen levels. For PHE subscript: Improved feed conversion ratio and decreased ascites susceptibility when combined with ARG or GAA.
Negin Delfani, Mohsen Daneshyar, Parviz Farhoomand, Sina Payvastegan, Younes Ali Alijoo, Gholamreza Najafi   +5 more
wiley   +1 more source

An Efficient Synthesis of 2'-O-(β-D-Ribofuranosyl)biopterin [PDF]

, 2008
N(2)-(N,N-Dimethylaminomethylene)-3-[2-(4-nitrophenyl)ethyl]-1',2'-di-O (trimethylsilyl)biopterin (4) was prepared from biopterin (1a, 86% overall yield) in 5 steps. Glycosylation of 4 with 1,2,3,5-tetra-O-acetyl-β D-ribofuranose (5a) and its 2,3,5-tri-O-
Fujita, Hiroshi, Hanaya, Tadashi, Pfleiderer, Wolfgang, Soranaka, Kazuyuki, Torigoe, Kiyoshi, Yamamoto, Hiroshi   +5 more
core   +1 more source

Comparative analysis of gene and disease selection in genomic newborn screening studies

Journal of Inherited Metabolic Disease, Volume 47, Issue 5, Page 945-970, September 2024.
Abstract Genomic newborn screening (gNBS) is on the horizon given the decreasing costs of sequencing and the advanced understanding of the impact of genetic variants on health and diseases. Key to ongoing gNBS pilot studies is the selection of target diseases and associated genes to be included.
Isabel R. Betzler, Maja Hempel, Ulrike Mütze, Stefan Kölker, Eva Winkler, Nicola Dikow, Sven F. Garbade, Christian P. Schaaf, Heiko Brennenstuhl   +8 more
wiley   +1 more source

Redox sensor and effector functions of tetrahydrobiopterin and the mitochondria in molecular models of cardiovascular disease [PDF]

, 2018
Tetrahydrobiopterin (BH4) is a redox active molecule that is essential for the production of nitric oxide (NO) by the NO synthase (NOS) enzymes. Loss of endothelial BH4 leads to decreased NO and increased superoxide generation by endothelial NOS (eNOS ...
Bailey, Jade
core   +1 more source

Endothelial cell tetrahydrobiopterin deficiency attenuates LPS-induced vascular dysfunction and hypotension [PDF]

, 2015
Overproduction of nitric oxide (NO) is thought to be a key mediator of the vascular dysfunction and severe hypotension in patients with endotoxaemia and septic shock. The contribution of NO produced directly in the vasculature by endothelial cells to the
Channon, Keith M., Chuaiphichai, Surawee, McNeill, Eileen, Nandi, Manasi, Starr, Anna   +4 more
core   +2 more sources

Endothelial histone deacetylase 1 activity impairs kidney microvascular NO signaling in rats fed a high‐salt diet

Acta Physiologica, Volume 240, Issue 9, September 2024.
Abstract Aim We aimed to test the hypothesis that a high‐salt diet (HS) impairs NO signaling in kidney microvascular endothelial cells through a histone deacetylase 1 (HDAC1)‐dependent mechanism. Methods Male Sprague Dawley rats were fed normal salt diet (NS; 0.49% NaCl) or HS (4% NaCl) for 2 weeks. NO signaling was assessed by measuring L‐NAME induced
Luke S. Dunaway, Anthony K. Cook, Cailin E. Kellum, Claudia Edell, Davide Botta, Patrick A. Molina, Randee S. Sedaka, Livius V. d'Uscio, Zvonimir S. Katusic, David M. Pollock, Edward W. Inscho, Jennifer S. Pollock   +11 more
wiley   +1 more source

Is allostery a fuzzy concept?

FEBS Open Bio, Volume 14, Issue 7, Page 1040-1056, July 2024.
Assigning a reaction mechanism to allosteric proteins can be difficult. It is also unclear how many reaction mechanisms qualify as allosteric and the criteria used for assigning such mechanisms. Here, we define these criteria, apply them to a list of allosteric proteins, and suggest that reaction mechanism assignment should be considered preliminary ...
Veronica Morea, Francesco Angelucci, Andrea Bellelli   +2 more
wiley   +1 more source

GV‐971 attenuates the progression of neuromyelitis optica in murine models and reverses alterations in gut microbiota and associated peripheral abnormalities

CNS Neuroscience &Therapeutics, Volume 30, Issue 7, July 2024.
The NMOSD model demonstrated substantial neuroinflammation and neural injury, accompanied by imbalances in gut microbiota, peripheral inflammation, and metabolic disorders, suggesting a potentially vicious cycle that exacerbates disease pathogenesis.
Xinying Yang, Zhongheng Zhangyi, Aisong Yu, Qinming Zhou, Aihua Xia, Ji Qiu, Meixiang Cai, Xingkun Chu, Liang Li, Zhengnan Feng, Zhiyu Luo, Guangqiang Sun, Jing Zhang, Meiyu Geng, Sheng Chen, Zuoquan Xie   +15 more
wiley   +1 more source

Tetrahydrobiopterin (BH4) treatment stabilizes tyrosine hydroxylase: Rescue of tyrosine hydroxylase deficiency phenotypes in human neurons and in a knock‐in mouse model

Journal of Inherited Metabolic Disease, Volume 47, Issue 3, Page 494-508, May 2024.
Abstract Proteostatic regulation of tyrosine hydroxylase (TH), the rate‐limiting enzyme in dopamine biosynthesis, is crucial for maintaining proper brain neurotransmitter homeostasis. Variants of the TH gene are associated with tyrosine hydroxylase deficiency (THD), a rare disorder with a wide phenotypic spectrum and variable response to treatment ...
Kunwar Jung‐KC, Alba Tristán‐Noguero, Altanchimeg Altankhuyag, David Piñol Belenguer, Karina S. Prestegård, Irene Fernandez‐Carasa, Arianna Colini Baldeschi, Maria Sigatulina Bondarenko, Angeles García‐Cazorla, Antonella Consiglio, Aurora Martinez   +10 more
wiley   +1 more source

Oxidative Stress and Immune System in Vitiligo and Thyroid Diseases. [PDF]

, 2015
Vitiligo is an acquired dermatological disease frequently associated with autoimmune thyroid disorders. Several theories have been proposed so far to unravel the complex vitiligo pathogenesis.
Colucci, Roberta, Dragoni, Federica, Moretti, Silvia   +2 more
core   +4 more sources