Results 131 to 140 of about 44,737 (248)

Evaluation of a high throughput multiparallel stirred bioreactor system using an apple cell line. [PDF]

Sci Rep
Lillberg A, Guerriero G, Cocco E, Jourdan S, Sergeant K, Renaut J, Pajumo M, Akhgari A, Rischer H, Legay S.   +9 more
europepmc   +1 more source

Screening of bispecific antibodies during single cell cloning of recombinant Chinese hamster ovary cell lines to improve titer and product quality

Biotechnology Progress, EarlyView.
Abstract Development of therapeutic bispecific antibodies (BsAbs) poses significant manufacturability challenges associated with correct chain pairing and an increased diversity of impurities. Here we address this with a product quality assessment during cell line development (CLD), forgoing the need for genetic characterization during cell line ...
Molly Robinson, Jessica Willmott, Holly Corrigall, Daniela Lega, Joseph Stirling, Vithiya Vimalraj, Mitul Patel, Robyn Emmins   +7 more
wiley   +1 more source

Coupled succinic acid fermentation and biogas upgrading enabled by in situ product recovery. [PDF]

Biotechnol Biofuels Bioprod
Zacharopoulos I, Grimalt-Alemany A, Angelidaki I.   +2 more
europepmc   +1 more source

High‐throughput development and scale‐up of recombinant adeno‐associated virus 5 anion‐exchange chromatography for high‐purity capsid separation

Biotechnology Progress, EarlyView.
High‐throughput anion‐exchange chromatography process development enables scalable purification of high‐purity recombinant adeno‐associated virus capsids. Abstract Recombinant adeno‐associated virus (rAAV) production commonly yields a high proportion of empty and partially filled capsids, necessitating downstream purification to enrich full capsids ...
Kevin Vera, Ivan Gajic, Praveen Kusumanchi, Angela Andaluz, Gabrielle Dela Pena, Clifford A. Froelich, Elizabeth Higgins, Jennifer Johnston, Seyed Pouria Motevalian   +8 more
wiley   +1 more source

Evaluation of bone formation within β-tricalcium phosphate scaffolds in a sheep scapular bioreactor model using micro-computed tomography analysis. [PDF]

Regen Biomater
Al Maruf DSA, Darnell M, Ren J, Tomaskovic-Crook E, Cheng K, Lewin W, Kruse HV, Lawrence D, Luo P, Wise IK, Gupta A, Leinkram D, Manzie T, Parthasarathi K, Wykes J, Low H, Froggatt C, McKenzie DR, Wallace G, Crook JM, Clark JR.   +20 more
europepmc   +1 more source

Regenerative perfusion bioreactor for biologics production with lower COGs

Biotechnology Progress, EarlyView.
Abstract Perfusion bioreactor systems enable intensified bioprocessing with high cell densities and volumetric productivities in monoclonal antibody (mAb) manufacturing. However, their widespread adoption remains constrained by the high consumption of chemically defined cell culture media.
Eric Wynne, Dohyun Park, Hourieh Ahi, Jaeweon Lee, Seongkyu Yoon, Jongyoon Han   +5 more
wiley   +1 more source

Bioleaching of GaAs metal hydroxide sludge: a biohydrometallurgical alternative to conventional acid leaching. [PDF]

Front Microbiol
Fritze MT, Haubrich F, Otto A, Schippers A, Hedrich S.   +4 more
europepmc   +1 more source

Economic and environmental implications of the development of UASB reactors in Mexico for sustainable industrial wastewater treatment

The Canadian Journal of Chemical Engineering, EarlyView.
Abstract The objective of this work is to demonstrate that the inclusion of an up‐flow anaerobic sludge bed (UASB reactor) within an industrial wastewater treatment plant reduces the plant's investment and operating costs compared to a system based solely on conventional complete‐mix activated sludge (CMAS), operating under the same design principles ...
Juan Manuel Morgan‐Sagastume, Adalberto Noyola   +1 more
wiley   +1 more source

Production of an enzymatic cocktail by Aspergillus japonicus in a stirred-tank bioreactor for application in animal feed. [PDF]

World J Microbiol Biotechnol
de Oliveira Simas AL, Almeida AP, Glienke NN, de Melo Santana Q, Silva Galeano RM, Kiefer C, de Souza Nascimento KMR, de Moraes Polizeli MLT, Masui DC, Zanoelo FF, Giannesi GC.   +10 more
europepmc   +1 more source

Review of CFD modelling techniques for single‐phase and multiphase flow in static mixers

The Canadian Journal of Chemical Engineering, EarlyView.
This review synthesizes computational fluid dynamics (CFD) approaches for static mixers, linking hydrodynamics to pressure drop, particle/droplet distributions, mixing metrics, and heat‐transfer performance to guide modelling choices and design decisions. Abstract Static mixers enable compact and low‐energy intensification.
Jussan Jaeger, Sálvio Lima de Carvalho Neto, Silvio Edegar Weschenfelder, Glaucia Rodrigues Vieira de Almeida da Fonseca, Maria de Fátima Rodrigues da Cunha, Selene Maria Arruda Guelli Ulson de Souza, Evandro Balestrin, Adriano da Silva   +7 more
wiley   +1 more source