Results 101 to 110 of about 4,221 (165)

Integrating Experimental Physicochemical Data with PBPK Modeling to Guide the Translational Development of the Antifungal 1,3,4-Oxadiazole Derivative LMM6. [PDF]

ACS Omega
Piai JMB, Lippa VNM, Caleffi-Marchesini ER, Borghi Pangoni FB, Felipe MS, Kioshima ES, Diniz A.   +6 more
europepmc   +1 more source

Prediction of food effects on the absorption of celecoxib based on biorelevant dissolution testing coupled with physiologically based pharmacokinetic modeling

, 2009
Since the rate-determining step to the intestinal absorption of poorly soluble drugs is the dissolution in the gastrointestinal (GI) tract, postprandial changes in GI physiology, in addition to any specific interactions between drug and food, are ...
Mao, Y., Janssen, N., Vertzoni, M., Reppas, C., Shono, Y., Dressman, J.B., Kesisoglou, F., Jantratid, E.   +7 more
core  

A Combined Experimental and Predictive Modeling Study of Diltiazem Release From Natural Polymer Microcapsules in Different Media. [PDF]

CPT Pharmacometrics Syst Pharmacol
Üstün Z, Kara Ü.
europepmc   +1 more source

Development of a biorelevant methodology for drug release in the mouth [PDF]

The oral route is the most popular and convenient route for drug administration. There are a growing number of alternative solid oral dosage forms that have been developed for more specialised drug delivery compared to monolithic solid oral dosage forms.
Ali, Joseph
core  

Nickel catalysis enables chemoselectivity in radiation chemistry. [PDF]

Nat Commun
Liang W, Wu C, Li J, Xu Y, Liu X, Sang Z, Tu Z, Mu BS, Liu Z.   +8 more
europepmc   +1 more source

An Overview of In Vitro Release Methods for Long-Acting Injectable Products Based on PLGA. [PDF]

Methods Protoc
Lusina Kregar M, Krtalić I, Šagud I.
europepmc   +1 more source

From prediction to performance: <i>In silico</i>-supported formulation of amorphous solid dispersions for PROTAC NX-2127. [PDF]

Int J Pharm X
Stakemeier A, Mild L, Sievers J, Kalasová J, Steffens KE, Kuentz M, Steinebach C, Wagner KG.   +7 more
europepmc   +1 more source

Nanostructured Lipid Carriers as Physicochemical Modulators of Complex Natural Extracts: Release Behavior and Bile-Induced Remodeling in Biorelevant Media. [PDF]

Molecules
Carrasco-Rojas J, Solas-Soto J, Veas-Albornoz R, Lagos CF, Simirgiotis MJ, Arriagada F, Ortiz AC.   +6 more
europepmc   +1 more source

Abiotic formation of nitrile precursors to amino acids and nucleobases in interstellar ice analogues. [PDF]

Chem Sci
Wang J, Inada S, Zhang C, Marks JH, Wang Z, Bergantini A, McAnally M, Eckhardt AK, Kaiser RI.   +8 more
europepmc   +1 more source

A Dynamic Gastrointestinal Mucus Simulator for Biorelevant Assessment of Nutrient Mucopenetration: Effects of Mucus Purification, Calcium, and Soluble Fibers. [PDF]

Foods
Qin Z, Fortner L, Feng J, Udo T, Mummaleti G, Kong F.   +5 more
europepmc   +1 more source