Results 81 to 90 of about 4,221 (165)

Biorelevant in vitro performance testing of orally administered dosage forms - Workshop report

, 2014
Biorelevant in vitro performance testing of orally administered dosage forms has become an important tool for the assessment of drug product in vivo behavior.
Shah, V.P., Yomota, C., Cecil, T.L., Kraemer, J., Barker, A.R., Reppas, C., Friedel, H.-D., Keitel, S., Morris, J.M., Buhse, L.F., Stickelmeyer, M.P., Brown, C.K.   +11 more
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THE FEATURES OF THE PREDICTIVE DISSOLUTION TESTING (REVIEW)

Разработка и регистрация лекарственных средств, 2019
Dissolution test plays an important role at different levels of the development and manufacturing drugs as one of the major quality control tools and an integral part of In vitro tests in the study of drug release from the developed dosage forms. Article
R. I. Moustafine, A. V. Sitenkova (Bukhovets), N. Fotaki   +2 more
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α-Aminophosphonates: Effective carriers for the membrane transport of biorelevant species

, 2020
The novel lipophilic α-aminophosphonates were synthesized by the Kabachnik-Fields reaction. These compounds exhibited remarkable selectivity as carriers for the membrane transport of the biorelevant species such as α-amino and α-hydroxy ...
Stoikov I., Antipin I., Konovalov A.
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Development of a biorelevant methodology for drug release in the mouth [PDF]

, 2020
The oral route is the most popular and convenient route for drug administration. There are a growing number of alternative solid oral dosage forms that have been developed for more specialised drug delivery compared to monolithic solid oral dosage forms.
Ali, Joseph
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A COMPARATIVE STUDY OF DRUG RELEASE FROM POLYCOMPLEX MATRICES IN STANDARD AND BIORELEVANT MEDIA USING USP III AND USP IV APPARATUS

Разработка и регистрация лекарственных средств, 2019
The results of Indomethacin release from the oral drug delivery systems based on interpolymer complexes with Eudragit® copolymers are presented.
A. V. Sitenkova (Bukhovets), N. Fotaki, R. I. Moustafine   +2 more
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Electrochemical C−H deuteration of pyridine derivatives with D2O

Nature Communications
Herein, we develop a straightforward, metal-free, and acid-/base-free electrochemical C4-selective C − H deuteration of pyridine derivatives with economic and convenient D2O at room temperature.
Zhiwei Zhao, Ranran Zhang, Yaowen Liu, Zile Zhu, Qiuyan Wang, Youai Qiu   +5 more
doaj   +1 more source

The impact of reduced gastric acid secretion on dissolution of salts of weak bases in the fasted upper gastrointestinal lumen: Data in biorelevant media and in human aspirates

, 2017
Purpose To propose media for simulating the intragastric environment under reduced gastric acid secretion in the fasted state at three levels of simulation of the gastric environment and evaluate their usefulness in evaluating the intragastric ...
Litou, C., Vertzoni, M., Reppas, C., Xu, W., Kesisoglou, F.   +4 more
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A Comprehensive Study of Solid Lipid Microparticles (SLMs) Behavior in Biorelevant Dissolution Media

, 2013
The aim of this research was to study the release performance of solid lipid microparticles (SLMs) in various biorelevant dissolution media simulating the conditions of the gastric tract and the proximal human intestine.
DI SABATINO, MARCELLO, PASSERINI, NADIA, ALBERTINI, BEATRICE   +2 more
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Physiologically Based Absorption Modeling of Salts of Weak Bases Based on Data in Hypochlorhydric and Achlorhydric Biorelevant Media

, 2018
Physiologically based absorption modeling has been attracting increased attention to study the interactions of weakly basic drug compounds with acid-reducing agents like proton-pump inhibitors and H2 blockers.
Vertzoni, M., Reppas, C., Kesisoglou, F.
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Development and validation of method for determination of of Cyclosporine in biorelevant mediums

, 2020
Charles university Faculty of Pharmacy in Hradec Králové Department of Analytical Chemistry Candidate: Matej Tichoň Supervisor: assoc. prof. PharmDr. Ludmila Matysová, Ph.D.
Tichoň, Matej
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