Results 61 to 70 of about 4,221 (165)

Evaluating the fed state impact on drug solubility and absorption : a biorelevant in vitro approach [PDF]

Biopharmaceutics, which studies the relationship between a drug's physical, chemical, biological, and pharmacological properties and its dosage form, is essential for studying and optimising oral formulations.
Silva, Maria Inês
core   +2 more sources

BIORELEVANT DISSOLUTION MEDIA: ITS CURRENT STATUS AND FUTUTRE PERSPECTIVES [PDF]

The landscape of dissolution media has been dynamically evolving with newer drugs entering the market among which most of them are either BCS class II or BCS class IV drugs exhibiting poor solubility.
Mehta, Tejal, Hariharan, Kartik, Panchal, Maulik   +2 more
core   +1 more source

Straightforward Access to a Great Diversity of Complex Biorelevant γ-Lactams Thanks to a Tunable Cascade Multicomponent Process

, 2020
The current article reviews the preparation of a great diversity of complex biorelevant γ-lactams backbones thanks to scalable copper(I)-catalyzed cascade multicomponent ...
Parrain, Jean-Luc, Mayooufi, Atef, Thibonnet, Jérôme, Commeiras, Laurent, Mardjan, Muhammad Idham Darussalam   +4 more
core   +2 more sources

The Coordination Chemistry of Bio-Relevant Ligands and Their Magnesium Complexes

Molecules, 2020
The coordination chemistry of magnesium (Mg2+) was extensively explored. More recently; magnesium; which plays a role in over 80% of metabolic functions and governs over 350 enzymatic processes; is becoming increasingly linked to chronic disease ...
Derek R. Case, Jon Zubieta, Robert P. Doyle   +2 more
doaj   +1 more source

Personalized 3D‐Printed Affinisol‐Based Pharmaceutical Delivery Systems: The Case Study for Alternative Sulfonamides for Alzheimer's Disease

Macromolecular Bioscience, Volume 26, Issue 9, September 2026.
Personalized dosage forms engineered via hot‐melt extrusion and FDM 3D‐printing enable the evaluation of novel anti‐Alzheimer's compounds. The study integrates dissolution testing, thermo‐analytical profiling, physico‐chemical characterization, cytotoxicity, and stability to advance personalized medicine in drug development.
Marie Nevyhoštěná, Alena Komersová, Roman Svoboda, Vladimír Pejchal, Adéla Pospíšilová, Jan Muselík, Aleksandra Łapa, Paulina Koczurkiewicz‐Adamczyk   +7 more
wiley   +1 more source

Characterization of biosurfactants’ micelles formation using fluorescence measurements: sodium taurocholate as case of study

ADMET and DMPK
Background and purpose: The evaluation of micellization parameters of surfactants that aggregate gradually, such as bile salts, is not trivial. In this work, different probes and data treatment models are tested to set up an analytical method based on ...
Susana Amézqueta, Elisabet Fuguet, Rubén Cabañas, Clara Ràfols   +3 more
doaj   +1 more source

Oral Delivery Systems for Food‐Derived Bioactive Peptides: Enhancing Stability, Bioavailability, and Health Benefits

Advanced Science, Volume 13, Issue 46, 17 August 2026.
Advanced delivery systems—including nanoparticles, nanoemulsions, liposomes, and hydrogels—protect food‐derived bioactive peptides from gastrointestinal degradation and bitterness. These systems enable pH‐responsive release, enhance intestinal absorption, and improve therapeutic efficacy against oxidative stress, metabolic disorders, cancer, and ...
Yu Xu, Fan Li, Runan Zhao, Tao Shu, Weihong Min, Bei‐Wei Zhu   +5 more
wiley   +1 more source

Image-Based Investigation: Biorelevant Solubility of α and γ Indomethacin [PDF]

, 2019
Solubility is a physicochemical property highly dependent on the solid-state form of a compound. Thus, alteration of a compound’s solid-state form can be undertaken to enhance the solubility of poorly soluble drug compounds.
Sami Svanbäck (1496575), Strachan, Clare J., Jouko Yliruusi (1496578), Svanbäck, Sami, Yliruusi, Jouko, Clare J. Strachan (1877389), Julijana Kristl (2565913), Jernej Štukelj (6417290), Kristl, Julijana, Štukelj, Jernej   +9 more
core   +1 more source

Tensile Stimulation in Biorelevant Culture Conditions Enhances MSC and TPSC Tenogenesis on Aligned Electrospun Scaffolds

Advanced NanoBiomed Research, Volume 6, Issue 8, August 2026.
Biomimetic electrospun scaffold incorporating GDF‐7‐loaded mesoporous silica nanoparticles, combined with mechanical stimulation and physiological oxygen tension, guides tenogenic differentiation of mesenchymal stromal cell and tendon progenitor stem cell. This integrated approach enhances cell proliferation, matrix deposition, and tendon‐specific gene
Vera Citro, Aldo R. Boccaccini, Nicholas R. Forsyth, Tina P. Dale   +3 more
wiley   +1 more source

Biocompatible, Thermoresponsive, and Biodegradable:  Simple Preparation of “All-in-One” Biorelevant Polymers

, 2016
Biocompatible, Thermoresponsive, and Biodegradable:  Simple Preparation of “All-in-One” Biorelevant ...
Jean-François Lutz (2452939), Seema Agarwal (343140), Carsten Rudolph (333357), Julien Andrieu (2175184), Senta Üzgün (2466166)   +4 more
core   +1 more source