Results 61 to 70 of about 6,100 (218)

Dissolution of theophylline from extended-release tablets under cyclic retrograde peristaltic contractions in the Dynamic Colon Model

British Journal of Pharmacy, 2022
The dynamic colon model isa biorelevant in vitro model of the human proximal colon. In vivo, the large intestine mixes its contents using peristaltic waves that propagate both forwards(antegrade) and backwards (retrograde).
Connor O'Farrell, Konstantinos Stamatopoulos , Mark J. H. Simmons, Hannah Batchelor   +3 more
doaj   +1 more source

Modelling the impact of atherosclerosis on drug release and distribution from coronary stents [PDF]

, 2015
Although drug-eluting stents (DES) are now widely used for the treatment of coronary heart disease, there remains considerable scope for the development of enhanced designs which address some of the limitations of existing devices.
A Neubert, A Schiavone, A Seidlitz, A Tan, A Tellez, AD Levin, AR Tzafriri, AR Tzafriri, AR Tzafriri, AV Finn, B Semmling, BE Bierer, C Bernelli, C Yang, C. M. McKittrick, C. McCormick, CC O’Brien, CC O’Brien, CJ Creel, CP Naseerali, CW Hwang, CW Hwang, F Bozsak, G Douglas, G Mani, G Nakazawa, G Vairo, GE Ragkousis, GS Getz, H Hara, H Jia, HJ Kuh, HQ Zhao, IB Menown, J Guo, J Watt, J Wiebe, JF Granada, JL Fan, JM Weiler, K Milewski, K. G. Oldroyd, KB Biggs, KR Kamath, LE Perkins, M Kamberi, M Rattazzi, MA Ewart, MA Lovich, MF Prescott, P Coats, P Zunino, R Mongrain, R Virmani, RS Schwartz, RS Schwartz, S Hossainy, S McGinty, S McGinty, S McGinty, S McGinty, S Morlacchi, S Prabhu, S Simsekyilmaz, S. Kennedy, S. McGinty, SK Yazdani, SN Iqbal, T Inoue, T Watanabe, U Baber, VY Hoymans, W Khan, W Khan, W Zhu, WC Carlyle, WJ Denny, X Zhu, Y Nakashima, Y Wang, ZA Ali   +80 more
core   +2 more sources

Poly(O‐Propargyl‐N‐Amino Carbamate), a Reactive Polymer to Underpin Biomedical Applications of Poly(acetylene)s

Macromolecular Rapid Communications, EarlyView.
We report here a new methodology to prepare functional poly(acetylene)s under aqueous conditions. This methodology is underpinned by poly(O‐propargyl‐N‐amino carbamate) (P1), a reactive poly(acetylene) carrying acyl hydrazines. Thus, P1 reacts with aldehydes to give functional poly(acetylene)s, including cationic, hydrophobic, and sugar‐loaded poly ...
Tom Leigh, Greta Bellio, Daniel Crisan, Amit Deb, Alba Ramil‐Bouzas, Andrey Romanyuk, Ivan Torreiro‐Leon, Ana Rey‐Rico, Paco Fernandez‐Trillo   +8 more
wiley   +1 more source

Mechanisms of drug solubilization by polar lipids in biorelevant media

European Journal of Pharmaceutical Sciences, 2020
Despite the widespread use of lipid excipients in both academic research and oral formulation development, rational selection guidelines are still missing. In the current study, we aimed to establish a link between the molecular structure of commonly used polar lipids and drug solubilization in biorelevant media.
Vladimir Katev, Zahari Vinarov, Slavka S. Tcholakova   +2 more
openaire   +2 more sources

Site selective reading of epigenetic markers by a dual-mode synthetic receptor array. [PDF]

, 2017
Variably functionalized self-folding deep cavitands form an arrayed, fluorescent indicator displacement assay system for the detection of post-translationally modified (PTM) histone peptides.
Bardeen, Christopher J, Byers, Samantha R, Easley, Connor J, Gill, Adam D, Hooley, Richard J, Liu, Yang, Mettry, Magi, Perez, Lizeth, Zhong, Wenwan   +8 more
core   +2 more sources

Charge Regulation in Crowded Solutions of a Weak Polyelectrolyte: Steric Interactions

Israel Journal of Chemistry, Volume 66, Issue 3, May 2026.
Weak polyelectrolytes (WPE) solvated in biorelevant media and synthetic complex fluids that contain substantial concentrations of macromolecules, molecular assemblies, and nanoparticles are observed to exhibit deviations from the acid–base equilibrium observed in single‐component solutions.
David Attia, Evgenee Yekymov, Rachel Yerushalmi‐Rozen   +2 more
wiley   +1 more source

Strain‐Release Diversification of 1‐Azabicyclobutanes via Bromide/Nickel Relay Catalyzed 1,3‐Bis‐Carbofunctionalization

Angewandte Chemie, Volume 138, Issue 7, 9 February 2026.
A four‐component synthesis of azetidines with an all‐carbon quaternary center via strain‐release 1,3‐bis‐carbofunctionalization of 1‐azabicyclobutanes (ABB) is described. Each reaction component can be modified to permit a high‐throughput‐like library preparation, producing azetidines with various appendages, including biorelevant molecules.
Yi‐Hua Lee, Che‐Ming Hsu, Shinje Miñoza, Ya‐Fang Shih, Yu‐Chun Ding, Tzu‐Yao Hsu, Song‐Ting Chen, Kuei‐Chen Chang, Wen‐Hsuan Lee, Yuya A. Lin, Hsuan‐Hung Liao   +10 more
wiley   +2 more sources

Validación de un método analítico empleando cromatografía líquida de alta eficiencia para la determinación de ibuprofeno en medios biorrelevantes Validation of an analytical method by liquid chromatography for determination of ibuprofen in biorelevant media

Química Nova, 2010
An analytical method by liquid chromatography has been proposed and validated to study the apparent solubility of ibuprofen in biorelevant dissolution media.
Sandra M. Gómez, Jorge A. Martínez, Fleming Martínez   +2 more
doaj   +1 more source

Optically induced electrothermal microfluidic tweezers in bio-relevant media

Scientific Reports, 2023
Non-contact micro-manipulation tools have enabled invasion-free studies of fragile synthetic particles and biological cells. Rapid electrokinetic patterning (REP) traps target particles/cells, suspended in an electrolyte, on an electrode surface.
Kshitiz Gupta, Hye-Ran Moon, Zhengwei Chen, Bumsoo Han, Nicolas G. Green, Steven T. Wereley   +5 more
doaj   +1 more source

Pharmaceutical Science without borders: The 8th APS International PharmSci 2017 [PDF]

, 2017
The Academy of Pharmaceutical Sciences (APSGB) is delighted to partner with the British Journal of Pharmacy to publish key abstracts of posters presented at this year’s APS PharmSci Conference held at the University of Hertfordshire 5th to 7th September ...
Wahlich, John
core   +1 more source