Results 51 to 60 of about 4,221 (165)
Química Nova, 2010 An analytical method by liquid chromatography has been proposed and validated to study the apparent solubility of ibuprofen in biorelevant dissolution media.
Sandra M. Gómez +2 more
doaj +1 more source
British Journal of Pharmacy, 2022 The dynamic colon model isa biorelevant in vitro model of the human proximal colon. In vivo, the large intestine mixes its contents using peristaltic waves that propagate both forwards(antegrade) and backwards (retrograde).
Connor O'Farrell +3 more
doaj +1 more source
Small, Volume 22, Issue 55, 1 October 2026.Poly(N‐acryloyl glycine) hydrogel microparticles were fabricated via droplet‐based microfluidics and in situ photopolymerization. Rheology and MQ‐NMR revealed pronounced effects of pH and Ca2+ on network constraints and chain mobility, governing extensive swelling.
Yusuf Dursun +5 more
wiley +1 more source
PharmaceuticsThe increasing prevalence of esophageal disease highlights the clinical relevance of novel, long-lasting mucoadhesive oral dosage forms. The EsoCap device enables targeted local application of films in the esophagus.
Friederike Brokmann +2 more
doaj +1 more source
Optically induced electrothermal microfluidic tweezers in bio-relevant media
Scientific Reports, 2023 Non-contact micro-manipulation tools have enabled invasion-free studies of fragile synthetic particles and biological cells. Rapid electrokinetic patterning (REP) traps target particles/cells, suspended in an electrolyte, on an electrode surface.
Kshitiz Gupta +5 more
doaj +1 more source
π‐Extended Silyl Enolates as Emerging Platforms in Radical Chemistry
European Journal of Organic Chemistry, Volume 29, Issue 36, 24 September 2026.This review covers the emerging role of π‐extended silyl polyenol ethers in radical chemistry. It highlights their versatile roles as electron‐rich SOMOphiles, silyl radical cation precursors, and nucleophilic partners in radical–polar crossover manifolds, while considering recent advances in photoredox catalysis, electrochemistry, and transition metal‐
Debora Guazzetti +3 more
wiley +1 more source
Expanding the Scope of 1,2‐Diazepines Through Alternative Activation Strategies
European Journal of Organic Chemistry, Volume 29, Issue 35, 19 September 2026.Often overlooked due to tedious synthetic routes, 1,2‐diazepines can be found in handful of biorelevant molecules. Previous reports from our group lifted the principal synthetic lock: a rapid and user‐friendly protocol to reach monocyclic 1,2‐diazepines from readily available pyridines and electrophilic activating groups. Herein, we extend the scope of
Alexis Leblais +4 more
wiley +1 more source
Precision Chemistry for Protein Lysine Modification
Chemistry – A European Journal, Volume 32, Issue 34, 11 September 2026.Selective modification of lysine residues is challenging due to their similar intrinsic reactivity. Inspired by enzymatic recognition, ligand‐guided electrophiles enable site‐selective labeling and functionalization, while ligand‐guided catalyses achieve regioselective installation of bio‐relevant post‐translational modifications.
Mayu Onoda, Motomu Kanai
wiley +1 more source
FEBS Open Bio, Volume 16, Issue 9, Page 1766-1785, September 2026.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Pharmaceutics, 2019 Nifedipine (NIF) is a 1,4-dihydropyridine-based calcium channel blocker with poor solubility, whose bioavailability is highly dependent on the type of formulation.
Athanasios Mantas, Albert Mihranyan
doaj +1 more source