Results 41 to 50 of about 4,221 (165)

Selection of In Vivo Relevant Dissolution Test Parameters for the Development of Cannabidiol Formulations with Enhanced Oral Bioavailability

Pharmaceutics
Background: Cannabidiol (CBD) shows interesting therapeutic properties but has yet to demonstrate its full potential in clinical trials partly due to its low solubility in physiologic media.
Nathan Koch, Quentin Bourcy, Olivier Jennotte, Patrice Chiap, Anna Lechanteur, Jean-Michel Cardot, Brigitte Evrard   +6 more
doaj   +1 more source

Biomorphic navigation system version [PDF]

Известия высших учебных заведений: Прикладная нелинейная динамика
The purpose of this work is to create and study the dynamics of the functioning of a biorelevant visual navigation system. Methods. The work uses simultaneous navigation and mapping systems RatSLAM and Orb-SLAM. The RatSLAM system is a biorelevant model
Malishev, Yuri Александрович, Yakhno, Vladimir Grigorevich   +1 more
doaj   +1 more source

Biorelevant characterization of biopolymers

, 2003
Polymeric biomaterials are synthetically derived or modified biological polymers designed for in vivo use or for use in the proximity of biological fluids.
Ophir, Zohar, Pai, Vaishali, Jaffe, Michael   +2 more
core   +1 more source

Evaluation of fasted and fed simulated intestinal fluid in predicting poorly soluble drugs using 9-point approach

British Journal of Pharmacy, 2023
The extent of absorption of orally administered drugs depends on their solubility in human intestinal fluid (HIF). Simulated intestinal fluid is used as biorelevant media to determine drug solubility in vitro.
Rana Tamimi , Ibrahim Khadra, Hannah Batchelor, Gavin Halbert, Maria Ines Silva   +4 more
doaj   +1 more source

Design and development of a biorelevant simulated human lung fluid [PDF]

, 2018
Biorelevant fluids are required to enable meaningful in vitro experimental determinations of the biopharmaceutical properties of inhaled medicines, e.g. drug solubility, particle dissolution, cellular uptake.
Harvey, Richard D., Royall, Paul G.; id_orcid, Forbes, Ben, Hassoun, Mireille   +3 more
core   +1 more source

Recent Advances in Studying In Vitro Drug Permeation Across Mucosal Membranes

Pharmaceutics
Transmucosal drug products, such as aerosols, films, semisolids, suppositories, and tablets, have been developed for the treatment of various human diseases and conditions. Transmucosal drug absorption is highly influenced by the biological structures of
Juan Song, Zizhao Xu, Lingxiao Xie, Jie Shen   +3 more
doaj   +1 more source

A Novel Class of “Super‐Strained” Spiro Heterocycles: Gateway to 1‐Azaspiro[3.3]heptane Derivatives, and Biological Validation

Angewandte Chemie, Volume 138, Issue 36, 1 September 2026.
A new class of “super‐strained” spiro heterocycles—spirocyclic 1‐azabicyclo[1.1.0]butanes—was synthesized via insertion of cyclobutane‐, oxetane‐, and azetidine‐containing sulfonium reagents into substituted azirines. The stability of this new class of compounds was studied.
Philipp Natho, Annarita Vicenti, Marco Colella, Francesco Pasca, Giuseppe Romanazzi, Mauro Niso, Carmen Abate, Ernesto Mesto, Emanuela Schingaro, Renzo Luisi   +9 more
wiley   +2 more sources

Hydrodynamics and mechanical stresses in pharmacopoeial and noncompendial dissolution testing [PDF]

Farmacja Polska, 2020
The first and an essential step of medication’s path inside the human body is a dissolution of an active pharmaceutical ingridient. A dissolution of oral dosage forms occurs as a result of physicochemical and mechanical stresses which are found in ...
Marcela Wiater, Dagmara Hoc, Jadwiga Paszkowska, Grzegorz Garbacz   +3 more
doaj   +1 more source

Development and Validation of a Robust and Efficient HPLC Method for the Simultaneous Quantification of Levodopa, Carbidopa, Benserazide and Entacapone in Complex Matrices

Journal of Pharmacy & Pharmaceutical Sciences, 2017
Purpose: A variety of fixed-dose combination products is used in the therapy of Parkinson Disease. However, to date a proper analytical method applicable for comparative screening of different antiparkinson products was not available.
Erik Wollmer, Sandra Klein
doaj   +1 more source

Stability of Biorelevant Media Under Various Storage Conditions

, 2022
S.6-18The physical and chemical stability of various biorelevant media (FaSSGF, FaSSIF V1, FaSSIF V2, FaSSIF V3, and FeSSIF) were investigated over periods after preparation of up to 120 h at room temperature (RT) (22 degrees C) and 37 degrees C.
Ashtikar, M., Nagasekar, K., Seybert, A., Dressman, J., Klumpp, L., McCullough, O.   +5 more
core   +1 more source