Results 41 to 50 of about 6,100 (218)

Revisiting the Dissolution of Praziquantel in Biorelevant Media and the Impact of Digestion of Milk on Drug Dissolution

Pharmaceutics, 2022
Praziquantel is a poorly water-soluble drug used to treat parasitic infections. Previous studies have suggested that its rate and extent of dissolution in milk and biorelevant media are slow and limited compared to dissolution in the pharmacopoeial ...
Thomas Eason, Gisela Ramirez, Andrew J. Clulow, Malinda Salim, Ben J. Boyd   +4 more
doaj   +1 more source

A microfluidic chip based model for the study of full thickness human intestinal tissue using dual flow [PDF]

, 2016
© 2016 Author(s). The study of inflammatory bowel disease, including Ulcerative Colitis and Crohn's Disease, has relied largely upon the use of animal or cell culture models; neither of which can represent all aspects of the human pathophysiology ...
A. Dawson, Ananthakrishnan A. N., C. Dyer, Itzkowitz S. H., J. Davies, J. Greenman, J. Macfie, L. Karsai, M. Jacobsen, Ponder A., Rodrigues E., Triantafillidis J. K.   +11 more
core   +1 more source

Photoinduced Selective Construction of Densely Functionalized Spirocyclic Ethers With Carbyne Equivalents

Angewandte Chemie, Volume 138, Issue 18, 27 April 2026.
A reactivity programmed cascade between carbyne equivalents and allylic benzoates was developed that sequentially orchestrates all three reactivity modes of carbyne equivalents, enabling the rapid installation of three σ‐bonds at a single carbon center and providing efficient, scalable access to structurally diverse spirocyclic ethers. ABSTRACT Carbyne
Jianke Su, Chu Wang, Zhongping Cai, Jiale Wu, Xu Yan Chen, Jie Wu   +5 more
wiley   +2 more sources

Tetranuclear coordination assemblies based on half-sandwich ruthenium(II) complexes. Non covalent binding to DNA and cytotoxicity. [PDF]

, 2009
The reaction of [(cymene)RuCl2]2 with K2Hoxonate (H3oxonic = 4,6-dihydroxy-2-carboxy-1,3,5-triazine acid) in methanol leads to the formation of the dinuclear half-sandwich ruthenium(II) complex [(cymene)2Ru2(\u3bc-Hoxonato)Cl2] (1a).
Barea, Elisa, Galindo, Miguel Angel, Galli, Simona, Linares, Fatima, Navarro, Jorge A.R., Romero, M. Angustias   +5 more
core   +1 more source

Pyrene, a Test Case for Deep-Ultraviolet Molecular Photophysics [PDF]

, 2019
We determined the complete relaxation dynamics of pyrene in ethanol from the second bright state, employing experimental and theoretical broadband heterodyne detected transient grating and two-dimensional photon echo (2DPE) spectroscopy, using pulses ...
Garavelli, M., Giussani, A., Miller, R., Mukamel, S., Nenov, A., Picchiotti, A., Prokhorenko, V.   +6 more
core   +2 more sources

Biomorphic navigation system version [PDF]

Известия высших учебных заведений: Прикладная нелинейная динамика
The purpose of this work is to create and study the dynamics of the functioning of a biorelevant visual navigation system. Methods. The work uses simultaneous navigation and mapping systems RatSLAM and Orb-SLAM. The RatSLAM system is a biorelevant model
Malishev, Yuri Александрович, Yakhno, Vladimir Grigorevich   +1 more
doaj   +1 more source

European Paediatric Formulation Initiative (EuPFI)-Formulating Ideas for Better Medicines for Children. [PDF]

, 2017
© American Association of Pharmaceutical Scientists 2016, published by Springer US, available online at doi: https://doi.org/10.1208/s12249-016-0584-1The European Paediatric Formulation Initiative (EuPFI), founded in 2007, aims to promote and facilitate ...
C Tuleu, Catherine Tuleu, F Liu, F Liu, Fang Liu, H Batchelor, H Batchelor, H Wachtel, Hannah Batchelor, HK Batchelor, J Walsh, J Walsh, J Walsh, J Walsh, J Walsh, Jenny Walsh, M Pein, Roy Turner, S Salunke, S Salunke, S Salunke, S Salunke, S Salunke, S Salunke, Smita Salunke, T Nunn, T Sam, TB Ernest, Tzuchi Rob Ju   +28 more
core   +4 more sources

Design and development of a biorelevant simulated human lung fluid [PDF]

Journal of Drug Delivery Science and Technology, 2018
Biorelevant fluids are required to enable meaningful in vitro experimental determinations of the biopharmaceutical properties of inhaled medicines, e.g. drug solubility, particle dissolution, cellular uptake. Our aim was to develop a biorelevant simulated lung fluid (SLF) with a well-defined composition and evidence-based directions for use.
Mireille Hassoun, Paul G. Royall, Mark Parry, Richard D. Harvey, Ben Forbes   +4 more
openaire   +4 more sources

Evaluation of fasted and fed simulated intestinal fluid in predicting poorly soluble drugs using 9-point approach

British Journal of Pharmacy, 2023
The extent of absorption of orally administered drugs depends on their solubility in human intestinal fluid (HIF). Simulated intestinal fluid is used as biorelevant media to determine drug solubility in vitro.
Rana Tamimi , Ibrahim Khadra, Hannah Batchelor, Gavin Halbert, Maria Ines Silva   +4 more
doaj   +1 more source

Biorelevant dissolution testing of St John's wort products

Journal of Pharmacy and Pharmacology, 2002
Abstract In contrast to chemically defined drugs, most herbal medicinal products (HMPs) are poorly characterized in terms of their pharmaceutical properties. In many cases it is assumed that the plant extract as a whole is the active moiety, since it is often difficult to identify the individual components responsible for the ...
Kerstin, Westerhoff, Astrid, Kaunzinger, Mario, Wurglics, Jennifer, Dressman, Manfred, Schubert-Zsilavecz   +4 more
openaire   +2 more sources