Silodosin oral films: Development, physico-mechanical properties and in vitro dissolution studies in simulated saliva [PDF]
, 2019 Sublingual film dosage forms for drugs used for fast symptomatic treatment have promise because they allow a rapid onset of action. The aim of this study was to prepare films of silodosin intended for sublingual administration for the symptomatic ...
Adair +57 more
core +2 more sources
Interstellar Formation of Biorelevant Pyruvic Acid (CH3COCOOH) [PDF]
Chem, 2020 Summary Pyruvic acid represents a key molecule in prebiotic chemistry to form metabolites and amino acids. Without liquid water on the early Earth, endogenous formation of pyruvic acid is unlikely, and an exogenous delivery constitutes an appealing alternative.
N. Fabian Kleimeier +3 more
openaire +1 more source
MPTHub: An Open-Source Software for Characterizing the Transport of Particles in Biorelevant Media
Nanomaterials, 2022 The study of particle transport in different environments plays an essential role in understanding interactions with humans and other living organisms.
Leandro Gabriel +4 more
doaj +1 more source
In vitro dissolution models for the prediction of in vivo performance of an oral mesoporous silica formulation [PDF]
, 2017 Drug release from mesoporous silica systems has been widely investigated in vitro using USP Type II (paddle) dissolution apparatus. However, it is not clear if the observed enhanced in vitro dissolution can forecast drug bioavailability in vivo.
Ahern, Robert J. +7 more
core +1 more source
Superiority of Mesoporous Silica-Based Amorphous Formulations over Spray-Dried Solid Dispersions
Pharmaceutics, 2022 The aim of this study was to compare the performance of two amorphous formulation strategies: mesoporous silica via solvent impregnation, and solid dispersions by spray drying. Poorly soluble fenofibrate was chosen as the model drug compound.
Hongwei Zhang +5 more
doaj +1 more source
In vitro simulation of distribution processes following intramuscular injection
Current Directions in Biomedical Engineering, 2016 There is an urgent need for in vitro dissolution test setups for intramuscularly applied dosage forms. Especially biorelevant methods are needed to predict the in vivo behavior of newly developed dosage forms in a realistic way.
Probst Mareike +3 more
doaj +1 more source
Molecules, 2017 Biorelevant dissolution instruments represent an important tool for pharmaceutical research and development. These instruments are designed to simulate the dissolution of drug formulations in conditions most closely mimicking the gastrointestinal tract ...
Ivan Stupák +4 more
doaj +1 more source
Biopharmaceutical classification of poorly soluble drugs with respect to “enabling formulations” [PDF]
, 2013 The large number of drug candidates with poor dissolution characteristics seen in the past decade, has fostered interest in so-called "enabling formulations", i.e., formulations which shall make such drugs bio-available.
Brandl, Martin +3 more
core +1 more source
Organics, 2021 A convenient synthetic approach to previously unknown NH-iminophosphonates bearing 2-, 3-, and 4-pyridyldifluoromethyl groups at the imine carbon atom was developed.
Oksana M. Shavrina +4 more
doaj +1 more source
Numerical prediction of drug release from polyurethane samples combining kinetic model developed by experimental data [PDF]
E3S Web of Conferences, 2021 With the aim of optimizing Drug Eluting Stents (DES), particular attention has been laid on computational methods of controlling the drug release profile among researchers.
Song Jianfei +5 more
doaj +1 more source