Results 11 to 20 of about 6,100 (218)
Biorelevant dissolution of candesartan cilexetil [PDF]
ADMET and DMPK, 2017 The choice of an appropriate medium for dissolution tests is an essential step during a dosage form development. The adequate design of dissolution testing enables forecasting in vivo behavior of drug formulation.
Lucie Gruberová, Bohumil Kratochvil
doaj +3 more sources
Uracil-Peptide-Pyrene Conjugates as Cu<sup>2+</sup>-Sensitive Probes Targeting DNA, RNA, and Biorelevant Model Membranes. [PDF]
ChembiochemWe introduce uracil–triazole–pyrene peptidomimetics whose tunable peptide linkers precisely control light emission, copper binding, and interactions with DNA and RNA. Fine structural adjustments unlock selective biomolecular recognition and striking metal‐ and membrane‐responsive fluorescence, paving the way for a new generation of multifunctional ...
Pavlović Saftić D +2 more
europepmc +2 more sources
A Reproducible Workflow for Macrophage Membrane Isolation and Nanocore Selection Toward Bioinspired Nanoparticles Targeting Immunologically Cold Tumors. [PDF]
Small MethodsA reproducible workflow is established for isolating macrophage membranes to enable the efficient preparation and characterization of membrane‐coated nanoparticles. By optimizing M2‐like nanovesicle stability and nanocore compatibility, this procedure advances the engineering of macrophage membrane‐coated nanoparticles with improved tumor targeting ...
Peixoto D +6 more
europepmc +2 more sources
Pharmaceuticals, 2022 Herein, a simple and rapid HPLC method for the determination of paracetamol milk-containing biorelevant media is proposed. The separation of the analyte from the milk-containing biorelevant media was accomplished isocratically using a mobile phase ...
Natalia Manousi +4 more
doaj +1 more source
Mucin-Protected Caco-2 Assay to Study Drug Permeation in the Presence of Complex Biorelevant Media
Pharmaceutics, 2022 The poor solubility and permeability of compounds beyond Lipinski’s Rule of Five (bRo5) are major challenges for cell-based permeability assays. Due to their incompatibility with gastrointestinal components in biorelevant media, the exploration of ...
Dong Ye +9 more
doaj +1 more source
Compatibility of Caco-2 cells with Simulated Intestinal Fluid-Predicting Permeability
British Journal of Pharmacy, 2023 The Caco-2 cell model is considered the gold standard when analysing drug permeability and risk-assessing bioavailability. The use of Simulated Intestinal Fluid (SIF) as a tool in the Caco-2 models is beneficial as this generates a more physiologically ...
Erin Seonaid Campbell +5 more
doaj +1 more source
Separations, 2022 The rate at which oral tobacco-derived nicotine (OTDN) and snus pouches release nicotine into saliva is crucial to determine product performance.
Matthias M. Knopp +3 more
doaj +1 more source
Pharmaceutics, 2020 A small-scale biphasic dissolution setup and a small-scale dissolution-permeation (D-P) setup were evaluated for their usefulness in simulating the luminal precipitation of three lipophilic weak bases—dipyridamole, ketoconazole and itraconazole ...
Patrick J. O’Dwyer +3 more
doaj +1 more source
Pharmaceutics, 2022 Modern pharmaceutical technology still seeks new excipients and investigates the further use in already known ones. An example is magnesium aluminometasilicate Neusilin® US2 (NEU), a commonly used inert filler with unique properties that are usable in ...
Tomáš Bílik +8 more
doaj +1 more source
Comparative study of the potential of poly(2-ethyl-2-oxazoline) as carrier in the formulation of amorphous solid dispersions of poorly soluble drugs [PDF]
, 2019 Despite the fact that solid dispersions are gaining momentum, the number of polymers that have been used as a carrier during the past 50 years is rather limited.
Boel, Eline +5 more
core +1 more source