Results 11 to 20 of about 4,221 (165)
Biorelevant dissolution of candesartan cilexetil [PDF]
ADMET and DMPK, 2017 The choice of an appropriate medium for dissolution tests is an essential step during a dosage form development. The adequate design of dissolution testing enables forecasting in vivo behavior of drug formulation.
Lucie Gruberová, Bohumil Kratochvil
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Biorelevant test for supersaturable formulation
Asian Journal of Pharmaceutical Sciences, 2017 Supersaturable formulation can generate supersaturation after dissolution, providing kinetic advantage in vivo. However, the supersaturation may precipitate before being absorbed, which makes it difficult to ensure and predict its in vivo performance ...
Enxian Lu, Shoufeng Li, Zhongqin Wang
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Neurophysiological advantages of biorelevant methodology of teaching academic disciplines
Открытое образование (Москва), 2017 The analysis of technology of teaching a biorelevant lesson showed when using a traditional methodology of teaching (the sinistrocerebral one), there is a contradiction between social and biological aspects of the cerebrum functional system.
Natalia A. Davidovskaya
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SC Powder – domestic powder for the preparation of biorelevant media from the company Scientific Compliance [PDF]
Разработка и регистрация лекарственных средствThe use of biorelevant dissolution media makes it possible to reproduce conditions as in the human gastrointestinal tract. This expands the capabilities of laboratories involved in the analysis of solid dosage forms and allows obtaining physiologically ...
article Editorial
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, 2022 Dissolution is a key step in the uptake of oral drugs. In order to compare the behaviour of the dissolution of two formulations, the dissolution profile test was used. This assay must be discriminative and should mimic in vivo conditions.
Rocha, Helvécio Vinícius Antunes +2 more
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Separations, 2022 The rate at which oral tobacco-derived nicotine (OTDN) and snus pouches release nicotine into saliva is crucial to determine product performance.
Matthias M. Knopp +3 more
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Pharmaceutics, 2020 A small-scale biphasic dissolution setup and a small-scale dissolution-permeation (D-P) setup were evaluated for their usefulness in simulating the luminal precipitation of three lipophilic weak bases—dipyridamole, ketoconazole and itraconazole ...
Patrick J. O’Dwyer +3 more
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Pharmaceutics, 2022 Modern pharmaceutical technology still seeks new excipients and investigates the further use in already known ones. An example is magnesium aluminometasilicate Neusilin® US2 (NEU), a commonly used inert filler with unique properties that are usable in ...
Tomáš Bílik +8 more
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Can biorelevant media be simplified by using SLS and tween 80 to replace bile compounds? [PDF]
, 2013 In the scientific literature, the use of a surfactant is recommended for both designing quality control tests for water insoluble or sparingly water soluble drugs and for predicting the bioavailability of drugs from various types of formulations.
Taupitz, Thomas, Klein, Sandra
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Application of biorelevant saliva-based dissolution for optimisation of orally disintegrating formulations of felodipine [PDF]
, 2019 The oral cavity is of great importance to the performance of orally retained formulations, including: orally disintegrating tablets, taste-masked formulations, and buccal/sublingual delivery systems.
Gershkovich, Pavel +6 more
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