Results 31 to 40 of about 6,100 (218)
Statistical investigation of the full concentration range of fasted and fed simulated intestinal fluid on the equilibrium solubility of oral drugs [PDF]
, 2018 Upon oral administration the solubility of a drug in intestinal fluid is a key property influencing bioavailability. It is also recognised that simple aqueous solubility does not reflect intestinal solubility and to optimise in vitro investigations ...
Dunn, Claire +5 more
core +1 more source
Biorelevant drug release of Metformin dosage forms using complementary in vitro tools [PDF]
, 2017 Drug release from immediate release (IR) and extended release (ER) metformin products was investigated using the Dow Chemical Company’s FloVitroTM biorelevant dissolution instrument.
Box, Karl +2 more
core +1 more source
Instant FaSSIF and FeSSIF—Biorelevance Meets Practicality [PDF]
Dissolution Technologies, 2009 The objective of this study was to prepare an “instant” form of FaSSIF and FeSSIF that could be implemented easily and reproducibly in the laboratory setting. Concentrated solutions containing bile salts and lecithin were freeze-dried and further processed into bulk packs, blisters, or tablets, or sealed in powder form under nitrogen in vials. Physical
Julia Elisabeth Boni +3 more
openaire +1 more source
Dissolution Testing of Single- and Dual-Component Thyroid Hormone Supplements
Separations, 2019 A method for the analysis of thyroid hormones by liquid chromatography-mass spectrometry was used for the dissolution testing of single- and dual-component thyroid hormone supplements via a two-stage biorelevant dissolution procedure.
Samantha L. Bowerbank +2 more
doaj +1 more source
In Vitro–In Vivo Relationship in Mini-Scale—Enabling Formulations of Corallopyronin A
Pharmaceutics, 2022 In vivo studies in mice provide a valuable model to test novel active pharmaceutical ingredients due to their low material need and the fact that mice are frequently used as a species for early efficacy models.
Tim Becker +16 more
doaj +1 more source
Dithioketal Polymers Via Radical Polymerization of γ‐Dithiobutyrolactone
Angewandte Chemie, EarlyView.γ‐Dithiobutyrolactone (DTBL) behaves like a ring‐retaining monomer in radical copolymerization with a series of conjugated monomers like styrene, t‐butyl acrylate and N,N‐dimethylacrylamide. The resulting copolymers contain controlled fractions of dithioketal linkages in their backbone, allowing chemical degradation.
Maksym Odnoroh +5 more
wiley +2 more sources
Pharmaceutics, 2021 A new cocrystal of Norfloxacin, a poorly soluble fluoroquinolone antibiotic, has been synthetized by a solvent-mediated transformation experiment in toluene, using resorcinol as a coformer. The new cocrystal exists in both anhydrous and monohydrate forms
Hanan Fael +4 more
doaj +1 more source
3D printing of medicines: Engineering novel oral devices with unique design and drug release characteristics [PDF]
, 2015 YesThree dimensional printing (3DP) was used to engineer novel oral drug delivery devices, with specialised design configurations loaded with multiple actives, with applications in personalised medicine.
Abdul W. Basit +7 more
core +1 more source
Development of Mucoadhesive Gel Microbicide to Target Mucosal HIV Reservoirs [PDF]
, 2014 The wide use of microbicide is mainly depends on its effectiveness, less frequent application, ready availability and most importantly cost. The aim of this work was to develop affordable microbicide mucoadhesive gel formulation of synthetic anti HIV ...
Shegokar, Ranjita, Singh, Kamalinder K
core +1 more source
Pharmaceutics, 2021 Highly lipophilic antimalarial drugs, artemether and lumefantrine, whilst an effective fixed-dose combination treatment to lower the malarial disease burden, are therapeutically hindered by low aqueous solubility and varied bioavailability.
Christi A. Wilkins +2 more
doaj +1 more source