Results 1 to 10 of about 4,221 (165)

Characterizing the Physicochemical Properties of Two Weakly Basic Drugs and the Precipitates Obtained from Biorelevant Media

Pharmaceutics, 2022
Generally, some weakly basic insoluble drugs will undergo precipitate and redissolution after emptying from the stomach to the small intestinal, resulting in the limited ability to predict the absorption characteristics of compounds in advance ...
Xijing Chen, Dongyang Liu
exaly   +4 more sources

Optimization of Dissolution Compartments in a Biorelevant Dissolution Apparatus Golem v2, Supported by Multivariate Analysis

Molecules, 2017
Biorelevant dissolution instruments represent an important tool for pharmaceutical research and development. These instruments are designed to simulate the dissolution of drug formulations in conditions most closely mimicking the gastrointestinal tract ...
Jakub Vysloužil, Sylvie Pavloková, Jiří Dohnal   +2 more
exaly   +4 more sources

Mucin-Protected Caco-2 Assay to Study Drug Permeation in the Presence of Complex Biorelevant Media

Pharmaceutics, 2022
The poor solubility and permeability of compounds beyond Lipinski’s Rule of Five (bRo5) are major challenges for cell-based permeability assays. Due to their incompatibility with gastrointestinal components in biorelevant media, the exploration of ...
Dong Ye, Álvaro López Mármol, Verena Lenz, Patricia Muschong, Anita Wilhelm-Alkubaisi, Manuel Weinheimer, Mirko Koziolek, Kerstin A. Sauer, Loic Laplanche, Mario Mezler   +9 more
doaj   +2 more sources

Formulation-dependent dissolution and bioaccessibility of curcuminoids and (S)-ar-turmerone from eight commercial turmeric extract- and curcumin-containing dietary supplements [PDF]

Pharmaceutical Biology
Context Curcumin-containing dietary supplements are widely marketed with claims of enhanced bioavailability, despite well-recognized limitations related to poor aqueous solubility, chemical instability, and extensive first-pass metabolism.
Bill J. Gurley, Catherine M. Gurley, Kumar Katrugunta, Bharathi Avula, Ikhlas A. Khan, Amar Chittiboyina, Philip W. Melchert, John S. Markowitz   +7 more
doaj   +2 more sources

Development of an Age-Appropriate Mini Orally Disintegrating Carvedilol Tablet with Paediatric Biopharmaceutical Considerations

Pharmaceutics, 2021
Owing to considerable differences observed in anatomy and physiology between paediatric subsets, it has been well established that children respond to drugs differently compared to adults.
Dilawar Khan, Daniel Kirby, Simon Bryson, Maryam Shah, Afzal Rahman Mohammed   +4 more
doaj   +1 more source

Optimisation of a High-Throughput Model for Mucus Permeation and Nanoparticle Discrimination Using Biosimilar Mucus

Pharmaceutics, 2022
High-throughput permeation models are essential in drug development for timely screening of new drug and formulation candidates. Nevertheless, many current permeability assays fail to account for the presence of the gastrointestinal mucus layer.
Leah Wright, Timothy J. Barnes, Paul Joyce, Clive A. Prestidge   +3 more
doaj   +1 more source

Understanding the Impact of Age-Related Changes in Pediatric GI Solubility by Multivariate Data Analysis

Pharmaceutics, 2022
The aim of this study was to understand drug solubilization as a function of age and identify drugs at risk of altered drug solubility in newborns and young infants in comparison to adults.
Mariana Guimarães, Anil Maharaj, Andrea Edginton, Maria Vertzoni, Nikoletta Fotaki   +4 more
doaj   +1 more source

Solubility of lamotrigine in age-specific biorelevant media that simulated the fasted- and fed-conditions of the gastric and intestinal environments in pediatrics and adults: implications for traditional, re-formulated, modified, and new oral formulations

BMC Biotechnology, 2023
Background Lamotrigine is an effective antiseizure medication that can be used in the management of focal and generalized epilepsies in pediatric patients.
Ramzi Shawahna, Hala Saba’aneh, Amal Daraghmeh, Yara Qassarwi, Valentina Franco, Xavier Declèves   +5 more
doaj   +1 more source

Development and Validation of an HPLC-UV Method for the Dissolution Studies of 3D-Printed Paracetamol Formulations in Milk-Containing Simulated Gastrointestinal Media

Pharmaceuticals, 2022
Herein, a simple and rapid HPLC method for the determination of paracetamol milk-containing biorelevant media is proposed. The separation of the analyte from the milk-containing biorelevant media was accomplished isocratically using a mobile phase ...
Natalia Manousi, Christina Karavasili, Dimitrios G. Fatouros, Paraskevas D. Tzanavaras, Constantinos K. Zacharis   +4 more
doaj   +1 more source

Compatibility of Caco-2 cells with Simulated Intestinal Fluid-Predicting Permeability

British Journal of Pharmacy, 2023
The Caco-2 cell model is considered the gold standard when analysing drug permeability and risk-assessing bioavailability. The use of Simulated Intestinal Fluid (SIF) as a tool in the Caco-2 models is beneficial as this generates a more physiologically ...
Erin Seonaid Campbell, Hannah Batchelor, James Matthew Butler, Ibrahim Khadra, Nena Minstry, Konstantinos Stamatopoulos   +5 more
doaj   +1 more source