Results 1 to 10 of about 6,031 (160)

Formulation-dependent dissolution and bioaccessibility of curcuminoids and (S)-ar-turmerone from eight commercial turmeric extract- and curcumin-containing dietary supplements [PDF]

Pharmaceutical Biology
Context Curcumin-containing dietary supplements are widely marketed with claims of enhanced bioavailability, despite well-recognized limitations related to poor aqueous solubility, chemical instability, and extensive first-pass metabolism.
Bill J. Gurley, Catherine M. Gurley, Kumar Katrugunta, Bharathi Avula, Ikhlas A. Khan, Amar Chittiboyina, Philip W. Melchert, John S. Markowitz   +7 more
doaj   +2 more sources

Selection of In Vivo Relevant Dissolution Test Parameters for the Development of Cannabidiol Formulations with Enhanced Oral Bioavailability [PDF]

Pharmaceutics
Background: Cannabidiol (CBD) shows interesting therapeutic properties but has yet to demonstrate its full potential in clinical trials partly due to its low solubility in physiologic media.
Nathan Koch, Quentin Bourcy, Olivier Jennotte, Patrice Chiap, Anna Lechanteur, Jean-Michel Cardot, Brigitte Evrard   +6 more
doaj   +2 more sources

Recent Advances in Studying In Vitro Drug Permeation Across Mucosal Membranes [PDF]

Pharmaceutics
Transmucosal drug products, such as aerosols, films, semisolids, suppositories, and tablets, have been developed for the treatment of various human diseases and conditions. Transmucosal drug absorption is highly influenced by the biological structures of
Juan Song, Zizhao Xu, Lingxiao Xie, Jie Shen   +3 more
doaj   +2 more sources

Modification of the Biorelevant Release Testing of Esophageal Applied Mucoadhesive Films and Development of Formulation Strategies to Increase the Mucosal Contact Time [PDF]

Pharmaceutics
The increasing prevalence of esophageal disease highlights the clinical relevance of novel, long-lasting mucoadhesive oral dosage forms. The EsoCap device enables targeted local application of films in the esophagus.
Friederike Brokmann, Paul Simonek, Christoph Rosenbaum   +2 more
doaj   +2 more sources

Biorelevant test for supersaturable formulation

Asian Journal of Pharmaceutical Sciences, 2017
Supersaturable formulation can generate supersaturation after dissolution, providing kinetic advantage in vivo. However, the supersaturation may precipitate before being absorbed, which makes it difficult to ensure and predict its in vivo performance ...
Enxian Lu, Shoufeng Li, Zhongqin Wang
doaj   +3 more sources

Development of an Age-Appropriate Mini Orally Disintegrating Carvedilol Tablet with Paediatric Biopharmaceutical Considerations

Pharmaceutics, 2021
Owing to considerable differences observed in anatomy and physiology between paediatric subsets, it has been well established that children respond to drugs differently compared to adults.
Dilawar Khan, Daniel Kirby, Simon Bryson, Maryam Shah, Afzal Rahman Mohammed   +4 more
doaj   +1 more source

Optimisation of a High-Throughput Model for Mucus Permeation and Nanoparticle Discrimination Using Biosimilar Mucus

Pharmaceutics, 2022
High-throughput permeation models are essential in drug development for timely screening of new drug and formulation candidates. Nevertheless, many current permeability assays fail to account for the presence of the gastrointestinal mucus layer.
Leah Wright, Timothy J. Barnes, Paul Joyce, Clive A. Prestidge   +3 more
doaj   +1 more source

Understanding the Impact of Age-Related Changes in Pediatric GI Solubility by Multivariate Data Analysis

Pharmaceutics, 2022
The aim of this study was to understand drug solubilization as a function of age and identify drugs at risk of altered drug solubility in newborns and young infants in comparison to adults.
Mariana Guimarães, Anil Maharaj, Andrea Edginton, Maria Vertzoni, Nikoletta Fotaki   +4 more
doaj   +1 more source

Characterizing the Physicochemical Properties of Two Weakly Basic Drugs and the Precipitates Obtained from Biorelevant Media

Pharmaceutics, 2022
Generally, some weakly basic insoluble drugs will undergo precipitate and redissolution after emptying from the stomach to the small intestinal, resulting in the limited ability to predict the absorption characteristics of compounds in advance ...
Miao Zhang, Bin Wu, Shudong Zhang, Lin Wang, Qin Hu, Dongyang Liu, Xijing Chen   +6 more
doaj   +1 more source

Solubility of lamotrigine in age-specific biorelevant media that simulated the fasted- and fed-conditions of the gastric and intestinal environments in pediatrics and adults: implications for traditional, re-formulated, modified, and new oral formulations

BMC Biotechnology, 2023
Background Lamotrigine is an effective antiseizure medication that can be used in the management of focal and generalized epilepsies in pediatric patients.
Ramzi Shawahna, Hala Saba’aneh, Amal Daraghmeh, Yara Qassarwi, Valentina Franco, Xavier Declèves   +5 more
doaj   +1 more source