Results 71 to 80 of about 4,221 (165)
, 2010 Dissolution tests that can predict the in vivo performance of drug products are usually called biorelevant dissolution tests. Biorelevant dissolution testing can be used to guide formulation development, to identify food effects on the dissolution and ...
Fotaki, N., Vertzoni, M.
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ChemPhotoChem, Volume 10, Issue 8, August 2026.A water‐soluble and ‐stable 2,5‐bis(arylethynyl)rhodacyclopentadiene fluoresces, with no observable phosphorescence. However, competitive ISC to T1 leads to potent 1O2 sensitization. It binds strongly to DNA, RNA, and protein (BSA); efficiently enters living human cells accumulating preferentially in mitochondrial membranes; and is nontoxic even at ...
Shishir Ghosh +14 more
wiley +1 more source
Разработка и регистрация лекарственных средствIntroduction. Venous thromboembolism and atrial fibrillation are significant causes of vascular mortality. Anticoagulant therapy significantly reduces the risk of ischemic stroke, and dabigatran etexilate, a direct thrombin inhibitor, has become firmly ...
D. M. Devyatkina +5 more
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Dissolution Behavior of Flufenamic Acid in Heated Mixtures with Nanocellulose
Molecules, 2020 Flufenamic acid (FFA) is a problem drug that has up to eight different polymorphs and shows poor solubility. Variability in bioavailability has been reported in the past resulting in limited use of FFA in the oral solid dosage form.
Athanasios Mantas, Albert Mihranyan
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Sex‐Related Differences in Physiologically‐Based Biopharmaceutics Modeling
CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 8, August 2026.Sex‐related differences in gastrointestinal tract physiology and their incorporation into three widely used PBPK platforms (PK‐Sim, GastroPlus, Simcyp) were evaluated. A ketoprofen PBPK model was developed and verified in males, then extrapolated to females using default and sex‐specific refined parameters, demonstrating that user‐defined adjustments ...
Marianela Chavarría‐Rojas +4 more
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Biorelevant Drug Solubility Enhancement Modeled by a Linear Solvation Energy Relationship
, 2017 It is for the pharmaceutical sciences of vital importance to understand how drugs are solubilized in biorelevant media. However, the complexity of fasted state simulated intestinal fluid (FaSSIF) has so far hampered adequate solubility modeling.
Kuentz, Martin +3 more
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α-Aminophosphonates: Effective carriers for the membrane transport of biorelevant species [PDF]
, 1999 The novel lipophilic α-aminophosphonates were synthesized by the Kabachnik-Fields reaction. These compounds exhibited remarkable selectivity as carriers for the membrane transport of the biorelevant species such as α-amino and α-hydroxy ...
Stoikov I., Antipin I., Konovalov A.
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The investigation of kinetics dissolution of prolonged indapamide drugs in biorelevant media
Сеченовский вестник, 2013 In the current work there was performed the development of the method of determination dissolution kinetics in biorelevant media of slightly soluble substance, for example indapamide. The method was validated in terms of specificity, linearity, precision,
E. Yu. Sannikova +3 more
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Dissolution properties of co-amorphous drug-amino acid formulations in buffer and biorelevant media
, 2015 Co-amorphous formulations, particularly binary drug-amino acid mixtures, have been shown to provide enhanced dissolution for poorly-soluble drugs and improved physical stability of the amorphous state.
DeClerck, L. +5 more
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MoleculesAiming toward a novel, noninvasive technique, with a real-time potential application in the monitoring of the complexation of steroidal neuromuscular blocker drugs Vecuronium (Vec) and Rocuronium (Roc) with sugammadex (SDX, medication for the reversal of
Adriana Kenđel +2 more
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