Results 91 to 100 of about 4,221 (165)

88th Annual Meeting of the Meteoritical Society 2026: Abstracts

Meteoritics &Planetary Science, Volume 61, Issue S1, Page S48-S551, August 2026.
wiley   +1 more source

Development and Characterization of Optimized Drug-Loaded Niosomes for Delivery of 5-FU and Irinotecan

Pharmaceutics
Background/Objectives: 5-Fluorouracil (5-FU) and Irinotecan (IRT) are two of the most used chemotherapeutic agents in CRC treatment. However, achieving treatment goals has been hampered by poor drug delivery to tumor sites and associated toxicity from ...
Kafilat O. Agbaje, Simeon K. Adesina, Amusa S. Adebayo   +2 more
doaj   +1 more source

DISSOLUTION MEDIA USED IN DEVELOPMENT AND QUALITY CONTROL OF DRUGS

Разработка и регистрация лекарственных средств, 2019
The main dissolution media recommended for the Dissolution test in Russia and abroad are represented in the review. Possible applications of biorelevant media and media with surfactants are also shown.
O. V. Druzhininskaya, I. E. Smekhova
doaj  

Formation of All Three C2H4O Isomers—Ethylene Oxide (c-C2H4O), Acetaldehyde (CH3CHO), and Vinyl Alcohol (CH2CHOH)—in Ethanol-containing Interstellar Analog Ices

The Astrophysical Journal
Oxygen-containing complex organic molecules are key precursors to biorelevant compounds fundamental for the origins of life. However, the untangling of their interstellar formation mechanisms has just scratched the surface, especially for oxygen ...
Jia Wang, Chaojiang Zhang, Joshua H. Marks, Ralf I. Kaiser   +3 more
doaj   +1 more source

Development and evaluation of a biorelevant medium simulating porcine gastrointestinal fluids

, 2020
Simulated human intestinal media, have proved to be a useful biopharmaceutics tool as a dissolution media for predicting in vivo dissolution and pharmacokinetic profile in humans.
Holm, R., Koehl, N.J., Henze, L.J., Vertzoni, M., Jansen, R., Whitfield, P.D., Griffin, B.T.   +6 more
core  

Considerations for the dynamic role of bile acids during oral drug discovery and development. [PDF]

NPJ Drug Discov
Al-Tamimi Z, Hageman MJ.
europepmc   +1 more source

Deoxygenative functionalization of alcohols, ethers, and carbonyl compounds by chromium catalysis. [PDF]

Sci Adv
Chang W, Jiao T, Chen C, Zhou F, Li X, Wang S, Wang J, Zhang J, Liu J, Cao Y, Zeng X, Cong X.   +11 more
europepmc   +1 more source

Determination of the Mesalazine Solubility at Biorelevant Temperature

<p>Physicochemical properties of drug/drug candidates are still key inputs for drug discovery and development studies. The most important physicochemical properties of these substances are lipophilicity, solubility, acid/base character ...
Poturcu, Kader, Guler, Ekin, Rahimpour, Elaheh, Jouyban, Abolghasem   +3 more
core   +1 more source

Improvement of XZP8257 Dissolution Properties Through Amorphous and Mixed-Phase Precipitate Formation in Biorelevant Media. [PDF]

Biopharm Drug Dispos
Zhang M, Zhang S, Wu B, Zhang Z, Hu Q, Wang L, Liu D.   +6 more
europepmc   +1 more source

Nonequilibrium Formation of C₄ Carbonyls in Interstellar Ices Linked to Amino Acids. [PDF]

ACS Cent Sci
Wang Z, Wang J, Shishova AS, Tuchin SO, McAnally M, Turner AM, Jabari N, Kaiser RI.   +7 more
europepmc   +1 more source