Glucosamine HCl-based solid dispersions to enhance the biopharmaceutical properties of acyclovir [PDF]
, 2019 The objective of the work presented here was to assess the feasibility of using glucosamine HCl as a solid-dispersion (SD) carrier to enhance the biopharmaceutical properties of a BCS class III/IV drug, acyclovir (ACV). The solid-dispersions of acyclovir
Bhagat, Snehal B. +6 more
core +1 more source
Magnetic resonance imaging quantification of fasted state colonic liquid pockets in healthy humans [PDF]
, 2017 The rate and extent of drug dissolution and absorption from solid oral dosage forms is highly dependent on the volume of liquid in the gastrointestinal tract (GIT).
Caroline L. Hoad +18 more
core +1 more source
Coherent anti-Stokes Raman Scattering (CARS) Microscopy Visualizes Pharmaceutical Tablets During Dissolution [PDF]
, 2014 Traditional pharmaceutical dissolution tests determine the amount of drug dissolved over time by measuring drug content in the dissolution medium. This method provides little direct information about what is happening on the surface of the dissolving ...
Fussell, A.L. +4 more
core +3 more sources
Statistical investigation of simulated fed intestinal media composition on the equilibrium solubility of oral drugs [PDF]
, 2017 Gastrointestinal fluid is a complex milieu and it is recognised that gut drug solubility is different to that observed in simple aqueous buffers. Simulated gastrointestinal media have been developed covering fasted and fed states to facilitate in vitro ...
Dunn, Claire +4 more
core +1 more source
In situ conjugation of dithiophenol maleimide polymers and oxytocin for stable and reversible polymer–peptide conjugates [PDF]
, 2015 The in situ one-pot synthesis of peptide–polymer bioconjugates is reported. Conjugation occurs efficiently without the need for purification of dithiophenol maleimide functionalized polymer as a disulfide bridging agent for the therapeutic oxytocin ...
Anderson M. E. +58 more
core +2 more sources
The investigation of kinetics dissolution of prolonged indapamide drugs in biorelevant media
Сеченовский вестник, 2013 In the current work there was performed the development of the method of determination dissolution kinetics in biorelevant media of slightly soluble substance, for example indapamide. The method was validated in terms of specificity, linearity, precision,
E. Yu. Sannikova +3 more
doaj
Dissolution rate of ciprofloxacin and its cocrystal with resorcinol
ADMET and DMPK, 2018 The synthesis of cocrystals is presented as an alternative to improve the properties of active pharmaceutical ingredients, especially those related to solubility and dissolution rate.
Clara Ràfols +5 more
doaj +1 more source
Molecular Recognition of Biorelevant Molecules via Hydrogen Bonding.
NIPPON KAGAKU KAISHI, 1991 非極性有機溶媒中での多点水素結合に基づくホストーゲスト相互作用について検討した。用いたホストは2-ヒドロキシ-1-ナフチル基をもつポルフィリン誘導体および四つのアルキリデン基で橋かけした環状テトラキス(レゾルシノール)誘導体であるが,これらはいずれもフェノール性ヒドロキシル基(対)を単位水素結合部位としてもっている。ゲストはアミノ酸,キノン,ジカルボン酸,ジオール,糖,ヌクレオチドなどの生体関連物質である。多点相互作用に組み込まれた「分子内」水素結合は最適ゲストの捕捉に大きな選択性を与えるのみならず,いちじるしい鎖長選択性・立体選択性をもたらす。また,「分子内」水素結合の分子間水素結合に対する優i位性は約1 .5kcal/molである ...
openaire +2 more sources
Antioxidant activity and cytotoxicity of solubilized C60 and its conjugates with butylated hydroxytoluene [PDF]
, 2011 It has been described that fullerenes (C60) present interesting properties with potential application in clinical conditions related to oxidative stress. One of the most prominent features of fullerenes is the ability to quench free radicals.
Caetano, Liliana Aranha +4 more
core
MoleculesAiming toward a novel, noninvasive technique, with a real-time potential application in the monitoring of the complexation of steroidal neuromuscular blocker drugs Vecuronium (Vec) and Rocuronium (Roc) with sugammadex (SDX, medication for the reversal of
Adriana Kenđel +2 more
doaj +1 more source