Results 171 to 180 of about 1,723 (196)

Developing a Biorelevant Dissolution Method for an Extrudable Core System (ECS) Osmotic Tablet

AAPS PharmSciTech, 2021
The objective of this work is to develop a biorelevant dissolution method to support the clinical study for In Vitro In Vivo Correlation (IVIVC) of the first commercially approved single-layer extrudable core system (ECS) osmotic tablet - the 11 mg tofacitinib modified-release tablet.
Raymond, Chen, Andrew, Blanchard, Joseph, Kushner, Brent, Harrington, Jia, Liu, Vincent, DeMatteo   +5 more
openaire   +2 more sources

Precipitation from amorphous solid dispersions in biorelevant dissolution testing: The polymorphism of regorafenib

International Journal of Pharmaceutics, 2021
Amorphous Solid Dispersions (ASDs) are a major drug formulation technique to achieve higher bioavailability for poorly water-soluble active pharmaceutical ingredients. So far, dissolution tailoring and supersaturation enhancement have been studied in detail, whereas less is known about the importance of formed precipitates with amorphous or crystalline
Martin, Müller, Florian, Platten, Martin, Dulle, Björn, Fischer, Werner, Hoheisel, Peter, Serno, Stefan, Egelhaaf, Jörg, Breitkreutz   +7 more
openaire   +2 more sources

Biorelevant and screening dissolution methods for minocycline hydrochloride microspheres intended for periodontal administration

International Journal of Pharmaceutics, 2021
Currently, there is no compendial-level method to assess dissolution of particulate systems administered in the periodontal pocket. This work seeks to develop dissolution methods for extended release poly(lactic-co-glycolic acid) (PLGA) microspheres applied in the periodontal pocket. Arestin®, PLGA microspheres containing minocycline hydrochloride (MIN)
Sravan Kumar Patel, Ashlee C. Greene, Stuti M. Desai, Sam Rothstein, Iman Taj Basha, James Scott MacPherson, Yan Wang, Yuan Zou, Mostafa Shehabeldin, Charles S. Sfeir, Steven R. Little, Lisa C. Rohan   +11 more
openaire   +2 more sources

Use of biorelevant dissolution and PBPK modeling to predict oral drug absorption

European Journal of Pharmaceutics and Biopharmaceutics, 2018
Compromised oral drug absorption, due to poor aqueous solubility, is one of the major challenges faced by the pharmaceutical industry in the drug discovery and development process. Scientific community is striving to develop tools for accurate prediction of the oral absorption profile of drugs.
Navpreet, Kaur, Ajit, Narang, Arvind Kumar, Bansal   +2 more
openaire   +2 more sources

Theoretical Dissolution Model of Poly-Disperse Drug Particles in Biorelevant Media

Journal of Pharmaceutical Sciences, 2008
The purpose of the present study was to construct the theoretical dissolution model of poly-disperse drug particles in biorelevant media containing bile salt/ lecithin aggregates (micelles or vesicles). The effective diffusion coefficient in the biorelevant medium and the particle size distribution of drug particles were simultaneously factored into ...
Arimichi, Okazaki, Takashi, Mano, Kiyohiko, Sugano   +2 more
openaire   +2 more sources

Understanding the Oral Absorption of Irbesartan Using Biorelevant Dissolution Testing and PBPK Modeling

AAPS PharmSciTech, 2020
Poorly soluble weak bases form a significant proportion of the drugs available in the market thereby making it imperative to understand their absorption behavior. This work aims to mechanistically understand the oral absorption behavior for a weakly basic drug, Irbesartan (IRB), by investigating its pH dependent solubility, supersaturation, and ...
Navpreet, Kaur, Poonam Singh, Thakur, Ganesh, Shete, Rahul, Gangwal, Abhay T, Sangamwar, Arvind Kumar, Bansal   +5 more
openaire   +2 more sources

Simulating the Postprandial Stomach: Biorelevant Test Methods for the Estimation of Intragastric Drug Dissolution

Molecular Pharmaceutics, 2013
Intragastric drug release from solid oral dosage forms can be affected by altered physicochemical and mechanical conditions in the upper gastrointestinal (GI) tract. Food effects may lead to changes of one or more pharmacokinetic parameters and, hence, influence drug plasma levels.
Mirko, Koziolek, Grzegorz, Garbacz, Marco, Neumann, Werner, Weitschies   +3 more
openaire   +2 more sources

Effect of Surfactant–Bile Interactions on the Solubility of Hydrophobic Drugs in Biorelevant Dissolution Media

Molecular Pharmaceutics, 2018
Biorelevant dissolution media (BDM) methods are commonly employed to investigate the oral absorption of poorly water-soluble drugs. Despite the significant progress in this area, the effect of commonly employed pharmaceutical excipients, such as surfactants, on the solubility of drugs in BDM has not been characterized in detail.
Zahari Vinarov, Vladimir Katev, Nikola Burdzhiev, Slavka Tcholakova, Nikolai Denkov   +4 more
openaire   +2 more sources

Biorelevant dissolution testing of colon-specific delivery systems activated by colonic microflora

Journal of Controlled Release, 2008
The fermentation of non-starch polysaccharides by colonic microflora is popular as a triggering mechanism to achieve colon-specific drug delivery in that the existence of colonic microflora is independent of gastrointestinal transit time, pH, and disease conditions, and various delivery systems were developed using this strategy.
openaire   +2 more sources

Evaluation of biorelevant dissolution media simulating fasted and fed states

2018
The most important criteria for evaluating in vitro performance and in vivo behavior of drugs is dissolution tests. It is necessary to provide conditions that best mimic the in vivo media in dissolution tests. The most important condition is the dissolution media used.
Yaşin, Diren Sarısaltık, Teksi̇n, Zeynep Şafak   +1 more
openaire   +1 more source