Results 151 to 160 of about 1,723 (196)

Development of a Predictive Flow Through Cell Dissolution Method for Carbamazepine Modified-Release Tablets. [PDF]

CPT Pharmacometrics Syst Pharmacol
Carvajal Barbosa L, Echeverry SM, Aragón DM.   +2 more
europepmc   +1 more source

SCaN: A Screening and Characterization Platform for Nanosuspensions Enables In Vivo Delivery of a Crystalline hRpn13^Pru Degrader. [PDF]

ACS Pharmacol Transl Sci
Brugger-Muli CS, Gaikwad SM, du Bois W, Sabbasani VR, Swenson RE, Heinz WF, Peat TJ, Mock BA, Walters KJ.   +8 more
europepmc   +1 more source

From simulation to application: enhancing preclinical evaluation of dissolvable microarray patches through PBPK modelling. [PDF]

Drug Deliv Transl Res
Railic M, de Witte WEA, Schaller S, Agboola ST, Sartawi Z, Faisal W, Elkhashab M, Crean A, Vucen S.   +8 more
europepmc   +1 more source

Evaluation of Factors Impacting Nicotine Permeation in Oral Nicotine Pouch Products. [PDF]

ACS Omega
Li XS, Sriram A, Zhuang SM, Aldeek F.
europepmc   +1 more source

Validation of Dissolution Testing with Biorelevant Media: An OrBiTo Study

Molecular Pharmaceutics, 2017
Dissolution testing with biorelevant media has become widespread in the pharmaceutical industry as a means of better understanding how drugs and formulations behave in the gastrointestinal tract. Until now, however, there have been few attempts to gauge the reproducibility of results obtained with these methods.
James Mann, Lukas Klumpp, Philippe Berben   +2 more
exaly   +4 more sources

Dissolution Rate and Apparent Solubility of Poorly Soluble Drugs in Biorelevant Dissolution Media

Molecular Pharmaceutics, 2010
A series of poorly soluble BCS class II compounds with "grease ball" characteristics were assessed for solubility and dissolution rate in biorelevant dissolution media (BDM) with the purpose of investigating which molecular structures gain most in solubility when dissolved under physiologically relevant conditions.
Jonas H Fagerberg, Oksana Tsinman, Alex Avdeef   +2 more
exaly   +4 more sources

Biorelevant Dissolution Media

, 2021
Biorelevant dissolution media are aqueous solutions or suspensions whose composition and physicochemical characteristics closely resemble human fluids found along the different portions of the gastrointestinal tract, developed to study the solubility and/or dissolution profile of orally administered drugs in a more physiologically relevant manner.
Ruiz, María Esperanza, Talevi, Alan
openaire   +3 more sources

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Sources of dissolution variability into biorelevant media

International Journal of Pharmaceutics, 2022
Identifying sources of dissolution variation is often challenging. Biorelevant dissolution media are compositionally complex, can require multiple steps to fabricate, and are utilized across differing laboratories. The objective was to determine the contributions of location, operator, media fabrication method, day, and tablet to total dissolution ...
James E Polli
exaly   +3 more sources

A new biorelevant dissolution method for orodispersible films

European Journal of Pharmaceutics and Biopharmaceutics, 2016
Specific knowledge about the dissolution behavior under biorelevant conditions is of high interest for the rational development of orodispersible films (ODFs). As the conditions in the oral cavity strongly differ from those in the gastrointestinal tract and from those performed with the pharmacopoeial test setups, a biorelevant dissolution setup was ...
Jörg Breitkreutz
exaly   +3 more sources