Correlation Between Dissolution Profiles of Salt-Form Drugs in Biorelevant Bicarbonate Buffer and Oral Drug Absorption: Importance of Dose/ Fluid Volume Ratio. [PDF]
Pharm ResTarumi Y, Higashiguchi Y, Sugano K.
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Supramolecular Complexation of Niclosamide and Nafamostat: Improved Physicochemical Profile and Enhanced Anticancer Effect. [PDF]
Pharmaceuticals (Basel)Byeon SE, Baskaran R, Park YJ.
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Integrating In Vitro Dissolution and Physiologically Based Pharmacokinetic Modeling for Generic Drug Development: Evaluation of Amorphous Solid Dispersion Formulations for Tacrolimus. [PDF]
PharmaceuticsKarakitsios E +5 more
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Pre-Formulation Studies of Lipid-Based Formulation Approach for a Poorly Water-Soluble Biopharmaceutics Classification System Class II Model Drug: Bosentan. [PDF]
Turk J Pharm SciYılmaz Usta D, Teksin ZŞ.
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Validation of Dissolution Testing with Biorelevant Media: An OrBiTo Study
Molecular Pharmaceutics, 2017 Dissolution testing with biorelevant media has become widespread in the pharmaceutical industry as a means of better understanding how drugs and formulations behave in the gastrointestinal tract.
Lukas Klumpp +2 more
exaly +2 more sources
Integration of Biorelevant Pediatric Dissolution Methodology into PBPK Modeling to Predict In Vivo Performance and Bioequivalence of Generic Drugs in Pediatric Populations: a Carbamazepine Case Study [PDF]
AAPS Journal, 2023 This study investigated the impact of gastro-intestinal fluid volume and bile salt (BS) concentration on the dissolution of carbamazepine (CBZ) immediate release (IR) 100 mg tablets and to integrate these in vitro biorelevant dissolution profiles into ...
Abdullah Al Shoyaib +2 more
exaly +5 more sources
Real-time dissolution behavior of furosemide in biorelevant media as determined by UV imaging
Pharmaceutical Development and Technology, 2013 The potential of UV imaging as a new small scale flow-through dissolution testing platform and its ability to incorporate biorelevant media was tested. Furosemide was utilized as a model poorly soluble drug, and dissolution media simulating conditions in
Jukka Rantanen +2 more
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International Journal of Pharmaceutics, 2013 Biorelevant dissolution behaviour of the amorphous sodium salt and amorphous acid forms of furosemide was evaluated, together with investigations of the solid state changes during in vitro dissolution in medium simulating the conditions in the small ...
Line Hagner Nielsen +2 more
exaly +2 more sources
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