Results 161 to 170 of about 1,723 (196)

Online monitoring of dissolution tests using dedicated potentiometric sensors in biorelevant media

European Journal of Pharmaceutics and Biopharmaceutics, 2011
The performance of the Ion-Selective Electrode (ISE) for in vitro dissolution testing using biorelevant media was evaluated in this study. In vitro dissolution was carried out using USP apparatus 2 (paddle method) with classical and with updated biorelevant media to simulate the pre- and postprandial states.
Juenemann, Daniel, Bohets, Hugo, Ozdemir, Mahir, de Maesschalck, Roy, Vanhoutte, Koen, Peeters, Karl, Nagels, Luc, Dressman, Jennifer B.   +7 more
openaire   +4 more sources

Integration of Biorelevant Pediatric Dissolution Methodology into PBPK Modeling to Predict In Vivo Performance and Bioequivalence of Generic Drugs in Pediatric Populations: a Carbamazepine Case Study [PDF]

AAPS Journal, 2023
This study investigated the impact of gastro-intestinal fluid volume and bile salt (BS) concentration on the dissolution of carbamazepine (CBZ) immediate release (IR) 100 mg tablets and to integrate these in vitro biorelevant dissolution profiles into ...
Gopal Pawar, Lanyan Fang, Gilbert J Burckart   +2 more
exaly   +2 more sources

Biorelevant characterisation of amorphous furosemide salt exhibits conversion to a furosemide hydrate during dissolution

International Journal of Pharmaceutics, 2013
Biorelevant dissolution behaviour of the amorphous sodium salt and amorphous acid forms of furosemide was evaluated, together with investigations of the solid state changes during in vitro dissolution in medium simulating the conditions in the small ...
Line Hagner Nielsen, Jesper Østergaard, Thomas Rades   +2 more
exaly   +2 more sources

Real-time dissolution behavior of furosemide in biorelevant media as determined by UV imaging

Pharmaceutical Development and Technology, 2013
The potential of UV imaging as a new small scale flow-through dissolution testing platform and its ability to incorporate biorelevant media was tested. Furosemide was utilized as a model poorly soluble drug, and dissolution media simulating conditions in
Kaisa Naelapää, Jukka Rantanen, Anette Müllertz   +2 more
exaly   +2 more sources

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Development and optimisation of simulated salivary fluid for biorelevant oral cavity dissolution

European Journal of Pharmaceutics and Biopharmaceutics, 2021
Drug release within the oral cavity can be of paramount importance for formulations that are designed for specific purposes such as taste-masking, faster onset of therapeutic action, localization of treatment or avoidance of first-pass metabolism.
Joseph, Ali, Jong, Bong Lee, Sally, Gittings, Alessandro, Iachelini, Joanne, Bennett, Anne, Cram, Martin, Garnett, Clive J, Roberts, Pavel, Gershkovich   +8 more
openaire   +2 more sources

Dissolution of solid lipid extrudates in biorelevant media

International Journal of Pharmaceutics, 2012
Solid lipid extrudates with the model drug praziquantel were produced with chemically diverse lipids and investigated regarding their dissolution behaviour in different media. The lipids used in this study were glyceryl tripalmitate, glyceryl dibehenate, glyceryl monostearate, cetyl palmitate and solid paraffin.
R, Witzleb, A, Müllertz, V-R, Kanikanti, H-J, Hamann, P, Kleinebudde   +4 more
openaire   +2 more sources

Application of biorelevant dissolution tests to the prediction of in vivo performance of diclofenac sodium from an oral modified-release pellet dosage form

European Journal of Pharmaceutical Sciences, 2009
In vitro biorelevant dissolution tests enabling the prediction of in vivo performance of an oral modified-release (MR) dosage form were developed in this study.
Ekarat Jantratid, Maria Vertzoni, Jennifer B Dressman   +2 more
exaly   +1 more source

A biorelevant dissolution stress test device – background and experiences

Expert Opinion on Drug Delivery, 2010
The prediction of the in vivo drug release characteristics of modified release (MR) oral dosage forms by in vitro dissolution tests is a prerequisite for successful product development.To improve the predictive power of dissolution testing, the authors recently developed a new dissolution test apparatus that simulates physical conditions of the ...
Grzegorz, Garbacz, Sandra, Klein, Werner, Weitschies   +2 more
openaire   +2 more sources

Biorelevant dissolution media: Aggregation of amphiphiles and solubility of estradiol

Journal of Pharmaceutical Sciences, 2006
Biorelevant dissolution media containing bile salt and lecithin at concentrations appropriate for fed and fasted state are useful when testing oral solid formulations of poorly water-soluble drugs. Dilution of amphiphile solutions affects the aggregation state of the amphiphiles because bile salt is partitioned between the aqueous phase and the ...
Ilardia-Arana, David, Kristensen, Henning G, Müllertz, Anette   +2 more
openaire   +3 more sources

Investigation of monensin Type A medicated article dissolution profiles in biorelevant media

Journal of Veterinary Pharmacology and Therapeutics, 2020
AbstractIn the United States, a generic Type A medicated article (premix) product can gain government approval by demonstrating in vivo bioequivalence (BE) to the pioneer product in a blood level, pharmacodynamic, or clinical BE study. A biowaiver can be granted based on several criteria including solubility or a dose adjusted method.
Beverly J. Krabel, Laura B. Foust, Gary B. Fuller, Andrew J. Foss, Luke H. Garner, Robert P. Hunter   +5 more
openaire   +2 more sources