Results 171 to 180 of about 121,897 (203)
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Lessons from the rifamycin biosynthetic gene cluster
Current Opinion in Chemical Biology, 1999There is currently intense interest in unravelling the modus operandi of type I modular polyketide synthases in order to lay the ground work for their use in the combinatorial biosynthesis of new bioactive molecules. Much of our knowledge is derived from studies on 6-deoxyerythronolide B (DEBS), the enzyme assembling the polyketide backbone of ...
H G, Floss, T W, Yu
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Leveraging yeast to characterize plant biosynthetic gene clusters
Current Opinion in Plant Biology, 2023Plant biosynthetic gene clusters (BGCs) contain multiple physically clustered non-homologous genes that encode enzymes catalyzing diverse reactions in one plant natural product biosynthetic pathway. A growing number of plant BGCs have emerged as an underlying resource for understanding plant specialized metabolism and evolution, but the ...
Yinan Wu, Franklin L. Gong, Sijin Li
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Inducing Global Expression of Actinobacterial Biosynthetic Gene Clusters
2022Bacteria produce an impressive array of bioactive specialized metabolites, with Streptomyces (and the actinobacteria more generally) being unusually diverse and prolific producers. However, the biosynthetic potential of these organisms has yet to be fully explored, as many of the biosynthetic gene clusters that direct the synthesis of these natural ...
Meghan A, Pepler +3 more
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Characterization of the Actinonin Biosynthetic Gene Cluster
ChemBioChem, 2018AbstractThe hydroxamate moiety of the natural product actinonin mediates inhibition of metalloproteinases because of its chelating properties towards divalent cations in the active site of those enzymes. Owing to its antimicrobial activity, actinonin has served as a lead compound for the development of new antibiotic drug candidates.
Felix Wolf +5 more
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Nat. Prod. Rep., 2011
Ergot alkaloids are toxins and important pharmaceuticals which are produced biotechnologically on an industrial scale. They have been identified in two orders of fungi and three families of higher plants. The most important producers are fungi of the genera Claviceps, Penicillium and Aspergillus (all belonging to the Ascomycota).
Christiane, Wallwey, Shu-Ming, Li
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Ergot alkaloids are toxins and important pharmaceuticals which are produced biotechnologically on an industrial scale. They have been identified in two orders of fungi and three families of higher plants. The most important producers are fungi of the genera Claviceps, Penicillium and Aspergillus (all belonging to the Ascomycota).
Christiane, Wallwey, Shu-Ming, Li
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Why biosynthetic genes for chemical defense compounds cluster
Trends in Plant Science, 2012In plants, the genomic clustering of non-homologous genes for the biosynthesis of chemical defense compounds is an emerging theme. Gene clustering is also observed for polymorphic sexual traits under balancing selection, and examples in plants are self-incompatibility and floral dimorphy.
Takos, Adam Matthew, Rook, Frederik
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Biosynthetic gene clusters for epipolythiodioxopiperazines in filamentous fungi
Mycological Research, 2008Epipolythiodioxopiperazines (ETPs) are toxic secondary metabolites made only by fungi. Recent research efforts have provided insight into the molecular mechanisms of the toxicity of these compounds. The availability of complete genome sequences for many fungi has also facilitated the identification of putative ETP biosynthetic gene clusters. Expression
Ellen M, Fox, Barbara J, Howlett
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Biosynthetic Gene Clusters in Bacteria: A Review
Proceedings of the Pakistan Academy of Sciences: B. Life and Environmental Sciences, 2022Soil is a nutrient-rich environment that harbors billions of microbial species. The diversity of microbes in an environment varies with the change in edaphic factors. To survive these environmental changes, microbes produce secondary metabolites which are not directly associated with their growth and reproduction. Bacterial genomes possess biosynthetic
Rimsha Dilshad, Nazia Jamil, Rida Batool
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A Bioinformatics Workflow for Investigating Fungal Biosynthetic Gene Clusters
2022Predicting secondary metabolite biosynthetic gene clusters is a routine analysis performed for each newly sequenced fungal genome. Yet, the usefulness of such predictions remains restricted as they provide total numbers of biosynthetic pathways with only very limited biological significance.
Collemare, J., Navarro-Munoz, J.C.
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A gene cluster of the ochratoxin A biosynthetic genes inPenicillium
Mycotoxin Research, 2006A putative ochratoxin A (OTA) biosynthetic gene cluster inP. nordicum has been identified. The first part of the gene cluster is located on a DNA fragment of 10 kb in length and harbours three genes. A gene with high homology to an alkaline serine protease gene (accession number AY557343), which represents the upstream border of the cluster ...
R, Geisen +2 more
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