Results 81 to 90 of about 373,234 (333)

The evolutionary life cycle of the polysaccharide biosynthetic gene cluster based on the Sphingomonadaceae

Scientific Reports, 2017
Although clustering of genes from the same metabolic pathway is a widespread phenomenon, the evolution of the polysaccharide biosynthetic gene cluster remains poorly understood.
Mengmeng Wu, Haidong Huang, Guoqiang Li, Yi Ren, Zhong-Wen Shi, Xiaoyan Li, Xiaohui Dai, Ge Gao, Mengnan Ren, Tingting Ma   +9 more
semanticscholar   +1 more source

Efficient exploration of terpenoid biosynthetic gene clusters in filamentous fungi

Nature Catalysis, 2022
Terpenoids, critical components of human medicine, are the largest family of natural products. Fungi are an important source of terpenoids, but many of the corresponding biosynthetic gene clusters (BGCs) are silent in laboratory conditions.
Yujie Yuan, Shu Cheng, Guangkai Bian, Pan Yan, Zhengning Ma, Wen Dai, Rong Chen, Shuai Fu, Huiwen Huang, Haoming Chi, Yousheng Cai, Zixin Deng, Tiangang Liu   +12 more
semanticscholar   +1 more source

Elucidation of novel turnagainolides and their biosynthetic gene cluster in <i>Bacillus subtilis</i>. [PDF]

Appl Environ Microbiol
Turnagainolides represent a unique class of cyclic depsipeptides characterized by the presence of a rare (E)-3-hydroxy-5-phenylpent-4-enoic acid (Hppa) residue, exhibiting diverse bioactivities.
Li P, Han S, Wang M, Zhang X, Zhi S, Jin M, Jokela J, He S, Liu L.   +8 more
europepmc   +2 more sources

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Microfluidic automated plasmid library enrichment for biosynthetic gene cluster discovery [PDF]

, 2020
Microbial biosynthetic gene clusters are a valuable source of bioactive molecules. However, because they typically represent a small fraction of genomic material in most metagenomic samples, it remains challenging to deeply sequence them.
Xu, Peng, Sun, Chen, Modavi, Cyrus, Demaree, Benjamin, Liang, Benjamin, Twigg, Frederick, Zhang, Wenjun, Abate, Adam R   +7 more
core   +1 more source

Characterization of the biosynthetic gene cluster for cryptic phthoxazolin A in Streptomyces avermitilis. [PDF]

PLoS ONE, 2018
Phthoxazolin A, an oxazole-containing polyketide, has a broad spectrum of anti-oomycete activity and herbicidal activity. We recently identified phthoxazolin A as a cryptic metabolite of Streptomyces avermitilis that produces the important anthelmintic ...
Dian Anggraini Suroto, Shigeru Kitani, Masayoshi Arai, Haruo Ikeda, Takuya Nihira   +4 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

A single Streptomyces symbiont makes multiple antifungals to support the fungus farming ant Acromyrmex octospinosus

, 2013
Attine ants are dependent on a cultivated fungus for food and use antibiotics produced by symbiotic Actinobacteria as weedkillers in their fungus gardens. Actinobacterial species belonging to the genera Pseudonocardia, Streptomyces and Amycolatopsis have
Brearley, Charles, Seipke, Ryan F., Barke, Joerg, Yu, Douglas W., Goss, Rebecca J. M., Hill, Lionel, Hutchings, Matthew I.   +6 more
core   +1 more source

Transcriptional Activation of Biosynthetic Gene Clusters in Filamentous Fungi

Frontiers in Bioengineering and Biotechnology, 2022
Filamentous fungi are highly productive cell factories, many of which are industrial producers of enzymes, organic acids, and secondary metabolites. The increasing number of sequenced fungal genomes revealed a vast and unexplored biosynthetic potential ...
László Mózsik, R. Iacovelli, R. Bovenberg, A. Driessen   +3 more
semanticscholar   +1 more source

The Transcriptional Architecture of Bacterial Biosynthetic Gene Clusters

Journal of Natural Products
Abstract Bacteria produce diverse bioactive metabolites with ecological and pharmaceutical importance. These compounds are synthesized by biosynthetic gene clusters (BGCs), whose expression is tightly regulated. While many studies have examined the factors influencing BGC expression, including transcription factors (TFs) and ...
Ribeiro Monteiro, Silvia, Kerdel, Yasmine, Gathot, Julianne, Rigali, Sébastien   +3 more
openaire   +3 more sources