Results 81 to 90 of about 3,674,475 (302)

Efomycins K and L From a Termite-Associated Streptomyces sp. M56 and Their Putative Biosynthetic Origin

Frontiers in Microbiology, 2019
Two new elaiophylin derivatives, efomycins K (1) and L (2), and five known elaiophylin derivatives (3–7) were isolated from the termite-associated Streptomyces sp. M56. The structures were determined by 1D and 2D NMR and HR-ESIMS analyses and comparative
Jonathan L. Klassen, Seoung Rak Lee, Michael Poulsen, Christine Beemelmanns, Ki Hyun Kim   +4 more
doaj   +1 more source

Protocols for yTREX/Tn5‐based gene cluster expression in Pseudomonas putida

Microbial Biotechnology, 2020
Summary Bacterial gene clusters, which represent a genetic treasure trove for secondary metabolite pathways, often need to be activated in a heterologous host to access the valuable biosynthetic products.
Robin Weihmann, Andreas Domröse, Thomas Drepper, Karl‐Erich Jaeger, Anita Loeschcke   +4 more
doaj   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Genes in the putative biosynthetic gene cluster for JBIR-46, -47, and -48.

, 2014
Genes in the putative biosynthetic gene cluster for JBIR-46, -47, and -48.
Jörn Kalinowski (23807), Harald Gross (571760), Judith S. Bauer (571759), Kazuo Shin-ya (133016), Philipp Zeyhle (571758), Lutz Heide (194238)   +5 more
core   +1 more source

Biosynthetic Gene Cluster for the Polyenoyltetramic Acid α-Lipomycin [PDF]

Antimicrobial Agents and Chemotherapy, 2006
ABSTRACT The gram-positive bacterium Streptomyces aureofaciens Tü117 produces the acyclic polyene antibiotic α-lipomycin. The entire biosynthetic gene cluster ( lip gene cluster) was cloned and characterized.
Bihlmaier, C., Welle, E., Hofmann, C., Welzel, K., Vente, A., Breitling, E., Müller, M., Glaser, S., Bechthold, A.   +8 more
openaire   +3 more sources

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Whole-genome analysis and biosynthetic gene cluster profiling of Stenotrophomonas sp. ASucR1 isolated from Sof Umer Cave, Ethiopia

Electronic Journal of Biotechnology
Background: Sof Umer Cave is a unique habitat that hosts industrially significant microbes. In this study, Stenotrophomonas sp. ASucR1 was isolated from the cave rock and screened for antimicrobial activity.
Abu Feyisa Meka, Gessesse Kebede Bekele, Selfu Girma Gebre, Musin Kelel Abas, Mesfin Tafesse Gemeda   +4 more
doaj   +1 more source

Identification and engineering of 32 membered antifungal macrolactone notonesomycins

Microbial Cell Factories, 2020
Notonesomycin A is a 32-membered bioactive glycosylated macrolactone known to be produced by Streptomyces aminophilus subsp. notonesogenes 647-AV1 and S. aminophilus DSM 40186.
Falicia Goh, Mingzi M. Zhang, Tian Ru Lim, Kia Ngee Low, Choy Eng Nge, Elena Heng, Wan Lin Yeo, Fernanda L. Sirota, Sharon Crasta, Zann Tan, Veronica Ng, Chung Yan Leong, Huibin Zhang, Alexander Lezhava, Swaine L. Chen, Shawn S. Hoon, Frank Eisenhaber, Birgit Eisenhaber, Yoganathan Kanagasundaram, Fong T. Wong, Siew Bee Ng   +20 more
doaj   +1 more source

Proposed functions of open reading frames in the zeamine biosynthetic gene cluster region.

, 2013
Proposed functions of open reading frames in the zeamine biosynthetic gene cluster region.
Jef Rozenski (57476), Abram Aertsen (43457), Chris Lamberigts (102431), Piet Herdewijn (8001), Chris Michiels (102452), Birgit Uytterhoeven (102426), Rob Van Houdt (102422), Eveline Lescrinier (7999), Wesley Mattheus (102410), Ling-Jie Gao (102414), Pieter Moons (102418), Rob Lavigne (102459), Joleen Masschelein (102407)   +12 more
core   +1 more source

Discovery of the lomaiviticin biosynthetic gene cluster in Salinispora pacifica [PDF]

Tetrahedron, 2014
The lomaiviticins are a family of cytotoxic marine natural products that have captured the attention of both synthetic and biological chemists due to their intricate molecular scaffolds and potent biological activities. Here we describe the identification of the gene cluster responsible for lomaiviticin biosynthesis in Salinispora pacifica strains DPJ ...
Jeffrey E, Janso, Brad A, Haltli, Alessandra S, Eustáquio, Kerry, Kulowski, Abraham J, Waldman, Li, Zha, Hitomi, Nakamura, Valerie S, Bernan, Haiyin, He, Guy T, Carter, Frank E, Koehn, Emily P, Balskus   +11 more
openaire   +2 more sources