Results 71 to 80 of about 373,234 (333)
Heterologous Expression of Novobiocin and Clorobiocin Biosynthetic Gene Clusters [PDF]
Applied and Environmental Microbiology, 2005 ABSTRACT A method was developed for the heterologous expression of biosynthetic gene clusters in different Streptomyces strains and for the modification of these clusters by single or multiple gene replacements or gene deletions with unprecedented speed and versatility.
Alessandra S, Eustáquio +5 more
openaire +2 more sources
Agronomy, 2023 Terpenes and terpenoids contribute aroma and flavor that influence consumer preferences in selecting plant-based products. Computational identification of biosynthetic gene clusters (BGCs) in plants can pave the way for future biosynthetic genetic ...
Roel C. Rabara +2 more
doaj +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Standards in Genomic Sciences, 2018 Microorganisms utilize complex enzymatic pathways to biosynthesize structurally complex and pharmacologically relevant molecules. These pathways are encoded by gene clusters and are found in a diverse set of organisms.
Samuel C. Epstein +2 more
semanticscholar +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Kanamycin biosynthetic gene cluster and proposed kanamycin biosynthetic pathways.
, 2018 (a) Kanamycin biosynthetic gene cluster. (b) Proposed parallel and linear kanamycin biosynthetic pathways.
Zheng Wu (344022) +4 more
core +1 more source
Plant biosynthetic gene clusters in the context of metabolic evolution
Natural product reports (Print), 2022 Covering: up to 2022 Plants produce a wide range of structurally and biosynthetically diverse natural products to interact with their environment. These specialised metabolites typically evolve in limited taxonomic groups presumably in response to ...
S. J. Smit, Benjamin R. Lichman
semanticscholar +1 more source
DoBISCUIT: a database of secondary metabolite biosynthetic gene clusters [PDF]
Nucleic Acids Research, 2012 This article introduces DoBISCUIT (Database of BIoSynthesis clusters CUrated and InTegrated, http://www.bio.nite.go.jp/pks/), a literature-based, manually curated database of gene clusters for secondary metabolite biosynthesis. Bacterial secondary metabolites often show pharmacologically important activities and can serve as lead compounds and/or ...
Natsuko Ichikawa +6 more
openaire +2 more sources
Microbial Cell Factories, 2017 Background Nocamycins I and II, produced by the rare actinomycete Saccharothrix syringae, belong to the tetramic acid family natural products. Nocamycins show potent antimicrobial activity and they hold great potential for antibacterial agent design ...
Xuhua Mo +5 more
doaj +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source