Results 61 to 70 of about 3,454,458 (298)

Genetic and functional characterization of the gene cluster directing the biosynthesis of putisolvin I and II in Pseudomonas putida strain PCL1445 [PDF]

, 2008
Pseudomonas putida PCL1445 secretes two cyclic lipopeptides, putisolvin I and putisolvin II, which possess a surface-tension-reducing ability, and are able to inhibit biofilm formation and to break down biofilms of Pseudomonas species including ...
Dubern, J.F., Stiekema, W.J., Coppoolse, E.R., Bloemberg, G.V.   +3 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Identification of nocamycin biosynthetic gene cluster from Saccharothrix syringae NRRL B-16468 and generation of new nocamycin derivatives by manipulating gene cluster

Microbial Cell Factories, 2017
Background Nocamycins I and II, produced by the rare actinomycete Saccharothrix syringae, belong to the tetramic acid family natural products. Nocamycins show potent antimicrobial activity and they hold great potential for antibacterial agent design ...
Xuhua Mo, Chunrong Shi, Chun Gui, Yanjiao Zhang, Jianhua Ju, Qingji Wang   +5 more
doaj   +1 more source

Identification of Terpene-Related Biosynthetic Gene Clusters in Tobacco through Computational-Based Genomic, Transcriptomic, and Metabolic Analyses

Agronomy, 2023
Terpenes and terpenoids contribute aroma and flavor that influence consumer preferences in selecting plant-based products. Computational identification of biosynthetic gene clusters (BGCs) in plants can pave the way for future biosynthetic genetic ...
Roel C. Rabara, Chengalrayan Kudithipudi, Michael P. Timko   +2 more
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Identification, cloning and heterologous expression of biosynthetic gene cluster for desertomycin [PDF]

, 2020
From our in-house microbial genome database of secondary metabolite producers, we identified a candidate biosynthetic gene cluster for desertomycin from Streptomyces nobilis JCM4274.
Junko Hashimoto, Noriyuki Satoh, Takuya Hashimoto, Hashimoto, Takuya, Suenaga, Hikaru, Fujie, Manabu, Satoh, Noriyuki, Ikeda, Haruo, Hashimoto, Junko, Kazuo Shin-ya, Kozone, Ikuko, Manabu Fujie, Shin-ya, Kazuo, Ikuko Kozone, Haruo Ikeda, Hikaru Suenaga   +15 more
core   +2 more sources

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Characterization of the biosynthetic gene cluster for cryptic phthoxazolin A in Streptomyces avermitilis. [PDF]

PLoS ONE, 2018
Phthoxazolin A, an oxazole-containing polyketide, has a broad spectrum of anti-oomycete activity and herbicidal activity. We recently identified phthoxazolin A as a cryptic metabolite of Streptomyces avermitilis that produces the important anthelmintic ...
Dian Anggraini Suroto, Shigeru Kitani, Masayoshi Arai, Haruo Ikeda, Takuya Nihira   +4 more
doaj   +1 more source

Identification of the Scopularide Biosynthetic Gene Cluster in Scopulariopsis brevicaulis [PDF]

Marine Drugs, 2015
Scopularide A is a promising potent anticancer lipopeptide isolated from a marine derived Scopulariopsis brevicaulis strain. The compound consists of a reduced carbon chain (3-hydroxy-methyldecanoyl) attached to five amino acids (glycine, l-valine, d-leucine, l-alanine, and l-phenylalanine). Using the newly sequenced S. brevicaulis genome we were able
Lukassen, Mie Bech, Saei, Wagma, Sondergaard, Teis Esben, Tamminen, Anu, Kumar, Abhishek, Kempken, Frank, Wiebe, Marilyn G., Sørensen, Jens Laurids   +8 more
openaire   +4 more sources

Kanamycin biosynthetic gene cluster and proposed kanamycin biosynthetic pathways.

, 2018
(a) Kanamycin biosynthetic gene cluster. (b) Proposed parallel and linear kanamycin biosynthetic pathways.
Zheng Wu (344022), Huanzhang Xia (561060), Xianpu Ni (3491882), Junyang Sun (4285090), Wenli Gao (245749)   +4 more
core   +1 more source