Results 41 to 50 of about 373,234 (333)

Mining microbial genomes for new natural products and biosynthetic pathways [PDF]

, 2008
Analyses of microbial genome sequences have revealed numerous examples of ‘cryptic’ or ‘orphan’ biosynthetic gene clusters, with the potential to direct the production of novel, structurally complex natural products.
G. L. Challis, Challis, Gregory L.
core   +1 more source

Heterologous expression of the diazaquinomycin biosynthetic gene cluster [PDF]

Journal of Industrial Microbiology and Biotechnology, 2019
Abstract Members of the diazaquinomycin class of natural products have shown potent and selective activity against Mycobacterium tuberculosis. However, poor aqueous solubility has prevented extensive studies in animal models thus far. Our long-term goal is to harness knowledge regarding diazaquinomycin biosynthesis towards the generation
Jana, Braesel, Tuan Anh, Tran, Alessandra S, Eustáquio   +2 more
openaire   +2 more sources

Activation of an unconventional meroterpenoid gene cluster in Neosartorya glabra leads to the production of new berkeleyacetals

Acta Pharmaceutica Sinica B, 2018
Fungal genomes carry many gene clusters seemingly capable of natural products biosynthesis, yet most clusters remain cryptic or down-regulated. Genome mining revealed an unconventional paraherquonin-like meroterpenoid biosynthetic gene cluster in the ...
Tao Zhang, Jun Wan, Zhajun Zhan, Jian Bai, Bingyu Liu, Youcai Hu   +5 more
doaj   +1 more source

One Pathway, Two Cyclic Non-Ribosomal Pentapeptides: Heterologous Expression of BE-18257 Antibiotics and Pentaminomycins from Streptomyces cacaoi CA-170360

Microorganisms, 2021
The strain Streptomyces cacaoi CA-170360 produces the cyclic pentapeptides pentaminomycins A–H and BE-18257 A–C, two families of cyclopeptides synthesized by two non-ribosomal peptide synthetases encoded in tandem within the same biosynthetic gene ...
Fernando Román-Hurtado, Marina Sánchez-Hidalgo, Jesús Martín, Francisco Javier Ortiz-López, Daniel Carretero-Molina, Fernando Reyes, Olga Genilloud   +6 more
doaj   +1 more source

Identification and analysis of the resorcinomycin biosynthetic gene cluster [PDF]

Bioscience, Biotechnology, and Biochemistry, 2015
Abstract Resorcinomycin (1) is composed of a nonproteinogenic amino acid, (S)-2-(3,5-dihydroxy-4-isopropylphenyl)-2-guanidinoacetic acid (2), and glycine. A biosynthetic gene cluster was identified in a genome database of Streptoverticillium roseoverticillatum by searching for orthologs of the genes responsible for biosynthesis of ...
Koichi, Ooya, Yasushi, Ogasawara, Motoyoshi, Noike, Tohru, Dairi   +3 more
openaire   +2 more sources

Expanding our understanding of sequence-function relationships of type II polyketide biosynthetic gene clusters: bioinformatics-guided identification of Frankiamicin A from Frankia sp. EAN1pec. [PDF]

PLoS ONE, 2015
A large and rapidly increasing number of unstudied "orphan" natural product biosynthetic gene clusters are being uncovered in sequenced microbial genomes.
Yasushi Ogasawara, Benjamin J Yackley, Jacob A Greenberg, Snezna Rogelj, Charles E Melançon   +4 more
doaj   +1 more source

Evolution and Diversity of Biosynthetic Gene Clusters in Fusarium

Frontiers in Microbiology, 2018
Plant pathogenic fungi in the Fusarium genus cause severe damage to crops, resulting in great financial losses and health hazards. Specialized metabolites synthesized by these fungi are known to play key roles in the infection process, and to provide survival advantages inside and outside the host.
Koen Hoogendoorn, Koen Hoogendoorn, Lena Barra, Cees Waalwijk, Jeroen S. Dickschat, Theo A. J. van der Lee, Marnix H. Medema   +6 more
openaire   +4 more sources

The erythromycin biosynthetic gene cluster of Aeromicrobium erythreum

Journal of Industrial Microbiology & Biotechnology, 2004
The erythromycin-biosynthetic (ery) gene cluster of Aeromicrobium erythreum was cloned and characterized. The 55.4-kb cluster contains 25 ery genes. Homologues were found for each gene in the previously characterized ery gene cluster from Saccharopolyspora erythraea. In addition, four new predicted ery genes were identified.
Igor A, Brikun, Andrew R, Reeves, William H, Cernota, Minh B, Luu, J Mark, Weber   +4 more
openaire   +2 more sources

Реконструкція філогенії кластерів генів біосинтезу глікопептидів

Фактори експериментальної еволюції організмів, 2017
Aim. In current study we have endeavored to analyze the phylogeny of 18 sequenced glycopeptide biosynthetic gene clusters. Methods. Standard methods of phylogenetic reconstruction were used in this research. Results. We have created sets of conservative
O. S. Yushchuk, B. O. Ostash, L. O. Horbal, V. O. Fedorenko   +3 more
doaj   +1 more source

A deep learning genome-mining strategy for biosynthetic gene cluster prediction

Nucleic Acids Research, 2019
Natural products represent a rich reservoir of small molecule drug candidates utilized as antimicrobial drugs, anticancer therapies, and immunomodulatory agents. These molecules are microbial secondary metabolites synthesized by co-localized genes termed
G. Hannigan, David Prihoda, A. Palicka, Jindrich Soukup, O. Klempíř, Lena Rampula, Jindřich Durčák, M. Wurst, J. Kotowski, Dan Chang, Rurun Wang, Grazia Piizzi, Gergely Temesi, D. Hazuda, C. Woelk, Danny A. Bitton   +15 more
semanticscholar   +1 more source