Results 41 to 50 of about 3,454,458 (298)

The biosynthetic pathway to tetromadurin (SF2487/A80577), a polyether tetronate antibiotic

PLoS ONE, 2020
The type I polyketide SF2487/A80577 (herein referred to as tetromadurin) is a polyether tetronate ionophore antibiotic produced by the terrestrial Gram-positive bacterium Actinomadura verrucosospora.
Rory F. Little, Markiyan Samborskyy, Peter F. Leadlay, Patrick C. Cirino   +3 more
doaj   +2 more sources

Cyclofaulknamycin with the Rare Amino Acid D-capreomycidine Isolated from a Well-Characterized Streptomyces albus Strain

Microorganisms, 2021
Targeted genome mining is an efficient method of biosynthetic gene cluster prioritization within constantly growing genome databases. Using two capreomycidine biosynthesis genes, alpha-ketoglutarate-dependent arginine beta-hydroxylase and pyridoxal ...
Liliya Horbal, Marc Stierhof, Anja Palusczak, Nikolas Eckert, Josef Zapp, Andriy Luzhetskyy   +5 more
doaj   +1 more source

Heterologous expression of the diazaquinomycin biosynthetic gene cluster [PDF]

Journal of Industrial Microbiology and Biotechnology, 2019
Abstract Members of the diazaquinomycin class of natural products have shown potent and selective activity against Mycobacterium tuberculosis. However, poor aqueous solubility has prevented extensive studies in animal models thus far. Our long-term goal is to harness knowledge regarding diazaquinomycin biosynthesis towards the generation
Jana, Braesel, Tuan Anh, Tran, Alessandra S, Eustáquio   +2 more
openaire   +2 more sources

Identification and analysis of the resorcinomycin biosynthetic gene cluster [PDF]

Bioscience, Biotechnology, and Biochemistry, 2015
Abstract Resorcinomycin (1) is composed of a nonproteinogenic amino acid, (S)-2-(3,5-dihydroxy-4-isopropylphenyl)-2-guanidinoacetic acid (2), and glycine. A biosynthetic gene cluster was identified in a genome database of Streptoverticillium roseoverticillatum by searching for orthologs of the genes responsible for biosynthesis of ...
Koichi, Ooya, Yasushi, Ogasawara, Motoyoshi, Noike, Tohru, Dairi   +3 more
openaire   +2 more sources

Characterization of the depsidone gene cluster reveals etherification, decarboxylation and multiple halogenations as tailoring steps in depsidone assembly

Acta Pharmaceutica Sinica B, 2023
Depsides and depsidones have attracted attention for biosynthetic studies due to their broad biological activities and structural diversity. Previous structure‒activity relationships indicated that triple halogenated depsidones display the best anti ...
Jiafan Yang, Zhenbin Zhou, Yingying Chen, Yongxiang Song, Jianhua Ju   +4 more
doaj   +1 more source

Minimum Information about a Biosynthetic Gene cluster [PDF]

, 2017
A wide variety of enzymatic pathways that produce specialized metabolites in bacteria, fungi and plants are known to be encoded in biosynthetic gene clusters.
Geiger, Christoph, Yim, Grace, Düsterhus, Stephanie, Payne, Shelley M, Ploux, Olivier, Viaud, Muriel, Scott, Barry, Petras, Daniel, Kormanec, Jan, Osburne, Marcia S, Liu, Xinyu, Wright, Gerard D, de Bruijn, Irene, Aigle, Bertrand, Lautru, Sylvie, Katz, Leonard, Melnik, Alexey V, Cummings, Matthew, Monroe, Emily A, Gomez-Escribano, Juan Pablo, Haines, Anthony S, Gross, Harald, Wilkinson, Barrie, Gerwick, William H, Keller, Nancy P, Kottmann, Renzo, Brakhage, Axel A, Fewer, David P, Gerwick, Lena, Moore, Marcus, Caffrey, Patrick, Lee, Chia Y, Truman, Andrew W, Yu, Fengan, Sherman, David, Tahlan, Kapil, Wiemann, Philipp, Sivonen, Kaarina, Stegmann, Evi, Donadio, Stefano, Tang, Yi, Rui, Zhe, Mast, Yvonne, Greule, Anja, Nett, Markus, Kötter, Peter, Bode, Helge B, Hertweck, Christian, Linquan, Bai, Smanski, Michael J, Brady, Sean F, Weber, Tilmann, Yilmaz, Pelin, Blin, Kai, Cox, Russell J, Metsä-Ketelä, Mikko, Jones, Carla S, Mahmud, Taifo, Helfrich, Eric J N, Zhang, Changsheng, Höfte, Monica, Kwon, Hyung-Jin, Masschelein, Joleen, Jensen, Susan E, Cruz-Morales, Pablo, Mantovani, Simone M, Reen, F Jerry, Petricek, Miroslav, Entian, Karl-Dieter, Süssmuth, Roderich D, Clardy, Jon, Jones, Adam C, Claesen, Jan, Kyrpides, Nikos C, Ju, Jianhua, Wyckoff, Elizabeth, Micklefield, Jason, Dorrestein, Pieter C, Takano, Eriko, Hillwig, Matthew L, Rosconi, Federico, Borriss, Rainer, Donia, Mohamed S, Moss, Nathan, Jungmann, Katrin, Kuzuyama, Tomohisa, Wohlleben, Wolfgang, Krug, Daniel, Glöckner, Frank Oliver, Gust, Bertolt, Apel, Alexander K, Zotchev, Sergey B, O, Fergal, van Wezel, Gilles P, Tsunematsu, Yuta, Walton, Jonathan D, Ehling-Schulz, Monika, Kuipers, Oscar P, Edwards, Daniel J, Yan, Xiaohui, Duddela, Srikanth, Driessen, Arnold J M, Méndez, Carmen, Sosio, Margherita, Osbourn, Anne, Chooi, Yit Heng, Kim, Hyun Uk, Salas, José A, Kegler, Carsten, Medema, Marnix H, Ostash, Bohdan, Coates, R Cameron, Lavigne, Rob, Walsh, Christopher, Balibar, Carl J, Doyle, Sean, Mitchell, Douglas A, Liu, Wen, Garg, Neha, Tian, Zhenhua, Müller, Rolf, Breitling, Rainer, Ishida, Keishi, Neilan, Brett A, Moore, Bradley S, Raaijmakers, Jos M, Nützmann, Hans-Wilhelm, Nielsen, Jens, Cheng, Yi-Qiang, Pan, Guohui, De Mot, René, Seipke, Ryan F, Barona-Gómez, Francisco, Kaysser, Leonard, Xie, Yunchang, Moreira, Leonilde M, Thomas, Christopher M, Oikawa, Hideaki, van der Donk, Wilfred A, Piel, Jörn, Willey, Joanne M, Fischbach, Michael A, Shen, Ben, Biggins, John B, Ziemert, Nadine, Luzhetskyy, Andriy, Schmitt, Esther K, Pati, Amrita, Pernodet, Jean-Luc, Tobias, Nicholas J, Klassen, Jonathan L, Balskus, Emily, Hadjithomas, Michalis, Bechthold, Andreas   +153 more
core   +1 more source

Cloning and characterization of the biosynthetic gene cluster for kutznerides [PDF]

Proceedings of the National Academy of Sciences, 2007
Kutznerides, actinomycete-derived cyclic depsipetides, consist of six nonproteinogenic residues, including a highly oxygenated tricyclic hexahydropyrroloindole, a chlorinated piperazic acid, 2-(1-methylcyclopropyl)-glycine, a β-branched-hydroxy acid, and 3-hydroxy glutamic acid, for which biosynthetic logic has not been elucidated.
Danica Galonic, Fujimori, Sinisa, Hrvatin, Christopher S, Neumann, Matthias, Strieker, Mohamed A, Marahiel, Christopher T, Walsh   +5 more
openaire   +2 more sources

Marine Microbial-Derived Resource Exploration: Uncovering the Hidden Potential of Marine Carotenoids

Marine Drugs, 2022
Microbes in marine ecosystems are known to produce secondary metabolites. One of which are carotenoids, which have numerous industrial applications, hence their demand will continue to grow.
Ray Steven, Zalfa Humaira, Yosua Natanael, Fenny M. Dwivany, Joko P. Trinugroho, Ari Dwijayanti, Tati Kristianti, Trina Ekawati Tallei, Talha Bin Emran, Heewon Jeon, Fahad A. Alhumaydhi, Ocky Karna Radjasa, Bonglee Kim   +12 more
doaj   +1 more source

The erythromycin biosynthetic gene cluster of Aeromicrobium erythreum

Journal of Industrial Microbiology & Biotechnology, 2004
The erythromycin-biosynthetic (ery) gene cluster of Aeromicrobium erythreum was cloned and characterized. The 55.4-kb cluster contains 25 ery genes. Homologues were found for each gene in the previously characterized ery gene cluster from Saccharopolyspora erythraea. In addition, four new predicted ery genes were identified.
Igor A, Brikun, Andrew R, Reeves, William H, Cernota, Minh B, Luu, J Mark, Weber   +4 more
openaire   +2 more sources

Biosynthetic gene clusters and the evolution of fungal chemodiversity

Natural Product Reports, 2020
This highlight synthesizes knowledge of the molecular evolutionary processes – functional divergence, horizontal transfer, and de novo assembly – that govern biosynthetic gene cluster diversification and the generation of chemodiversity in fungi.
Antonis Rokas, Matthew E. Mead, Jacob L. Steenwyk, Huzefa A. Raja, Nicholas H. Oberlies   +4 more
openaire   +3 more sources