Results 31 to 40 of about 373,234 (333)

In silico analyses of maleidride biosynthetic gene clusters [PDF]

Fungal Biology and Biotechnology, 2021
Abstract Maleidrides are a family of structurally related fungal natural products, many of which possess diverse, potent bioactivities. Previous identification of several maleidride biosynthetic gene clusters, and subsequent experimental work, has determined the ‘core’ set of genes required to construct the ...
Katherine Williams, Kate M. J. de Mattos-Shipley, Christine L. Willis, Andrew M. Bailey   +3 more
openaire   +6 more sources

Identification of a Biosynthetic Gene Cluster in Rice for Momilactones [PDF]

Journal of Biological Chemistry, 2007
Rice diterpenoid phytoalexins such as momilactones and phytocassanes are produced in suspension-cultured rice cells treated with a chitin oligosaccharide elicitor and in rice leaves irradiated with UV light. The common substrate geranylgeranyl diphosphate is converted into diterpene hydrocarbon precursors via a two-step sequential cyclization and then ...
Kazuhiro, Shimura, Atsushi, Okada, Kazunori, Okada, Yusuke, Jikumaru, Kwang-Wook, Ko, Tomonobu, Toyomasu, Takeshi, Sassa, Morifumi, Hasegawa, Osamu, Kodama, Naoto, Shibuya, Jinichiro, Koga, Hideaki, Nojiri, Hisakazu, Yamane   +12 more
openaire   +2 more sources

Cloning and characterization of the biosynthetic gene cluster for kutznerides [PDF]

Proceedings of the National Academy of Sciences, 2007
Kutznerides, actinomycete-derived cyclic depsipetides, consist of six nonproteinogenic residues, including a highly oxygenated tricyclic hexahydropyrroloindole, a chlorinated piperazic acid, 2-(1-methylcyclopropyl)-glycine, a β-branched-hydroxy acid, and 3-hydroxy glutamic acid, for which biosynthetic logic has not been elucidated.
Danica Galonic, Fujimori, Sinisa, Hrvatin, Christopher S, Neumann, Matthias, Strieker, Mohamed A, Marahiel, Christopher T, Walsh   +5 more
openaire   +2 more sources

Mining biosynthetic gene clusters in Virgibacillus genomes [PDF]

BMC Genomics, 2019
Biosynthetic gene clusters produce a wide range of metabolites with activities that are of interest to the pharmaceutical industry. Specific interest is shown towards those metabolites that exhibit antimicrobial activities against multidrug-resistant bacteria that have become a global health threat.
Ghofran Othoum, Salim Bougouffa, Ameerah Bokhari, Feras F. Lafi, Takashi Gojobori, Heribert Hirt, Ivan Mijakovic, Vladimir B. Bajic, Magbubah Essack   +8 more
openaire   +6 more sources

Formation and diversification of a paradigm biosynthetic gene cluster in plants

Nature Communications, 2020
Numerous examples of biosynthetic gene clusters (BGCs), including for compounds of agricultural and medicinal importance, have now been discovered in plant genomes.
Zhenhua Liu, Jitender Cheema, Marielle Vigouroux, L. Hill, James Reed, Pirita Paajanen, Levi Yant, A. Osbourn   +7 more
semanticscholar   +1 more source

Identification, heterologous expression, and characterization of the tolypodiol biosynthetic gene cluster through an integrated approach.

, 2023
Cyanobacteria are tremendous producers of biologically active natural products including the potent anti-inflammatory compound tolypodiol. However, linking biosynthetic gene clusters with compound production in cyanobacteria has lagged behind other ...
Philip , Williams, Timothy J., O\u27Donnell, Kyle , Axt, Benjamin, Philmus, Daniel, Back, Juan , Vanegas, Joshua , Gurr   +6 more
core   +1 more source

Chromatin-level regulation of biosynthetic gene clusters [PDF]

Nature Chemical Biology, 2009
Loss-of-function Aspergillus nidulans CclA, a Bre2 ortholog involved in histone H3 lysine 4 methylation, activated the expression of cryptic secondary metabolite clusters in A. nidulans. One new cluster generated monodictyphenone, emodin and emodin derivatives, whereas a second encoded two anti-osteoporosis polyketides, F9775A and F9775B.
Jin Woo, Bok, Yi-Ming, Chiang, Edyta, Szewczyk, Yazmid, Reyes-Dominguez, Ashley D, Davidson, James F, Sanchez, Hsien-Chun, Lo, Kenji, Watanabe, Joseph, Strauss, Berl R, Oakley, Clay C C, Wang, Nancy P, Keller   +11 more
openaire   +2 more sources

Heterologous Expression of the Unusual Terreazepine Biosynthetic Gene Cluster Reveals a Promising Approach for Identifying New Chemical Scaffolds

mBio, 2020
Advances in genome sequencing have revitalized natural product discovery efforts, revealing the untapped biosynthetic potential of fungi. While the volume of genomic data continues to expand, discovery efforts are slowed due to the time-consuming nature ...
Lindsay K. Caesar, Matthew T. Robey, Michael Swyers, Md N. Islam, Rosa Ye, Purav P. Vagadia, Gary E. Schiltz, Paul M. Thomas, Chengcang C. Wu, Neil L. Kelleher, Nancy P. Keller, Jin Woo Bok   +11 more
doaj   +1 more source

Cloning of the Bisucaberin B Biosynthetic Gene Cluster from the Marine Bacterium Tenacibaculum mesophilum, and Heterologous Production of Bisucaberin B

Marine Drugs, 2018
The biosynthetic gene cluster for bisucaberin B (1, bsb gene cluster), an N-hydroxy-N-succinyl diamine (HSD)-based siderophore, was cloned from the marine bacterium Tenacibaculum mesophilum, originated from a marine sponge.
Masaki J. Fujita, Yusuke Goto, Ryuichi Sakai   +2 more
doaj   +1 more source

Characterization of the Ergosterol Biosynthesis Pathway in Ceratocystidaceae

Journal of Fungi, 2021
Terpenes represent the biggest group of natural compounds on earth. This large class of organic hydrocarbons is distributed among all cellular organisms, including fungi.
Mohammad Sayari, Magrieta A. van der Nest, Emma T. Steenkamp, Saleh Rahimlou, Almuth Hammerbacher, Brenda D. Wingfield   +5 more
doaj   +1 more source