Results 31 to 40 of about 3,454,458 (298)

One Pathway, Two Cyclic Non-Ribosomal Pentapeptides: Heterologous Expression of BE-18257 Antibiotics and Pentaminomycins from Streptomyces cacaoi CA-170360

Microorganisms, 2021
The strain Streptomyces cacaoi CA-170360 produces the cyclic pentapeptides pentaminomycins A–H and BE-18257 A–C, two families of cyclopeptides synthesized by two non-ribosomal peptide synthetases encoded in tandem within the same biosynthetic gene ...
Fernando Román-Hurtado, Marina Sánchez-Hidalgo, Jesús Martín, Francisco Javier Ortiz-López, Daniel Carretero-Molina, Fernando Reyes, Olga Genilloud   +6 more
doaj   +1 more source

Molecular genetical analysis of the nitrate gene cluster of Aspergillus nidulans [PDF]

, 2015
Putative DNA clones harbouring the nitrate gene cluster of Aspergillus nidulans was used in a number of transformation experiments to positively identify the clones.
Greaves, Philip Andrew
core   +2 more sources

Expanding our understanding of sequence-function relationships of type II polyketide biosynthetic gene clusters: bioinformatics-guided identification of Frankiamicin A from Frankia sp. EAN1pec. [PDF]

PLoS ONE, 2015
A large and rapidly increasing number of unstudied "orphan" natural product biosynthetic gene clusters are being uncovered in sequenced microbial genomes.
Yasushi Ogasawara, Benjamin J Yackley, Jacob A Greenberg, Snezna Rogelj, Charles E Melançon   +4 more
doaj   +1 more source

Identification of a Novel Biosynthetic Gene Cluster in Aspergillus niger Using Comparative Genomics

Journal of Fungi, 2021
Previously, DNA microarrays analysis showed that, in co-culture with Bacillus subtilis, a biosynthetic gene cluster anchored with a nonribosomal peptides synthetase of Aspergillus niger is downregulated.
Gregory Evdokias, Cameron Semper, Montserrat Mora-Ochomogo, Marcos Di Falco, Thi Truc Minh Nguyen, Alexei Savchenko, Adrian Tsang, Isabelle Benoit-Gelber   +7 more
doaj   +1 more source

Identification of a Biosynthetic Gene Cluster in Rice for Momilactones [PDF]

Journal of Biological Chemistry, 2007
Rice diterpenoid phytoalexins such as momilactones and phytocassanes are produced in suspension-cultured rice cells treated with a chitin oligosaccharide elicitor and in rice leaves irradiated with UV light. The common substrate geranylgeranyl diphosphate is converted into diterpene hydrocarbon precursors via a two-step sequential cyclization and then ...
Kazuhiro, Shimura, Atsushi, Okada, Kazunori, Okada, Yusuke, Jikumaru, Kwang-Wook, Ko, Tomonobu, Toyomasu, Takeshi, Sassa, Morifumi, Hasegawa, Osamu, Kodama, Naoto, Shibuya, Jinichiro, Koga, Hideaki, Nojiri, Hisakazu, Yamane   +12 more
openaire   +2 more sources

Реконструкція філогенії кластерів генів біосинтезу глікопептидів

Фактори експериментальної еволюції організмів, 2017
Aim. In current study we have endeavored to analyze the phylogeny of 18 sequenced glycopeptide biosynthetic gene clusters. Methods. Standard methods of phylogenetic reconstruction were used in this research. Results. We have created sets of conservative
O. S. Yushchuk, B. O. Ostash, L. O. Horbal, V. O. Fedorenko   +3 more
doaj   +1 more source

Evolution and Diversity of Biosynthetic Gene Clusters in Fusarium

Frontiers in Microbiology, 2018
Plant pathogenic fungi in the Fusarium genus cause severe damage to crops, resulting in great financial losses and health hazards. Specialized metabolites synthesized by these fungi are known to play key roles in the infection process, and to provide survival advantages inside and outside the host.
Koen Hoogendoorn, Koen Hoogendoorn, Lena Barra, Cees Waalwijk, Jeroen S. Dickschat, Theo A. J. van der Lee, Marnix H. Medema   +6 more
openaire   +4 more sources

ArpA-like regulatory control and discovery of new biosynthetic genes driving scleric acid biosynthesis [PDF]

RSC Chemical Biology
Scleric acid is a natural product that was discovered by heterologous expression of the silent scl gene cluster from Streptomyces sclerotialus in Streptomyces albidoflavus and rational de-repression of the biosynthetic genes through deletion of the ArpA ...
Jingfan Zhang, Lijiang Song, Manuela Tosin, Christophe Corre, Fabrizio Alberti   +4 more
doaj   +1 more source

The insect pathogen Serratia marcescens Db10 uses a hybrid non-ribosomal peptide synthetase-polyketide synthase to produce the antibiotic althiomycin [PDF]

, 2012
There is a continuing need to discover new bioactive natural products, such as antibiotics, in genetically-amenable micro-organisms. We observed that the enteric insect pathogen, Serratia marcescens Db10, produced a diffusible compound that inhibited the
Coulthurst Sarah J., Challis Gregory L., Stanley-Wall, Nicola R; id_orcid, Gregory L Challis, Gerc, Amy J., Amy J. Gerc, Gerc Amy J., Nicola R Stanley-Wall, Gregory L. Challis (136140), Song Lijiang, Coulthurst, Sarah J; id_orcid, Sarah J. Coulthurst, Lijiang Song (136135), Lijiang Song, Stanley-Wall, Nicola R., Stanley-Wall Nicola R., Coulthurst, Sarah J., Nicola R. Stanley-wall, Challis, Gregory L., Challis, Gregory L, Amy J Gerc, Sarah J. Coulthurst (136148), Song, Lijiang, Gerc, Amy J, Amy J. Gerc, Amy J. Gerc (136131), Nicola R. Stanley-Wall (136144), Sarah J Coulthurst, Gregory L. Challis   +28 more
core   +2 more sources

The Biosynthetic Gene Cluster for Andrastin A in Penicillium roqueforti [PDF]

Frontiers in Microbiology, 2017
Penicillium roqueforti is a filamentous fungus involved in the ripening of several kinds of blue cheeses. In addition, this fungus produces several secondary metabolites, including the meroterpenoid compound andrastin A, a promising antitumoral compound.
Rojas Aedo, Juan F., Gil Durán, Carlos, Del-Cid, Abdiel, Valdés, Natalia, Álamos, Pamela, Vaca Cerezo, Inmaculada, García Rico, Ramón O., Levicán, Gloria, Tello, Mario, Chávez, Renato   +9 more
openaire   +4 more sources