Results 11 to 20 of about 373,234 (333)

Minimum Information about a Biosynthetic Gene cluster [PDF]

Nature Chemical Biology, 2015
A wide variety of enzymatic pathways that produce specialized metabolites in bacteria, fungi and plants are known to be encoded in biosynthetic gene clusters.
Tilmann Weber, Düsterhus, Stephanie, Brady, Sean, Zotchev, Sergey B., Haines, A., Haines, A. S., Seipke, R. F., Willey, J.M., Carla S Jones, Lee, C. Y., Neha Garg, Bode, H., Andreas Bechthold, Leonilde M Moreira, De Bruijn, I.,, Pernodet, Jean Luc, Caffrey, P., Aigle, B., Jan Claesen, Monroe, E.A., Sherman, David H, Fewer, D. P.,, Fergal O'Gara, Fischbach, Michael A., Yu, F., Kim, H., Payne, Shelley M., Gust, B.,, Bruijn, Irene, De, Bertolt Gust, Breitling, R., Balskus, Emily P., Linquan, Bai, Metsä-Ketelä, Mikko, Osburne, M. S., De Mot, Rene, Zhang, Changsheng, Kegler, C.,, Ploux, O., Lautru, S., Harald Gross, Entian, Karl-Dieter, Van Der Donk, W. A.,, Jones, C. S., Wyckoff, Elizabeth, Dorrestein, Pieter C, Driessen, Arnold JM, Rosconi, Federico, Hillwig, Matthew L, Yvonne Mast, Borriss, Rainer, Keller, Nancy P., Douglas A Mitchell, Borriss, R.,, Kuzuyama, T.,, Mast, Yi, Dorrestein, P.C., Viaud, M.,, van Wezel, Gilles P, Yan, Xiaohui, Edwards, Daniel J, Breitling, R.,, Katz, L., Tobias, Nicholas J., Driessen, Arnold J M, Pan, G., Zotchev, S. B., Kwon, H. J.,, Helfrich, E.J.N., Donadio, S.,, Pati, A., Yim, G., Doyle, Sean, Viaud, Muriel,, Michael J Smanski, Carsten Kegler, Eric J N Helfrich, R Cameron Coates, Tahlan, K., Jensen, S. E., Tian, Zhenhua, Michalis Hadjithomas, Fewer, D., Höfte, M.,, Petras, D.,, Walsh, Christopher T, Moreira, L. M., Cheng, Yi-Qiang, Schmitt, E.K., Karl-Dieter Entian, Rob Lavigne, Smanski, M. J., Mueller, Rolf, Irene de Bruijn, Fischbach, M., Gerwick, W. H.,, van der Donk, Wilfred A, Willey, Joanne M, Biggins, John B, Kaysser, L.,, Ben Shen, Chooi, Y. H., Seipke, Ryan F., Neilan, Brett A., Seipke, R.F., Payne, Shelley M, Miroslav Petricek, Melnik, Alexey V., Chia Y Lee, Barona-Gómez, F.,, Scott, Barry, Petras, Daniel, Süssmuth, Roderich D., Kötter, P.,, Sergey B Zotchev, Axel A Brakhage, Wilkinson, Barrie, Gilles P van Wezel, Gerwick, William H, Dorrestein, P. C.,, Monica Höfte, Brakhage, Axel A, Yan, X.,, Gerwick, Lena, Edwards, Daniel J., Driessen, A. J. M., Chooi, Y., Klassen, J.L., Moore, M.,, Takano, E.,, Wiemann, Philipp, Micklefield, J., Adam C Jones, Yit Heng Chooi, Andriy Luzhetskyy, Donadio, S., Balskus, Emily P, Zhenhua Tian, Ju, J., Osbourn, A., Walsh, C. T.,, Glöckner, F. O., Renzo Kottmann, Tobias, N.J., Wyckoff, E., Helfrich, Eric J N, Cox, R.J., Garg, N.,, Jones, A. C., Donk, Wilfred A., Van Der, Wezel, Gilles P., Van, Cruz-Morales, Pablo, Hillwig, M. L.,, Kyrpides, Nikos C, Mantovani, S.M., Süssmuth, R.D., Shen, B., Brady, S., Jungmann, Katrin, Duesterhus, Stephanie, Pablo Cruz-Morales, Moss, N., Liu, W.,, Scott, B.,, Brady, S. F.,, Tsunematsu, Yuta, Nikos C Kyrpides, Salas, J. A.,, Eriko Takano, Kottmann, R., Zhe Rui, Luzhetskyy, A., Krug, D.,, Biggins, J. B., Srikanth Duddela, Walsh, C.T., Donia, M., Cox, R., Sosio, Margherita, Neilan, B. A.,, Kegler, Carsten, Grace Yim, Donia, M.S., Garg, N., Petricek, M., Frank Oliver Glöckner, Süssmuth, R. D., Micklefield, J.,, Reen, F. J.,, Ehling-Schulz, M., De Mot, R.,, Petricek, M.,, Carl J Balibar, Federico Rosconi, Hyung-Jin Kwon, Walton, Jonathan D., Bode, Helge B., Mantovan, Simone M., Biggins, J., Claesen, J.,, Nuetzmann, Hans-Wilhelm, Jones, Carla S., Mantovani, Simone M., Balibar, C.J., Gross, H.,, Chooi, Yi, Takano, Eriko; id_orcid, Yim, Grace, Brady, S.F., Doyle, S.,, Medema, M. H., Balibar, Carl J., Shelley M Payne, Jean-Luc Pernodet, Mahmud, T., Osburne, M. S.,, Balibar, C. J., Kai Blin, Medema, M.H., Donk, Wilfred A van der, Walton, J.D., Wright, Gerard D., Keller, N. P., Haines, Anthony S, Esther K Schmitt, Dorrestein, Pieter C., Helfrich, Eric J.N., Moore, Marcus, K\uf6tter, P., Kai, Blin, Jörn Piel, William H Gerwick, Van Wezel, G. P.,, Donadio, Stefano, Stefano Donadio, Edwards, D. J.,, Thomas, C.M., Nielsen, J., Haines, Anthony S., Walsh, Christopher T., Bode, Helge B, Yilmaz, Pelin, Kaysser, L., Méndez, C., Guohui Pan, Matthew L Hillwig, Medema, M. H.,, Biggins, John B., Tian, Z.,, Claesen, J., Jensen, Susan E., Ryan F Seipke, Monroe, Emily A., Bode, H.B., Rosconi, F.,, Gust, B., Ehling-Schulz, M.,, Melnik, A., Takano, Eriko, Bechthold, A., Cummings, M.,, Nützmann, H-W., Haines, A. S.,, Payne, S. M.,, Wohlleben, Wolfgang, Simone M Mantovani, Juan Pablo Gomez-Escribano, Leonard Kaysser, David P Fewer, Nathan Moss, Truman, A. W., Evi Stegmann, Ehling-Schulz, Monika, Donia, M. S., Cheng, Yi Qiang, Kim, H.U., Fischbach, M.A., Brakhage, A. A.,, F Jerry Reen, Moore, B. S.,, Balibar, Carl J, Liu, Wen, Hillwig, M. L., Nützmann, H. W.,, Jones, Jon, Hertweck, C.,, Ishida, Keishi, Neilan, Brett A, Roderich D Süssmuth, Moore, Bradley S, David H Sherman, Monroe, E. A., Nielsen, Jens, Mot, René De, Yi Tang, Daniel Petras, Walton, J. D., Shen, B.,, Smanski, M. J.,, Nicholas J Tobias, Gomez-Escribano, J., Fischbach, Michael A, Duddela, S.,, Wright, G.D., Schmitt, Esther K, Yilmaz, P.,, Yu, F.,, Jonathan D Walton, Ju, Katrin, Mitchell, D. A.,, Nadine Ziemert, Oscar P Kuipers, Jones, A., Russell J Cox, Gl\uf6ckner, F. O., de Bruijn, Irene, Lee, C.Y., Kuipers, O.P., Gross, Harald, Gerwick, L., Zotchev, S. B.,, Kottmann, Renzo, Hideaki Oikawa, Düsterhus, S.,, Mast, Y.,, Salas, José A., Caffrey, Patrick, D\ufcsterhus, S., Truman, Andrew W, Bruijn, Irene de, Jones, Adam C., Yu, Fengan, Nielsen, Jens B,, Tang, Yi, Nielsen, Jens B., Rui, Zhe, Wezel, G.P. van, Katz, L.,, Rolf Müller, Hyun Uk Kim, Jones, C., Hertweck, Christian, Geiger, C.,, Petras, D., Mahmud, Taifo, Pernodet, J-L., Wright, G. D., O'Gara, F.,, Düsterhus, S., Moss, N.,, Entian, K. D.,, Tang, Y.,, M\ufcller, R., Entian, K.D., Smanski, M.J., Donia, Mohamed S, Moss, Nathan, Lavigne, R., Kuzuyama, Tomohisa, Pernodet, J. L., Salas, J. A., Ishida, K.,, Ostash, B.,, Stegmann, E., Jones, C.S., Hillwig, M., Gust, Bertolt, Apel, Alexander K, Kim, H. U.,, Hadjithomas, M., Greule, A.,, Thomas, Christopher M., Gerwick, William H., Klassen, J. L., Gomez-Escribano, J. P.,, Lavigne, R.,, Jonathan L Klassen, Osbourn, A.,, Lavigne, Rob, Jensen, Jens, Tobias, N., Donia, M. S.,, Jos M Raaijmakers, Wezel, Gilles P van, Breitling, Rainer, Glöckner, F. O.,, Walsh, C. T., Carmen Méndez, Brett A Neilan, Yuta Tsunematsu, Changsheng Zhang, Schmitt, Esther, Nützmann, Hans Wilhelm, Jason Micklefield, Amrita Pati, Neilan, B.A., Metsä-Ketelä, M., Yu, Yuta, Barona-Gómez, Francisco, Driessen, Arnold J.M., Ziemert, N.,, Thomas, Christopher M, Biggins, J.B., Mantovani, S. M.,, Kuipers, Oscar P., Jungmann, K.,, Barona-G\uf3mez, F., Hans-Wilhelm Nützmann, Luzhetskyy, Andriy, Tian, Z., Bechthold, A.,, Kwon, H.J., Pernodet, Jean-Luc, Koetter, Peter, Tang, Y., Marnix H Medema, Rui, Z.,, Stephanie Düsterhus, Geiger, Christoph, Mitchell, D.A., O’Gara, Fergal, Christopher T Walsh, Osburne, Marcia S, Wright, Gerard D, Aigle, Bertrand, Moore, Jon, M\ue9ndez, C., Raaijmakers, J. M., Zhang, C.,, Hillwig, M.L., Andrew W Truman, Brakhage, Axel A., Barona-Gómez, F., Luzhetskyy, Andriy N, Helfrich, E.J., Brakhage, A.A., Pieter C Dorrestein, Raaijmakers, J.M., Cheng, Y. Q., Lautru, S.,, Nützmann, H., Mast, Yvonne, Pan, G.,, Yi-Qiang Cheng, Jianhua Ju, Xie, Y.,, Nielsen, Jens B, Wilkinson, B.,, Anthony S Haines, Kötter, Peter, Kuipers, O. P., Christoph Geiger, Medema, M., Smanski, Michael J, Linquan, B., Weber, Tilmann, Brady, Sean F, Krug, D., Höfte, Monica, Joanne M Willey, Jensen, S.E., Mantovani, Simone M, Süssmuth, Roderich D, Wolfgang Wohlleben, Jones, Adam C, Ju, Jianhua, Kwon, Hyung Jin, Micklefield, Jason, Kegler, C., Moore, B. S., Gerard D Wright, Jens Nielsen, Krug, Daniel, Moreira, L.M., Ploux, O.,, Cheng, Y., Sherman, D.H., De Bruijn, I., Apel, A. K.,, Kuipers, O. P.,, Fewer, D. P., Viaud, M., Moreira, Leonilde M., Osbourn, Anne, Balskus, E. P., Entian, K., Kyrpides, Nikos C., Entian, K-D., Medema, Marnix H, Melnik, A. V., Ostash, Bohdan, Driessen, A. J. M.,, Apel, A.K., Nützmann, H. W., Weber, T., Tahlan, K.,, Wilkinson, B., Müller, Rolf, Glöckner, F.O., Yunchang Xie, Wilfred A van der Donk, Hadjithomas, M.,, Truman, Andrew W., Cheng, Yo, Kuipers, Oscar P; id_orcid, Van Der Donk, W., Anne Osbourn, Biggins, J. B.,, Tsunematsu, Y.,, Nett, M., Kyrpides, N.C., O Gara, Fergal, Moore, B.S., Bode, H. B., Weber, T.,, Donia, Mohamed S., Moore, M., Thomas, Christopher; id_orcid, Bohdan Ostash, Driessen, Arnold J. M., Pati, A.,, Müller, R.,, Cheng, Yi, Méndez, C.,, Emily P Balskus, Cox, R. J., Masschelein, J.,, Brakhage, A., Yim, G.,, Ploux, Olivier, Tobias, N. J., Cox, Russell, Xiaohui Yan, Kyrpides, N. C.,, Fischbach, M. A., Kwon, H. J., Cummings, M., Nancy P Keller, Wohlleben, W.,, Yan, X., Reen, F. Jerry, Keller, Nancy P, Barrie Wilkinson, Rosconi, F., Mikko Metsä-Ketelä, Yim, Yi, Fewer, David P, Wen Liu, Christian Hertweck, Jensen, S. E.,, Helfrich, E. J. N., Piel, J., Tahlan, Kapil, Sherman, D. H., Sivonen, Kaarina, Stegmann, Evi, Cruz-Morales, P., Apel, A. K., Edwards, D. J., O'Gara, F., Wiemann, P.,, Sherman, David H., Dorrestein, P., Cox, Russell J, Entian, Karl Dieter, Mitchell, Douglas A., Scott, B., Kwon, Hyung-Jin, Willey, J. M.,, Driessen, A., Reen, F Jerry, Petricek, Miroslav, Dorrestein, P. C., Marcus Moore, Gomez-Escribano, J. P., Mitchell, D. A., Sean Doyle, Kormanec, J.,, Sivonen, K.,, René De Mot, Glöckner, Frank Oliver, Bertrand Aigle, Zotchev, S.B., Bode, Helge Björn, Christopher M Thomas, Wiemann, P., Francisco Barona-Gómez, Rainer Borriss, Walton, Jonathan D, Duddela, Srikanth, S\ufcssmuth, R. D., Salas Fernández, José Antonio, Driessen, A.J., Schmitt, Esther K., Rui, Z., Alexander K Apel, Duddela, S., Coates, R Cameron, H\uf6fte, M., Kaarina Sivonen, Mitchell, Douglas A, Kyrpides, N. C., Anja Greule, Yilmaz, Yi, Liu, X.,, Müller, R., Hertweck, C., Ju, Juan Pablo, Bai Linquan, Doyle, S., Balskus, E.P., Raaijmakers, Jos M, Sosio, M., Luzhetskyy, A.,, Nützmann, Hans-Wilhelm, Nett, M.,, Helfrich, E., Pan, Guohui, Seipke, Ryan F, Susan E Jensen, Driessen, A.J.M., Xie, Yunchang, Marcia S Osburne, Greule, A., Piel, Jörn, Shen, Ben, Schmitt, E. K., Kapil Tahlan, Willey, Joanne M., Apel, A., Aigle, B.,, Pati, Amrita, Hillwig, Matthew L., Gerwick, W., Bechthold, Andreas, Gloeckner, Frank Oliver, Mantovani, S., Melnik, A. V.,, Jon Clardy, Truman, A.W., Seipke, R. F.,, Keller, N. P.,, Liu, Xinyu, Gerwick, W. H., José A Salas, Lautru, Sylvie, Schmitt, E. K.,, Arnold J M Driessen, Melnik, Alexey V, Mot, René, De, Edwards, Daniel, Gomez-Escribano, Juan Pablo, Masschelein, J., Oikawa, H.,, Keller, N.P., Monroe, E. A.,, Helfrich, Eric JN, Joleen Masschelein, Moore, Bradley S., Reen, F., Melnik, A.V., Stegmann, E.,, Borriss, R., Linquan, B.,, Lee, Chia Y, Reen, F.J., Sherman, D. H.,, Osburne, Marcia S., Monroe, E., Daniel Krug, Smanski, Michael J., Caffrey, P.,, Kormanec, J., Salas, Jose A, Cruz-Morales, P.,, Kötter, P., Masschelein, Joleen, Jensen, Susan E, Piel, Joern, van Wezel, G.P., Oikawa, H., Rainer Breitling, Cheng, Y. Q.,, Tobias, N. J.,, Medema, Marnix H., Gerwick, W.H., Coates, R.C., Jungmann, K., Méndez Fernández, María del Carmen, Geiger, C., Margherita Sosio, Moreira, L. M.,, Van Der Donk, W. A., Ishida, K., Neilan, B. A., Kuipers, Oscar P, Brady, Sean F., Sylvie Lautru, Kottmann, R.,, Coates, R. C., Peter Kötter, Cox, R. J.,, Lee, C. Y.,, Keishi Ishida, Balskus, E. P.,, Chooi, Yit Heng, Kim, Hyun Uk, Mets\ue4-Ketel\ue4, M., Höfte, M., Zhang, C., Balibar, C., Nützmann, H.W., Willey, J. M., Lee, Chia Y., Pernodet, J. L.,, Apel, Alexander K., Pelin Yilmaz, Gross, H., Brady, S. F., Katrin Jungmann, O\u27Gara, F., van der Donk, W.A., Wyckoff, E.,, John B Biggins, Thomas, Christopher M.; id_orcid, Ju, Guohui, Jones, A. C.,, Coates, R. C.,, Emily A Monroe, Cox, Russell J., Markus Nett, Balibar, C. J.,, Sivonen, K., Blin, K.,, Takano, E., Coates, R. Cameron, Ziemert, Nadine, Fengan Yu, Coates, R., Reen, F. J., Clardy, J., Jones, A.C., Haines, A.S., Walton, J. D.,, Leonard Katz, Edwards, D., Bode, H. B.,, Monika Ehling-Schulz, Fewer, D.P., Osburne, M.S., Klassen, Jonathan L., Viaud, Muriel, Yilmaz, P., Kormanec, Jan, Entian, K. D., Katz, Leonard, Pernodet, J.L., Cummings, Matthew, Monroe, Emily A, Van Wezel, G. P., Tomohisa Kuzuyama, Daniel J Edwards, Suessmuth, Roderich D, Xie, Y., Schmitt, J.K., Barry Scott, Edwards, D.J., Gomez-Escribano, J.P., Süssmuth, R. D.,, Blin, K., Kuzuyama, T., Greule, Anja, Tsunematsu, Y., Nett, Markus, Klassen, J. L.,, Piel, J.,, Raaijmakers, Jos M., Helfrich, E. J. N.,, Blin, Kai, Jones, Carla S, Mast, Y., Payne, S.M., Mantovani, S. M., Fewer, David P., Bradley S Moore, Clardy, Jon, Claesen, Jan, Wright, G. D.,, Thomas, C. M.,, Truman, A. W.,, Sean F Brady, Jan Kormanec, Patrick Caffrey, Muriel Viaud, Raaijmakers, J. M.,, Thomas, C. M., Helfrich, Eric J. N., Alexey V Melnik, Salas, J.A., Payne, S. M., Clardy, J.,, Zotchev, Sergey B, Tang, Yihan, Ostash, B., Lena Gerwick, Gerwick, L.,, Brakhage, A. A., Chooi, Y.H., Ju, J.,, Liu, W., Méndez, Carmen, Matthew Cummings, Mahmud, T.,, Kwon, H-J., Elizabeth Wyckoff, Michael A Fischbach, Garg, Neha, van der Donk, Wilfred A., N\ufctzmann, H. W., Chooi, Y. H.,, Liu, X., Cheng, Y-Q., Metsä-Ketelä, M.,, De Mot, R., Jones, C. S.,, Mohamed S Donia, Kim, H. U., Ziemert, N., Kaysser, Leonard, Moreira, Leonilde M, Oikawa, Hideaki, Fischbach, M. A.,, Wohlleben, W., van Wezel, Gilles P., Helge B Bode, Sosio, M.,, Olivier Ploux, Ju, Xiaohui, Taifo Mahmud, Tobias, Nicholas J, Klassen, Jonathan L, Xinyu Liu, Philipp Wiemann, Hadjithomas, Michalis, Balskus, E., O'Gara, Fergal   +845 more
core   +21 more sources

Characterization of the Actinonin Biosynthetic Gene Cluster

ChemBioChem, 2018
Wolf F, Leipoldt F, Kulik A, Wibberg D, Kalinowski J, Kaysser L. Characterization of the Actinonin Biosynthetic Gene Cluster. CHEMBIOCHEM. 2018;19(11):1189-1195.The hydroxamate moiety of the natural product actinonin mediates inhibition of ...
Kaysser, Leonard, Kulik, Andreas, Wibberg, Daniel, Leipoldt, Franziska, Felix Wolf, Andreas Kulik, Leonard Kaysser, Wolf, Felix, Franziska Leipoldt, Daniel Wibberg, Kalinowski, Jörn, Jörn Kalinowski   +11 more
core   +4 more sources

MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration. [PDF]

Nucleic Acids Res
Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in agriculture, engineering and medicine.
Zdouc MM, Blin K, Louwen NLL, Navarro J, Loureiro C, Bader CD, Bailey CB, Barra L, Booth TJ, Bozhüyük KAJ, Cediel-Becerra JDD, Charlop-Powers Z, Chevrette MG, Chooi YH, D'Agostino PM, de Rond T, Del Pup E, Duncan KR, Gu W, Hanif N, Helfrich EJN, Jenner M, Katsuyama Y, Korenskaia A, Krug D, Libis V, Lund GA, Mantri S, Morgan KD, Owen C, Phan CS, Philmus B, Reitz ZL, Robinson SL, Singh KS, Teufel R, Tong Y, Tugizimana F, Ulanova D, Winter JM, Aguilar C, Akiyama DY, Al-Salihi SAA, Alanjary M, Alberti F, Aleti G, Alharthi SA, Rojo MYA, Arishi AA, Augustijn HE, Avalon NE, Avelar-Rivas JA, Axt KK, Barbieri HB, Barbosa JCJ, Barboza Segato LG, Barrett SE, Baunach M, Beemelmanns C, Beqaj D, Berger T, Bernaldo-Agüero J, Bettenbühl SM, Bielinski VA, Biermann F, Borges RM, Borriss R, Breitenbach M, Bretscher KM, Brigham MW, Buedenbender L, Bulcock BW, Cano-Prieto C, Capela J, Carrion VJ, Carter RS, Castelo-Branco R, Castro-Falcón G, Chagas FO, Charria-Girón E, Chaudhri AA, Chaudhry V, Choi H, Choi Y, Choupannejad R, Chromy J, Donahey MSC, Collemare J, Connolly JA, Creamer KE, Crüsemann M, Cruz AA, Cumsille A, Dallery JF, Damas-Ramos LC, Damiani T, de Kruijff M, Martín BD, Sala GD, Dillen J, Doering DT, Dommaraju SR, Durusu S, Egbert S, Ellerhorst M, Faussurier B, Fetter A, Feuermann M, Fewer DP, Foldi J, Frediansyah A, Garza EA, Gavriilidou A, Gentile A, Gerke J, Gerstmans H, Gomez-Escribano JP, González-Salazar LA, Grayson NE, Greco C, Gomez JEG, Guerra S, Flores SG, Gurevich A, Gutiérrez-García K, Hart L, Haslinger K, He B, Hebra T, Hemmann JL, Hindra H, Höing L, Holland DC, Holme JE, Horch T, Hrab P, Hu J, Huynh TH, Hwang JY, Iacovelli R, Iftime D, Iorio M, Jayachandran S, Jeong E, Jing J, Jung JJ, Kakumu Y, Kalkreuter E, Kang KB, Kang S, Kim W, Kim GJ, Kim H, Kim HU, Klapper M, Koetsier RA, Kollten C, Kovács ÁT, Kriukova Y, Kubach N, Kunjapur AM, Kushnareva AK, Kust A, Lamber J, Larralde M, Larsen NJ, Launay AP, Le NT, Lebeer S, Lee BT, Lee K, Lev KL, Li SM, Li YX, Licona-Cassani C, Lien A, Liu J, Lopez JAV, Machushynets NV, Macias MI, Mahmud T, Maleckis M, Martinez-Martinez AM, Mast Y, Maximo MF, McBride CM, McLellan RM, Bhatt KM, Melkonian C, Merrild A, Metsä-Ketelä M, Mitchell DA, Müller AV, Nguyen GS, Nguyen HT, Niedermeyer THJ, O'Hare JH, Ossowicki A, Ostash BO, Otani H, Padva L, Paliyal S, Pan X, Panghal M, Parade DS, Park J, Parra J, Rubio MP, Pham HT, Pidot SJ, Piel J, Pourmohsenin B, Rakhmanov M, Ramesh S, Rasmussen MH, Rego A, Reher R, Rice AJ, Rigolet A, Romero-Otero A, Rosas-Becerra LR, Rosiles PY, Rutz A, Ryu B, Sahadeo LA, Saldanha M, Salvi L, Sánchez-Carvajal E, Santos-Medellin C, Sbaraini N, Schoellhorn SM, Schumm C, Sehnal L, Selem N, Shah AD, Shishido TK, Sieber S, Silviani V, Singh G, Singh H, Sokolova N, Sonnenschein EC, Sosio M, Sowa ST, Steffen K, Stegmann E, Streiff AB, Strüder A, Surup F, Svenningsen T, Sweeney D, Szenei J, Tagirdzhanov A, Tan B, Tarnowski MJ, Terlouw BR, Rey T, Thome NU, Torres Ortega LR, Tørring T, Trindade M, Truman AW, Tvilum M, Udwary DW, Ulbricht C, Vader L, van Wezel GP, Walmsley M, Warnasinghe R, Weddeling HG, Weir ANM, Williams K, Williams SE, Witte TE, Rocca SMW, Yamada K, Yang D, Yang D, Yu J, Zhou Z, Ziemert N, Zimmer L, Zimmermann A, Zimmermann C, van der Hooft JJJ, Linington RG, Weber T, Medema MH.   +287 more
europepmc   +3 more sources

BiG-FAM: the biosynthetic gene cluster families database [PDF]

Nucleic Acids Research, 2020
Computational analysis of biosynthetic gene clusters (BGCs) has revolutionized natural product discovery by enabling the rapid investigation of secondary metabolic potential within microbial genome sequences.
S. Kautsar, K. Blin, S. Shaw, T. Weber, M. Medema   +4 more
semanticscholar   +3 more sources

The Biosynthetic Gene Cluster for Andrastin A in Penicillium roqueforti [PDF]

Frontiers in Microbiology, 2017
Penicillium roqueforti is a filamentous fungus involved in the ripening of several kinds of blue cheeses. In addition, this fungus produces several secondary metabolites, including the meroterpenoid compound andrastin A, a promising antitumoral compound.
J. F. Rojas-Aedo, C. Gil-Durán, Abdiel Del-Cid, N. Valdés, Pamela Álamos, Inmaculada Vaca, R. García-Rico, G. Levicán, Mario Tello, R. Chávez   +9 more
semanticscholar   +5 more sources

Functional Analysis of the Fusarielin Biosynthetic Gene Cluster [PDF]

Molecules, 2016
Fusarielins are polyketides with a decalin core produced by various species of Aspergillus and Fusarium. Although the responsible gene cluster has been identified, the biosynthetic pathway remains to be elucidated.
Aida Droce, Wagma Saei, Simon Hartung Jørgensen, Reinhard Wimmer, Henriette Giese, Rasmus Dam Wollenberg, Teis Esben Sondergaard, Jens Laurids Sørensen   +7 more
doaj   +4 more sources

MIBiG 3.0: a community-driven effort to annotate experimentally validated biosynthetic gene clusters [PDF]

Nucleic Acids Res., 2023
With an ever-increasing amount of (meta)genomic data being deposited in sequence databases,(meta)genome mining for natural product biosynthetic pathways occupies a critical role in the discovery of novel pharmaceutical drugs, crop protection agents and ...
Aguilar, C., Vromans, S. P. J. M., Gayrard, D., Lin, G., Lund, G., Medema, M. H., Louwen, J. J. R., Li, Y., Al-Salihi, S. A. A., Pronk, L. J. U., Robinson, S., Winter, J. M., Avelar-Rivas, J. A., Navarro-Munoz, J. C., Rego, A., Hooft, J. J. V. D., Chagas, F. O., Sing, K. S., Chevrette, M. G., Kang, K. B., Linington, R. G., Louwen, N. L., Philmus, B., Parra, J., Witte, T. E., Zaroubi, L., Aleti, G., Augustijn, H. E., Collemare, J., Lee, W-S., Kautsar, S., Zdouc, M., Torring, T., Yu, J., Bernaldo-Aguero, J., Helfrich, E. J. N., Zhong, Z., Pourmohsenin, B., Reitz, Z. L., Blin, K., Barona-Gomez, F., Cruz-Morales, P., Kalkreuter, E., Selem-Mojica, N., Rex, D. A. B., Weber, T., Kunjapur, A. M., Tang, X., Biermann, F., Terlouw, B. R., Booth, T. J., Yang, H. X. D., Duncan, K. R., Loureiro, C., Vigneshwari, A., Udwary, D., Avalon, N. E., Waschulin, V., Bielinski, V. A., Sokolova, N., Rosas-Becerra, L. R., Haslinger, K., Vind, K., Meijer, D., Gutierrez-Garcıa, K., Avitia-Domınguez, L. A., Bravo, V. J. C., Egbert, S., Williams, S. E., Roxborough, E. T., Schorn, M. A., Kim, W., Gavriilidou, A., Jati, A. P., Castelo-Branco, R., Kalyvas, N., Scobie, D. J., Alanjary, M., Santen, J. A. V., Du, C., Recchia, M. J. J.   +80 more
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Genome-wide analysis of biosynthetic gene cluster reveals correlated gene loss with absence of usnic acid in lichen-forming fungi [PDF]

Genome Biology and Evolution, 2020
Lichen-forming fungi are known to produce a large number of secondary metabolites. Some metabolites are deposited in the cortical layer of the lichen thallus where they exert important ecological functions, such as UV filtering.
Divakar P. K., Dal Grande F., Pizarro D., Lumbsch H. T., Grewe F., Crespo A.   +5 more
core   +2 more sources

Biosynthetic Gene Cluster of Linaridin Peptides Contains Epimerase Gene [PDF]

ChemBioChem, 2022
Salinipeptins belong to the type-A linaridin class of ribosomally synthesized and post-translationally modified peptides (RiPPs) comprising 22 amino acid residues with multiple D-amino acids.
Ogasawara, Yasushi, Yasuharu Satoh, Satoh, Yasuharu, Dairi, Tohru, Tohru Dairi, Xiao, Wanlu, Yasushi Ogasawara, Wanlu Xiao   +7 more
core   +4 more sources

Identification of the Scopularide Biosynthetic Gene Cluster in Scopulariopsis brevicaulis [PDF]

Marine Drugs, 2015
Scopularide A is a promising potent anticancer lipopeptide isolated from a marine derived Scopulariopsis brevicaulis strain. The compound consists of a reduced carbon chain (3-hydroxy-methyldecanoyl) attached to five amino acids (glycine, l-valine, d ...
M. B. Lukassen, Wagma Saei, T. E. Sondergaard, A. Tamminen, Abhishek Kumar, F. Kempken, M. Wiebe, J. L. Sørensen   +7 more
semanticscholar   +5 more sources