Results 11 to 20 of about 3,454,458 (298)

Minimum Information about a Biosynthetic Gene cluster [PDF]

Nature Chemical Biology, 2015
M.H.M. was supported by a Rubicon fellowship of the Netherlands Organization for Scientific Research (NWO;Rubicon 825.13.001). The work of R.K. was supported by the European Union’s Seventh Framework Programme(Joint Call OCEAN.2011–2: Marine microbial diversity—new insights into marine ecosystems functioning and its biotechnological potential) under ...
Medema, Marnix H, Kottmann, Renzo, Yilmaz, Yi, Cummings, Matthew, Biggins, John B, Blin, Kai, de Bruijn, Irene, Chooi, Yi, Claesen, Jan, Coates, R Cameron, Cruz-Morales, Pablo, Duddela, Srikanth, Düsterhus, Stephanie, Edwards, Daniel, Fewer, David P, Garg, Neha, Geiger, Christoph, Ju, Juan Pablo, Ju, Jianhua, Greule, Anja, Hadjithomas, Michalis, Haines, Anthony S, Helfrich, Eric J N, Hillwig, Matthew L, Ishida, Keishi, Jones, Jon, Ju, Katrin, Kegler, Carsten, Kim, Hyun Uk, Kötter, Peter, Krug, Daniel, Masschelein, Joleen, Melnik, Alexey V, Mantovani, Simone M, Monroe, Emily A, Moore, Marcus, Moss, Nathan, Nützmann, Hans-Wilhelm, Pan, Guohui, Pati, Amrita, Petras, Daniel, Reen, F Jerry, Rosconi, Federico, Rui, Zhe, Tian, Zhenhua, Tobias, Nicholas J, Yu, Yuta, Wiemann, Philipp, Wyckoff, Elizabeth, Yan, Xiaohui, Yim, Yi, Yu, Fengan, Xie, Yunchang, Aigle, Bertrand, Apel, Alexander K, Balibar, Carl J, Balskus, Emily P, Barona-Gómez, Francisco, Bechthold, Andreas, Bode, Helge B, Borriss, Rainer, Brady, Sean, Brakhage, Axel A, Caffrey, Patrick, Cheng, Yi, Clardy, Jon, Cox, Russell J, de Mot, René, Donadio, Stefano, Donia, Mohamed S, van Der Donk, Wilfred A, Dorrestein, Pieter C, Doyle, Sean, Driessen, Arnold J M, Ehling-Schulz, Monika, Entian, Karl-Dieter, Fischbach, Michael A, Gerwick, Lena, Gerwick, William H, Gross, Harald, Gust, Bertolt, Hertweck, Christian, Höfte, Monica, Jensen, Jens, Katz, Leonard, Kaysser, Leonard, Klassen, Jonathan L, Keller, Nancy P, Kormanec, Jan, Kuipers, Oscar P, Kuzuyama, Tomohisa, Kyrpides, Nikos C, Kwon, Hyung-Jin, Lautru, Sylvie, Lavigne, Rob, Lee, Chia y, Linquan, Bai, Liu, Xinyu, Liu, Wen, Luzhetskyy, Andriy, Mahmud, Taifo, Mast, Yi, Mast, Yvonne, Méndez, Carmen, Metsä-Ketelä, Mikko, Micklefield, Jason, Mitchell, Douglas A, Moore, Bradley S, Moreira, Leonilde M, Müller, Rolf, Neilan, Brett A, Nett, Markus, Nielsen, Jens, O'Gara, Fergal, Oikawa, Hideaki, Osbourn, Anne, Osburne, Marcia S, Ostash, Bohdan, Payne, Shelley M, Pernodet, Jean-Luc, Petricek, Miroslav, Piel, Jörn, Ploux, Olivier, Raaijmakers, Jos M, Salas, José A, Schmitt, Esther K, Scott, Barry, Seipke, Ryan F, Shen, Ben, Sherman, David H, Sivonen, Kaarina, Smanski, Michael J, Sosio, Margherita, Stegmann, Evi, Süssmuth, Roderich D, Tahlan, Kapil, Thomas, Christopher M, Tang, Yi, Truman, Andrew W, Viaud, Muriel, Walton, Jonathan D, Walsh, Christopher T, Weber, Tilmann, van Wezel, Gilles P, Wilkinson, Barrie, Willey, Joanne M, Wohlleben, Wolfgang, Wright, Gerard D, Ziemert, Nadine, Zhang, Changsheng, Zotchev, Sergey B, Breitling, Rainer, Takano, Eriko, Glöckner, Frank Oliver, Moore, Jon, Ju, Guohui, Ju, Xiaohui   +156 more
core   +24 more sources

Functional Analysis of the Fusarielin Biosynthetic Gene Cluster [PDF]

Molecules, 2016
Fusarielins are polyketides with a decalin core produced by various species of Aspergillus and Fusarium. Although the responsible gene cluster has been identified, the biosynthetic pathway remains to be elucidated.
Aida Droce, Wagma Saei, Simon Hartung Jørgensen, Reinhard Wimmer, Henriette Giese, Rasmus Dam Wollenberg, Teis Esben Sondergaard, Jens Laurids Sørensen   +7 more
doaj   +4 more sources

Heterologous expression of pikromycin biosynthetic gene cluster using Streptomyces artificial chromosome system

Microbial Cell Factories, 2017
Background Heterologous expression of biosynthetic gene clusters of natural microbial products has become an essential strategy for titer improvement and pathway engineering of various potentially-valuable natural products.
Hye-rim Pyeon, Hee-Ju Nah, Seung-Hoon Kang, Si-Sun Choi, Eung-Soo Kim   +4 more
doaj   +2 more sources

Characterization of the Actinonin Biosynthetic Gene Cluster

ChemBioChem, 2018
AbstractThe hydroxamate moiety of the natural product actinonin mediates inhibition of metalloproteinases because of its chelating properties towards divalent cations in the active site of those enzymes. Owing to its antimicrobial activity, actinonin has served as a lead compound for the development of new antibiotic drug candidates.
Felix Wolf, Franziska Leipoldt, Andreas Kulik, Daniel Wibberg, Jörn Kalinowski, Leonard Kaysser   +5 more
openaire   +3 more sources

Biosynthetic Gene Cluster of Linaridin Peptides Contains Epimerase Gene [PDF]

ChemBioChem, 2022
AbstractSalinipeptins belong to the type‐A linaridin class of ribosomally synthesized and post‐translationally modified peptides (RiPPs) comprising 22 amino acid residues with multiple D‐amino acids. Although chirality of other type‐A linaridins, such as grisemycin and cypemycin, has not been reported, the biosynthetic gene clusters of type‐A ...
Wanlu Xiao, Yasuharu Satoh, Yasushi Ogasawara, Tohru Dairi   +3 more
openaire   +4 more sources

Biosynthetic gene cluster for the cladoniamides, bis-indoles with a rearranged scaffold. [PDF]

PLoS ONE, 2011
The cladoniamides are bis-indole alkaloids isolated from Streptomyces uncialis, a lichen-associated actinomycete strain. The cladoniamides have an unusual, indenotryptoline structure rarely observed among bis-indole alkaloids. I report here the isolation,
Katherine S Ryan
doaj   +2 more sources

The Biosynthetic Gene Cluster of Boydines in Scedosporium apiospermum. [PDF]

Mycopathologia
Abstract Although Scedosporium species may cause severe infections in immunocompromised patients, little is known about their pathogenic mechanisms. The thioredoxin reductases (TrxRs) of Scedosporium apiospermum are thought to play an ...
Carvalho C, Hérivaux A, Wéry M, Jouhanneau JC, Papon N, Bouchara JP.   +5 more
europepmc   +3 more sources

Identification, heterologous expression, and characterization of the tolypodiol biosynthetic gene cluster through an integrated approach. [PDF]

, 2023
Cyanobacteria are tremendous producers of biologically active natural products including the potent anti-inflammatory compound tolypodiol. However, linking biosynthetic gene clusters with compound production in cyanobacteria has lagged behind other ...
Philip , Williams, Timothy J., O\u27Donnell, Kyle , Axt, Benjamin, Philmus, Daniel, Back, Juan , Vanegas, Joshua , Gurr   +6 more
core   +2 more sources

The Biosynthetic Gene Clusters of Aminocoumarin Antibiotics [PDF]

Planta Medica, 2006
Plants and microorganisms are the most important sources of secondary metabolites in nature. For research in the functional genomics of secondary metabolism, and for the biotechnological application of such research by genetic engineering and combinatorial biosynthesis, most microorganisms offer a unique advantage to the researcher: the biosynthetic ...
Shu-Ming, Li, Lutz, Heide
openaire   +2 more sources

Multiplexed mobilization and expression of biosynthetic gene clusters

Nature Communications, 2022
AbstractBacterial genomes contain large reservoirs of biosynthetic gene clusters (BGCs) that are predicted to encode unexplored natural products. Heterologous expression of previously unstudied BGCs should facilitate the discovery of additional therapeutically relevant bioactive molecules from bacterial culture collections, but the large-scale ...
Vincent Libis, Logan W. MacIntyre, Rabia Mehmood, Liliana Guerrero, Melinda A. Ternei, Niv Antonovsky, Ján Burian, Zongqiang Wang, Sean F. Brady   +8 more
openaire   +3 more sources