Results 21 to 30 of about 373,234 (333)

Identification and analysis of the paulomycin biosynthetic gene cluster and titer improvement of the paulomycins in Streptomyces paulus NRRL 8115. [PDF]

PLoS ONE, 2015
The paulomycins are a group of glycosylated compounds featuring a unique paulic acid moiety. To locate their biosynthetic gene clusters, the genomes of two paulomycin producers, Streptomyces paulus NRRL 8115 and Streptomyces sp. YN86, were sequenced. The
Jine Li, Zhoujie Xie, Min Wang, Guomin Ai, Yihua Chen   +4 more
doaj   +2 more sources

Biosynthetic gene cluster for the cladoniamides, bis-indoles with a rearranged scaffold. [PDF]

PLoS ONE, 2011
The cladoniamides are bis-indole alkaloids isolated from Streptomyces uncialis, a lichen-associated actinomycete strain. The cladoniamides have an unusual, indenotryptoline structure rarely observed among bis-indole alkaloids. I report here the isolation,
Katherine S Ryan
doaj   +2 more sources

Identification and heterologous expression of the globomycin biosynthetic gene cluster [PDF]

Synthetic and Systems Biotechnology, 2023
Globomycin is a cyclic lipodepsipeptide originally isolated from several Streptomyces species which displays strong and selective antibacterial activity against Gram-negative pathogens.
Weber, Tilmann, Sterndorff, Eva Baggesgaard, Martín, Jesús, Ortiz-López, Francisco Javier, Reyes, Fernando, Gren, Tetiana, Jørgensen, Tue S., Jiang, Xinglin, Oves-Costales, Daniel, Román-Hurtado, Fernando, Genilloud, Olga   +10 more
core   +4 more sources

Transcriptional regulation of the novobiocin biosynthetic gene cluster. [PDF]

Microbiology, 2009
International audienceThe aminocoumarin antibiotic novobiocin is a gyrase inhibitor formed by a Streptomyces strain. The biosynthetic gene cluster of novobiocin spans 23.4 kb and contains 20 coding sequences, among them the two regulatory genes novE and ...
Goerke, Christiane, J. Harle, Wolz, Christiane, Gust, Bertolt, V. Dangel, J.-L. Pernodet, Härle, Johannes, Heide, Lutz, Pernodet, Jean-Luc, L. Heide, C. Wolz, B. Gust, Dangel, Volker, C. Goerke   +13 more
core   +4 more sources

MIBiG 2.0: a repository for biosynthetic gene clusters of known function [PDF]

Nucleic Acids Res., 2019
Fueled by the explosion of (meta)genomic data, genome mining of specialized metabolites has become a major technology for drug discovery and studying microbiome ecology.
Tracanna, V., Selem-Mojica, N., Weber, T., Navarro-Muñoz, J. C., van Santen, J. A., Lund, G., Medema, M. H., Terlouw, B. R., Collemare, J., Shaw, S., Andreu, V. P., Sisto, A. C., Duran, H. G. S., Charkoudian, L. K., Robinson, S. L., Epstein, S. C., Kautsar, S. A., Blin, K., van der Hooft, J. J. J., Alanjary, M., Linington, R. G.   +20 more
core   +2 more sources

The Biosynthetic Gene Cluster of Boydines in Scedosporium apiospermum. [PDF]

Mycopathologia
Abstract Although Scedosporium species may cause severe infections in immunocompromised patients, little is known about their pathogenic mechanisms. The thioredoxin reductases (TrxRs) of Scedosporium apiospermum are thought to play an ...
Carvalho C, Hérivaux A, Wéry M, Jouhanneau JC, Papon N, Bouchara JP.   +5 more
europepmc   +3 more sources

Uncovering a miltiradiene biosynthetic gene cluster in the Lamiaceae reveals a dynamic evolutionary trajectory

Nature Communications, 2023
The spatial organization of genes within plant genomes can drive evolution of specialized metabolic pathways. Terpenoids are important specialized metabolites in plants with diverse adaptive functions that enable environmental interactions.
Abigail E. Bryson, E. Lanier, K. Lau, J. Hamilton, Brieanne Vaillancourt, Davis T. Mathieu, Alan E. Yocca, G. Miller, P. Edger, C. R. Buell, B. Hamberger   +10 more
semanticscholar   +1 more source

Biosynthetic gene cluster profiling predicts the positive association between antagonism and phylogeny in Bacillus

bioRxiv, 2021
Understanding the driving forces and intrinsic mechanisms of microbial competition is a fundamental question in microbial ecology. Despite the well-established negative correlation between exploitation competition and phylogenetic distance, the process ...
L. Xia, Youzhi Miao, A’li Cao, Yan Liu, Zihao Liu, Xinli Sun, Yansheng Xue, Zhihui Xu, Weibing Xun, Q. Shen, N. Zhang, Ruifu Zhang   +11 more
semanticscholar   +1 more source

Multiplexed mobilization and expression of biosynthetic gene clusters

Nature Communications, 2022
AbstractBacterial genomes contain large reservoirs of biosynthetic gene clusters (BGCs) that are predicted to encode unexplored natural products. Heterologous expression of previously unstudied BGCs should facilitate the discovery of additional therapeutically relevant bioactive molecules from bacterial culture collections, but the large-scale ...
Vincent Libis, Logan W. MacIntyre, Rabia Mehmood, Liliana Guerrero, Melinda A. Ternei, Niv Antonovsky, Ján Burian, Zongqiang Wang, Sean F. Brady   +8 more
openaire   +3 more sources

The Biosynthetic Gene Clusters of Aminocoumarin Antibiotics [PDF]

Planta Medica, 2006
Plants and microorganisms are the most important sources of secondary metabolites in nature. For research in the functional genomics of secondary metabolism, and for the biotechnological application of such research by genetic engineering and combinatorial biosynthesis, most microorganisms offer a unique advantage to the researcher: the biosynthetic ...
Shu-Ming, Li, Lutz, Heide
openaire   +2 more sources