Results 21 to 30 of about 3,674,475 (302)
Marine Drugs, 2018 The biosynthetic gene cluster for bisucaberin B (1, bsb gene cluster), an N-hydroxy-N-succinyl diamine (HSD)-based siderophore, was cloned from the marine bacterium Tenacibaculum mesophilum, originated from a marine sponge.
Masaki J. Fujita +2 more
doaj +1 more source
mBio, 2020 Advances in genome sequencing have revitalized natural product discovery efforts, revealing the untapped biosynthetic potential of fungi. While the volume of genomic data continues to expand, discovery efforts are slowed due to the time-consuming nature ...
Lindsay K. Caesar +11 more
doaj +1 more source
Identification and analysis of the paulomycin biosynthetic gene cluster and titer improvement of the paulomycins in Streptomyces paulus NRRL 8115. [PDF]
PLoS ONE, 2015 The paulomycins are a group of glycosylated compounds featuring a unique paulic acid moiety. To locate their biosynthetic gene clusters, the genomes of two paulomycin producers, Streptomyces paulus NRRL 8115 and Streptomyces sp. YN86, were sequenced. The
Jine Li +4 more
doaj +1 more source
Isolation and characterization of the gibberellin biosynthetic gene cluster in Sphaceloma manihoticola [PDF]
, 2008 Gibberellins (GAs) are tetracyclic diterpenoid phytohormones that were first identified as secondary metabolites of the fungus Fusarium fujikuroi (teleomorph, Gibberella fujikuroi). GAs were also found in the cassava pathogen Sphaceloma manihoticola, but
Hedden, P. +9 more
core +1 more source
Characterization of the Ergosterol Biosynthesis Pathway in Ceratocystidaceae
Journal of Fungi, 2021 Terpenes represent the biggest group of natural compounds on earth. This large class of organic hydrocarbons is distributed among all cellular organisms, including fungi.
Mohammad Sayari +5 more
doaj +1 more source
In silico analyses of maleidride biosynthetic gene clusters [PDF]
Fungal Biology and Biotechnology, 2021 Abstract Maleidrides are a family of structurally related fungal natural products, many of which possess diverse, potent bioactivities. Previous identification of several maleidride biosynthetic gene clusters, and subsequent experimental work, has determined the ‘core’ set of genes required to construct the ...
Katherine Williams +3 more
openaire +6 more sources
Acta Pharmaceutica Sinica B, 2018 Fungal genomes carry many gene clusters seemingly capable of natural products biosynthesis, yet most clusters remain cryptic or down-regulated. Genome mining revealed an unconventional paraherquonin-like meroterpenoid biosynthetic gene cluster in the ...
Tao Zhang +5 more
doaj +1 more source
Biosynthetic gene cluster for the cladoniamides, bis-indoles with a rearranged scaffold. [PDF]
PLoS ONE, 2011 The cladoniamides are bis-indole alkaloids isolated from Streptomyces uncialis, a lichen-associated actinomycete strain. The cladoniamides have an unusual, indenotryptoline structure rarely observed among bis-indole alkaloids. I report here the isolation,
Katherine S Ryan
doaj +1 more source
Mining biosynthetic gene clusters in Virgibacillus genomes [PDF]
BMC Genomics, 2019 Biosynthetic gene clusters produce a wide range of metabolites with activities that are of interest to the pharmaceutical industry. Specific interest is shown towards those metabolites that exhibit antimicrobial activities against multidrug-resistant bacteria that have become a global health threat.
Ghofran Othoum +8 more
openaire +6 more sources
Microorganisms, 2021 The strain Streptomyces cacaoi CA-170360 produces the cyclic pentapeptides pentaminomycins A–H and BE-18257 A–C, two families of cyclopeptides synthesized by two non-ribosomal peptide synthetases encoded in tandem within the same biosynthetic gene ...
Fernando Román-Hurtado +6 more
doaj +1 more source