Results 51 to 60 of about 373,234 (333)

Biosynthetic gene clusters and the evolution of fungal chemodiversity

Natural Product Reports, 2020
This highlight synthesizes knowledge of the molecular evolutionary processes – functional divergence, horizontal transfer, andde novoassembly – that govern biosynthetic gene cluster diversification and the generation of chemodiversity in fungi.
Antonis Rokas, Matthew E. Mead, Jacob L. Steenwyk, Huzefa A. Raja, Nicholas H. Oberlies   +4 more
openaire   +3 more sources

The biosynthetic pathway to tetromadurin (SF2487/A80577), a polyether tetronate antibiotic.

PLoS ONE, 2020
The type I polyketide SF2487/A80577 (herein referred to as tetromadurin) is a polyether tetronate ionophore antibiotic produced by the terrestrial Gram-positive bacterium Actinomadura verrucosospora.
Rory F Little, Markiyan Samborskyy, Peter F Leadlay   +2 more
doaj   +2 more sources

Identification of a Novel Biosynthetic Gene Cluster in Aspergillus niger Using Comparative Genomics

Journal of Fungi, 2021
Previously, DNA microarrays analysis showed that, in co-culture with Bacillus subtilis, a biosynthetic gene cluster anchored with a nonribosomal peptides synthetase of Aspergillus niger is downregulated.
Gregory Evdokias, Cameron Semper, Montserrat Mora-Ochomogo, Marcos Di Falco, Thi Truc Minh Nguyen, Alexei Savchenko, Adrian Tsang, Isabelle Benoit-Gelber   +7 more
doaj   +1 more source

The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin. [PDF]

Proceedings of the National Academy of Sciences, 1995
The macrocyclic polyketides rapamycin and FK506 are potent immunosuppressants that prevent T-cell proliferation through specific binding to intracellular protein receptors (immunophilins). The cloning and specific alteration of the biosynthetic genes for these polyketides might allow the biosynthesis of clinically valuable analogues.
Schwecke, Torsten, Aparicio, Jesús F., Molnár, István, König, Ariane, Khaw, Lake Ee, Haydock, Stephen F., Oliynyk, Markiyan, Caffrey, Patrick, Cortés, Jesús, Lester, John B., Böhm, Günter A., Staunton, James, Leadlay, Peter F.   +12 more
openaire   +2 more sources

The insect pathogen Serratia marcescens Db10 uses a hybrid non-ribosomal peptide synthetase-polyketide synthase to produce the antibiotic althiomycin [PDF]

, 2012
There is a continuing need to discover new bioactive natural products, such as antibiotics, in genetically-amenable micro-organisms. We observed that the enteric insect pathogen, Serratia marcescens Db10, produced a diffusible compound that inhibited the
Coulthurst Sarah J., Challis Gregory L., Stanley-Wall, Nicola R; id_orcid, Gregory L Challis, Gerc, Amy J., Amy J. Gerc, Gerc Amy J., Nicola R Stanley-Wall, Gregory L. Challis (136140), Song Lijiang, Coulthurst, Sarah J; id_orcid, Sarah J. Coulthurst, Lijiang Song (136135), Lijiang Song, Stanley-Wall, Nicola R., Stanley-Wall Nicola R., Coulthurst, Sarah J., Nicola R. Stanley-wall, Challis, Gregory L., Challis, Gregory L, Amy J Gerc, Sarah J. Coulthurst (136148), Song, Lijiang, Gerc, Amy J, Amy J. Gerc, Amy J. Gerc (136131), Nicola R. Stanley-Wall (136144), Sarah J Coulthurst, Gregory L. Challis   +28 more
core   +1 more source

Cyclofaulknamycin with the Rare Amino Acid D-capreomycidine Isolated from a Well-Characterized Streptomyces albus Strain

Microorganisms, 2021
Targeted genome mining is an efficient method of biosynthetic gene cluster prioritization within constantly growing genome databases. Using two capreomycidine biosynthesis genes, alpha-ketoglutarate-dependent arginine beta-hydroxylase and pyridoxal ...
Liliya Horbal, Marc Stierhof, Anja Palusczak, Nikolas Eckert, Josef Zapp, Andriy Luzhetskyy   +5 more
doaj   +1 more source

A Single Biosynthetic Gene Cluster Is Responsible for the Production of Bagremycin Antibiotics and Ferroverdin Iron Chelators

mBio, 2019
Access to whole-genome sequences has exposed the general incidence of the so-called cryptic biosynthetic gene clusters (BGCs), thereby renewing their interest for natural product discovery.
L. Martinet, Aymeric Naômé, Benoit Deflandre, Marta Maciejewska, Déborah Tellatin, Elodie Tenconi, Nicolas Smargiasso, E. De Pauw, G. V. van Wezel, S. Rigali   +9 more
semanticscholar   +1 more source

Direct Pathway Cloning Combined with Sequence- and Ligation-Independent Cloning for Fast Biosynthetic Gene Cluster Refactoring and Heterologous Expression.

ACS Synthetic Biology, 2018
The need  for new pharmacological lead structures, especially against drug resistances, has led to a surge in natural product research and discovery. New biosynthetic gene cluster capturing methods to efficiently clone and heterologously express natural ...
P. D’Agostino, T. Gulder
semanticscholar   +1 more source

Characterization of the depsidone gene cluster reveals etherification, decarboxylation and multiple halogenations as tailoring steps in depsidone assembly

Acta Pharmaceutica Sinica B, 2023
Depsides and depsidones have attracted attention for biosynthetic studies due to their broad biological activities and structural diversity. Previous structure‒activity relationships indicated that triple halogenated depsidones display the best anti ...
Jiafan Yang, Zhenbin Zhou, Yingying Chen, Yongxiang Song, Jianhua Ju   +4 more
doaj   +1 more source

CAGECAT: The CompArative GEne Cluster Analysis Toolbox for rapid search and visualisation of homologous gene clusters

bioRxiv, 2023
Background Co-localized sets of genes that encode specialized functions are common across microbial genomes and occur in genomes of larger eukaryotes as well.
Matthias van den Belt, Cameron L. M. Gilchrist, Thomas J. Booth, Y. Chooi, M. Medema, Mohammad Alanjary   +5 more
semanticscholar   +1 more source