Results 51 to 60 of about 3,674,475 (302)

Cloning and characterization of the biosynthetic gene cluster for kutznerides [PDF]

Proceedings of the National Academy of Sciences, 2007
Kutznerides, actinomycete-derived cyclic depsipetides, consist of six nonproteinogenic residues, including a highly oxygenated tricyclic hexahydropyrroloindole, a chlorinated piperazic acid, 2-(1-methylcyclopropyl)-glycine, a β-branched-hydroxy acid, and 3-hydroxy glutamic acid, for which biosynthetic logic has not been elucidated.
Danica Galonic, Fujimori, Sinisa, Hrvatin, Christopher S, Neumann, Matthias, Strieker, Mohamed A, Marahiel, Christopher T, Walsh   +5 more
openaire   +2 more sources

Marine Microbial-Derived Resource Exploration: Uncovering the Hidden Potential of Marine Carotenoids

Marine Drugs, 2022
Microbes in marine ecosystems are known to produce secondary metabolites. One of which are carotenoids, which have numerous industrial applications, hence their demand will continue to grow.
Ray Steven, Zalfa Humaira, Yosua Natanael, Fenny M. Dwivany, Joko P. Trinugroho, Ari Dwijayanti, Tati Kristianti, Trina Ekawati Tallei, Talha Bin Emran, Heewon Jeon, Fahad A. Alhumaydhi, Ocky Karna Radjasa, Bonglee Kim   +12 more
doaj   +1 more source

The erythromycin biosynthetic gene cluster of Aeromicrobium erythreum

Journal of Industrial Microbiology & Biotechnology, 2004
The erythromycin-biosynthetic (ery) gene cluster of Aeromicrobium erythreum was cloned and characterized. The 55.4-kb cluster contains 25 ery genes. Homologues were found for each gene in the previously characterized ery gene cluster from Saccharopolyspora erythraea. In addition, four new predicted ery genes were identified.
Igor A, Brikun, Andrew R, Reeves, William H, Cernota, Minh B, Luu, J Mark, Weber   +4 more
openaire   +2 more sources

Biosynthetic gene clusters and the evolution of fungal chemodiversity

Natural Product Reports, 2020
This highlight synthesizes knowledge of the molecular evolutionary processes – functional divergence, horizontal transfer, and de novo assembly – that govern biosynthetic gene cluster diversification and the generation of chemodiversity in fungi.
Antonis Rokas, Matthew E. Mead, Jacob L. Steenwyk, Huzefa A. Raja, Nicholas H. Oberlies   +4 more
openaire   +3 more sources

Kanamycin biosynthetic gene cluster and proposed kanamycin biosynthetic pathways.

, 2018
(a) Kanamycin biosynthetic gene cluster. (b) Proposed parallel and linear kanamycin biosynthetic pathways.
Zheng Wu (344022), Huanzhang Xia (561060), Xianpu Ni (3491882), Junyang Sun (4285090), Wenli Gao (245749)   +4 more
core   +1 more source

Chromatin-level regulation of biosynthetic gene clusters [PDF]

Nature Chemical Biology, 2009
Loss-of-function Aspergillus nidulans CclA, a Bre2 ortholog involved in histone H3 lysine 4 methylation, activated the expression of cryptic secondary metabolite clusters in A. nidulans. One new cluster generated monodictyphenone, emodin and emodin derivatives, whereas a second encoded two anti-osteoporosis polyketides, F9775A and F9775B.
Jin Woo, Bok, Yi-Ming, Chiang, Edyta, Szewczyk, Yazmid, Reyes-Dominguez, Ashley D, Davidson, James F, Sanchez, Hsien-Chun, Lo, Kenji, Watanabe, Joseph, Strauss, Berl R, Oakley, Clay C C, Wang, Nancy P, Keller   +11 more
openaire   +2 more sources

MIBiG 3.0: a community-driven effort to annotate experimentally validated biosynthetic gene clusters [PDF]

, 2023
With an ever-increasing amount of (meta)genomic data being deposited in sequence databases,(meta)genome mining for natural product biosynthetic pathways occupies a critical role in the discovery of novel pharmaceutical drugs, crop protection agents and ...
Aguilar, C., Vromans, S. P. J. M., Gayrard, D., Lin, G., Lund, G., Medema, M. H., Louwen, J. J. R., Li, Y., Al-Salihi, S. A. A., Pronk, L. J. U., Robinson, S., Winter, J. M., Avelar-Rivas, J. A., Navarro-Munoz, J. C., Rego, A., Hooft, J. J. V. D., Chagas, F. O., Sing, K. S., Chevrette, M. G., Kang, K. B., Linington, R. G., Louwen, N. L., Philmus, B., Parra, J., Witte, T. E., Zaroubi, L., Aleti, G., Augustijn, H. E., Collemare, J., Lee, W-S., Kautsar, S., Zdouc, M., Torring, T., Yu, J., Bernaldo-Aguero, J., Helfrich, E. J. N., Zhong, Z., Pourmohsenin, B., Reitz, Z. L., Blin, K., Barona-Gomez, F., Cruz-Morales, P., Kalkreuter, E., Selem-Mojica, N., Rex, D. A. B., Weber, T., Kunjapur, A. M., Tang, X., Biermann, F., Terlouw, B. R., Booth, T. J., Yang, H. X. D., Duncan, K. R., Loureiro, C., Vigneshwari, A., Udwary, D., Avalon, N. E., Waschulin, V., Bielinski, V. A., Sokolova, N., Rosas-Becerra, L. R., Haslinger, K., Vind, K., Meijer, D., Gutierrez-Garcıa, K., Avitia-Domınguez, L. A., Bravo, V. J. C., Egbert, S., Williams, S. E., Roxborough, E. T., Schorn, M. A., Kim, W., Gavriilidou, A., Jati, A. P., Castelo-Branco, R., Kalyvas, N., Scobie, D. J., Alanjary, M., Santen, J. A. V., Du, C., Recchia, M. J. J.   +80 more
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The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin. [PDF]

Proceedings of the National Academy of Sciences, 1995
The macrocyclic polyketides rapamycin and FK506 are potent immunosuppressants that prevent T-cell proliferation through specific binding to intracellular protein receptors (immunophilins). The cloning and specific alteration of the biosynthetic genes for these polyketides might allow the biosynthesis of clinically valuable analogues.
Schwecke, Torsten, Aparicio, Jesús F., Molnár, István, König, Ariane, Khaw, Lake Ee, Haydock, Stephen F., Oliynyk, Markiyan, Caffrey, Patrick, Cortés, Jesús, Lester, John B., Böhm, Günter A., Staunton, James, Leadlay, Peter F.   +12 more
openaire   +2 more sources

The insect pathogen Serratia marcescens Db10 uses a hybrid non-ribosomal peptide synthetase-polyketide synthase to produce the antibiotic althiomycin [PDF]

, 2012
There is a continuing need to discover new bioactive natural products, such as antibiotics, in genetically-amenable micro-organisms. We observed that the enteric insect pathogen, Serratia marcescens Db10, produced a diffusible compound that inhibited the
Coulthurst Sarah J., Challis Gregory L., Stanley-Wall, Nicola R; id_orcid, Gregory L Challis, Gerc, Amy J., Amy J. Gerc, Gerc Amy J., Nicola R Stanley-Wall, Gregory L. Challis (136140), Song Lijiang, Coulthurst, Sarah J; id_orcid, Sarah J. Coulthurst, Lijiang Song (136135), Lijiang Song, Stanley-Wall, Nicola R., Stanley-Wall Nicola R., Coulthurst, Sarah J., Nicola R. Stanley-wall, Challis, Gregory L., Challis, Gregory L, Amy J Gerc, Sarah J. Coulthurst (136148), Song, Lijiang, Gerc, Amy J, Amy J. Gerc, Amy J. Gerc (136131), Nicola R. Stanley-Wall (136144), Sarah J Coulthurst, Gregory L. Challis   +28 more
core   +2 more sources

Transcriptional regulation of the novobiocin biosynthetic gene cluster [PDF]

Microbiology, 2009
The aminocoumarin antibiotic novobiocin is a gyrase inhibitor formed by a Streptomyces strain. The biosynthetic gene cluster of novobiocin spans 23.4 kb and contains 20 coding sequences, among them the two regulatory genes novE and novG. We investigated the location of transcriptional promoters within this cluster by insertion of transcriptional ...
Dangel, Volker, Härle, Johannes, Goerke, Christiane, Wolz, Christiane, Gust, Bertolt, Pernodet, Jean-Luc, Heide, Lutz   +6 more
openaire   +3 more sources