Results 51 to 60 of about 3,454,458 (298)
MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration [PDF]
Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in agriculture, engineering and medicine.Aguilar, C., Donahey, M. S. C., Teufel, R., Medema, M. H., Huynh, T., Jing, J., Katsuyama, Y., Zimmermann, C., Mahmud, T., Jayachandran, S., Streiff, A. B., Hooft, J. J. V. D., Barbieri, H. B., Macias, M. I., Liu, J., Santos-Medellin, C., Linington, R. G., Parra, J., Witte, T. E., Aleti, G., Augustijn, H. E., Barbosa, J. C. J., Koetsier, R. A., Borriss, R., Bulcock, B. W., Ryu, B., Bernaldo-Aguero, J., Creamer, K. E., Ostash, B. O., Tarnowski, M. J., Rubio, M. P., Kim, G. J., Hanif, N., Grayson, N. E., Bozhuyuk, K. A., Hindra, H., Kalkreuter, E., Kim, H., Rutz, A., Kakumu, Y., Li, S., Carrion, V. J., Choi, H., Barra, L., Larsen, N. J., Pham, H. T., Duncan, K. R., Damiani, T., Krug, D., Navarro, J., Robinson, S. L., Bhatt, K. M., Saldanha, M., Rosas-Becerra, L. R., Kollten, C., Gutierrez-Garcia, K., Haslinger, K., Ramesh, S., Singh, G., Connolly, J. A., Rojo, M. Y. A., Otani, H., Cumsille, A., Warnasinghe, R., Williams, S. E., Hoing, L., Korenskaia, A., Licona-Cassani, C., Merrild, A., Le, N., Singh, H., Kubach, N., Cano-Prieto, C., Rey, T., Kust, A., Reher, R., Zimmer, L., Gu, W., Strüder, A., Tan, B., Sowa, S. T., Truman, A. W., Doering, D. T., Chromy, J., Parade, D. S., Rosiles, P. Y., Salvi, L., Borges, R. M., Charria-Giron, E., Kang, K. B., Jenner, M., Sieber, S., Fewer, D. P., Tugizimana, F., Guerra, S., Machushynets, N. V., Torring, T., Yu, J., Paliya, S., Cediel-Becerra, J. D., Shah, A. D., Park, J., Lopez, J. A. V., Libis, V., Müller, A. V., Weber, T., Nguyen, G., Yang, D., Castro-Falcon, G., Dillen, J., Jung, J. J., Schoellhorn, S. M., Szenei, J., Ulbricht, C., Durusu, S., Singh, K. S., Yamada, K., Trindade, M., Frediansyah, A., Bielinski, V. A., Sokolova, N., Niedermeyer, T. H. J., Pan, X., Lorio, M., Flores, S. G., Weddeling, H. G., Hart, L., Surup, F., Cruz, A. A., Selem, N., Lee, B. T., Ossowicki, A., Kushnareva, A. K., Morgan, K. D., Kriukova, Y., Barrett, S. E., Kim, W., Gurevich, A., Rasmussen, M. H., Gavriilidou, A., Beemelmanns, C., Holland, D. C., Chooi, Y. H., Steffen, K., Sala, G. D., Foldi, J., Carter, R. S., Beqaj, D., Klapper, M., Wezel, G. P. V., Zdouc, M. M., Al-Salihi, S. A., Phan, C., Li, Y., Dallery, J., Launay, A. P., Owen, C., Winter, J. M., Schumm, C., Avelar-Rivas, J. A., Kruijff, M. D., Dommaraju, S. R., McBride, C. M., Chagas, F. O., Metsä-Ketela, M., Alharthi, S. A., Mantri, S., Alberti, F., Philmus, B., Hu, J., Helfrich, E. J., Bretscher, K. M., Fetter, A., Pidot, S. J., Gonzalez-Salazar, L. A., Piel, J., Lev, K. L., Bailey, C. B., Reitz, Z. L., Brigham, M. W., Blin, K., Larralde, M., McLellan, R. M., Arishi, A. A., Feuermann, M., Crusemann, M., Romero-Otero, A., Maleckis, M., Lien, A., Hrab, P., Booth, T. J., Jeong, E., Loureiro, C., Hemmann, J. L., Sonnenschein, E. C., Greco, C., Mast, Y., Biermann1, F., Berger, T., Buedenbender, L., Shishido, T. K., Lamber, J., Padva, L., Panghal, M., Damas-Ramos, L. C., Martin, B. D., Terlouw1, B. R., D’Agostino, P. M., Gomez-Escribano, J. P., Gentile, A., Mitchell, D. A., Williams, K., Breitenbach, M., Castelo-Branco, R., Capela, J., Kang, S., Rocca, S. M. W., Faussurier, B., Bader, C. D., Stegmann, E., Segato, L. G. B., Kovacs, A. T., Ortega, L. R. T., Lund, G., Bettenbuhl, S. M., Udwary, D. W., Axt, K. K., Martinez-Martinez, A. M., Hebra, T., Rice, A. J., Baunach, M., Sahadeo, L., Rond, T. D., Gomez, J. E. G., Tagirdzhanov, A., Sbaraini, N., Chaudhry, V., Rego, A., Sánchez-Carvajal, E., Chevrette, M. G., Maximo, M. F., Zhou, Z., Holme, J. E., Ulanova, D., Louwen, N. L., Charlop-Powers, Z., Walmsley, M., Collemare, J., Choi, Y., Gerke, J., Pourmohsenin, B., Ellerhorst, M., Gerstmans, H., Svenningsen, T., Sehnal, L., Horch, T., He, B., Rigolet, A., Kunjapur, A. M., O’Hare, J. H., Weir, A. N., Silviani, V., Choupannejad, R., Melkonian, C., Sosio, M., Tvilum, M., Vader, L., Akiyama, D. Y., Garza, E. A., Zimmermann, A., Avalon, N. E., Tong, Y., Rakhmanov, M., Kim, H. U., Ziemert, N., Lacovelli, R., Thome, N. U., Nguyen, H. T., Lftime, D., Egbert, S., Chaudhri, A. A., Pup, E. D., Lebeer, S., Lee, K., Sweeney, D., Alanjary, M., Hwang, J. +286 morecore +1 more sourceChromatin-level regulation of biosynthetic gene clusters [PDF]
Nature Chemical Biology, 2009 Loss-of-function Aspergillus nidulans CclA, a Bre2 ortholog involved in histone H3 lysine 4 methylation, activated the expression of cryptic secondary metabolite clusters in A. nidulans. One new cluster generated monodictyphenone, emodin and emodin derivatives, whereas a second encoded two anti-osteoporosis polyketides, F9775A and F9775B.Jin Woo, Bok, Yi-Ming, Chiang, Edyta, Szewczyk, Yazmid, Reyes-Dominguez, Ashley D, Davidson, James F, Sanchez, Hsien-Chun, Lo, Kenji, Watanabe, Joseph, Strauss, Berl R, Oakley, Clay C C, Wang, Nancy P, Keller +11 moreopenaire +2 more sourcesThe biosynthetic gene cluster for the polyketide immunosuppressant rapamycin. [PDF]
Proceedings of the National Academy of Sciences, 1995 The macrocyclic polyketides rapamycin and FK506 are potent immunosuppressants that prevent T-cell proliferation through specific binding to intracellular protein receptors (immunophilins). The cloning and specific alteration of the biosynthetic genes for these polyketides might allow the biosynthesis of clinically valuable analogues.Schwecke, Torsten, Aparicio, Jesús F., Molnár, István, König, Ariane, Khaw, Lake Ee, Haydock, Stephen F., Oliynyk, Markiyan, Caffrey, Patrick, Cortés, Jesús, Lester, John B., Böhm, Günter A., Staunton, James, Leadlay, Peter F. +12 moreopenaire +2 more sourcesMIBiG 3.0: a community-driven effort to annotate experimentally validated biosynthetic gene clusters [PDF]
, 2023 With an ever-increasing amount of (meta)genomic data being deposited in sequence databases,(meta)genome mining for natural product biosynthetic pathways occupies a critical role in the discovery of novel pharmaceutical drugs, crop protection agents and ...Aguilar, C., Vromans, S. P. J. M., Gayrard, D., Lin, G., Lund, G., Medema, M. H., Louwen, J. J. R., Li, Y., Al-Salihi, S. A. A., Pronk, L. J. U., Robinson, S., Winter, J. M., Avelar-Rivas, J. A., Navarro-Munoz, J. C., Rego, A., Hooft, J. J. V. D., Chagas, F. O., Sing, K. S., Chevrette, M. G., Kang, K. B., Linington, R. G., Louwen, N. L., Philmus, B., Parra, J., Witte, T. E., Zaroubi, L., Aleti, G., Augustijn, H. E., Collemare, J., Lee, W-S., Kautsar, S., Zdouc, M., Torring, T., Yu, J., Bernaldo-Aguero, J., Helfrich, E. J. N., Zhong, Z., Pourmohsenin, B., Reitz, Z. L., Blin, K., Barona-Gomez, F., Cruz-Morales, P., Kalkreuter, E., Selem-Mojica, N., Rex, D. A. B., Weber, T., Kunjapur, A. M., Tang, X., Biermann, F., Terlouw, B. R., Booth, T. J., Yang, H. X. D., Duncan, K. R., Loureiro, C., Vigneshwari, A., Udwary, D., Avalon, N. E., Waschulin, V., Bielinski, V. A., Sokolova, N., Rosas-Becerra, L. R., Haslinger, K., Vind, K., Meijer, D., Gutierrez-Garcıa, K., Avitia-Domınguez, L. A., Bravo, V. J. C., Egbert, S., Williams, S. E., Roxborough, E. T., Schorn, M. A., Kim, W., Gavriilidou, A., Jati, A. P., Castelo-Branco, R., Kalyvas, N., Scobie, D. J., Alanjary, M., Santen, J. A. V., Du, C., Recchia, M. J. J. +80 morecore +1 more sourceTranscriptional regulation of the novobiocin biosynthetic gene cluster [PDF]
Microbiology, 2009 The aminocoumarin antibiotic novobiocin is a gyrase inhibitor formed by a Streptomyces strain. The biosynthetic gene cluster of novobiocin spans 23.4 kb and contains 20 coding sequences, among them the two regulatory genes novE and novG. We investigated the location of transcriptional promoters within this cluster by insertion of transcriptional ...Dangel, Volker, Härle, Johannes, Goerke, Christiane, Wolz, Christiane, Gust, Bertolt, Pernodet, Jean-Luc, Heide, Lutz +6 moreopenaire +3 more sourcesExploratory and Inferential Analysis of Gene Cluster Neighborhood Graphs [PDF]
, 2009 Many different cluster methods are frequently used in gene expression
data analysis to find groups of co–expressed genes. However, cluster algorithms with the
ability to visualize the resulting clusters are usually preferred.Voglhuber Ingo, Scharl Theresa, Leisch, Friedrich, Theresa Scharl, Leisch Friedrich, Friedrich Leisch, Voglhuber, Ingo, Ingo Voglhuber, Scharl, Theresa +8 morecore +1 more sourceThe human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt +4 morewiley +1 more sourceControl of Aflatoxin Production of Aspergillus flavus and Aspergillus
parasiticus Using RNA Silencing Technology by Targeting aflD (nor-1) Gene. [PDF]
, 2011 Aspergillus flavus and Aspergillus parasiticus are important pathogens of cotton,
corn, peanuts and other oil-seed crops, producing toxins both in the field and
during storage.Daniel Caley, Naresh Magan, Abdel-Hadi, A, Abdel-Hadi, Ahmed, Caley, D. P., Carter, D. R., Ahmed M. Abdel-Hadi, Ahmed Abdel-Hadi, David R. F. Carter, Caley, D, Carter, D, Daniel P. Caley, Magan, Naresh, David Carter, Magan, N +14 morecore +1 more source
