Results 1 to 10 of about 99,198 (289)

Activating cryptic biosynthetic gene clusters via ACTIMOT [PDF]

Engineering Microbiology
The mainstream strategy of genome mining relies on the homologous activation and heterologous expression of target biosynthetic gene clusters (BGCs).
Xiaoying Bian
doaj   +3 more sources

Biosynthetic Gene Clusters from Swine Gut Microbiome

Microorganisms, 2023
The abuse of antibiotics has become a serious health challenge in the veterinary field. It creates environmental selection pressure on bacteria and facilitates the rapid spread of antibiotic resistance genes.
Leli Wang, Yiru Zhang, Juan Xu, Chuni Wang, Lanmei Yin, Qiang Tu, Huansheng Yang, Jia Yin   +7 more
doaj   +3 more sources

In silico analyses of maleidride biosynthetic gene clusters [PDF]

Fungal Biology and Biotechnology, 2022
Maleidrides are a family of structurally related fungal natural products, many of which possess diverse, potent bioactivities. Previous identification of several maleidride biosynthetic gene clusters, and subsequent experimental work, has determined the ‘
Katherine Williams, Kate M. J. de Mattos-Shipley, Christine L. Willis, Andrew M. Bailey   +3 more
doaj   +6 more sources

Establishing conserved biosynthetic gene clusters of the phylum Myxococcota [PDF]

Applied and Environmental Microbiology
A surge in sequenced myxobacteria catalyzed by advancements in long-read genome and metagenome sequencing has provided sufficient data to scrutinize the conserved biosynthetic gene clusters (BGCs) within the phylum Myxococcota.
Shailaja Khanal Pokharel, Nawal Shehata, Andrew Ahearne, Thomas Knehans, Constance B. Bailey, Paul D. Boudreau, D. Cole Stevens   +6 more
doaj   +2 more sources

Bioinformatic exploration of RiPP biosynthetic gene clusters in lichens [PDF]

Fungal Biology and Biotechnology
Background Ribosomally synthesized and posttranslationally modified peptides (RiPPs) represent a relatively recent addition to the biosynthetic gene cluster (BGC) repertoire of fungi.
Anna Pasinato, Garima Singh
doaj   +2 more sources

Nisin-like biosynthetic gene clusters are widely distributed across microbiomes [PDF]

mBio
Bacteriocins are antimicrobial peptides/proteins that can have narrow or broad inhibitory spectra and remarkable potency against clinically relevant pathogens.
David Hourigan, Des Field, Ellen Murray, Ivan Sugrue, Paula M. O’Connor, Colin Hill, R. Paul Ross   +6 more
doaj   +2 more sources

Biosynthetic Potential of Hypogymnia Holobionts: Insights into Secondary Metabolite Pathways

Journal of Fungi, 2023
Lichens are symbiotic associations consisting of a photobiont (algae or cyanobacteria) and a mycobiont (fungus). They are known to produce a variety of unique secondary metabolites. To access this biosynthetic potential for biotechnological applications,
Nadim Ahmad, Manfred Ritz, Anjuli Calchera, Jürgen Otte, Imke Schmitt, Thomas Brueck, Norbert Mehlmer   +6 more
doaj   +1 more source

Biosynthetic gene cluster synteny: Orthologous polyketide synthases in Hypogymnia physodes, Hypogymnia tubulosa, and Parmelia sulcata

MicrobiologyOpen, 2023
Lichens are symbiotic associations consisting of a photobiont (algae or cyanobacteria) and a mycobiont (fungus), which together generate a variety of unique secondary metabolites.
Nadim Ahmad, Manfred Ritz, Anjuli Calchera, Jürgen Otte, Imke Schmitt, Thomas Brueck, Norbert Mehlmer   +6 more
doaj   +1 more source

The ubiquitous catechol moiety elicits siderophore and angucycline production in Streptomyces

Communications Chemistry, 2022
The biosynthetic gene clusters of Actinobacteria are poorly expressed in the laboratory, necessitating a better understanding of the signals that promote their expression in order to exploit their full biosynthetic potential.
Doris A. van Bergeijk, Somayah S. Elsayed, Chao Du, Isabel Nuñez Santiago, Anna M. Roseboom, Le Zhang, Victor J. Carrión, Herman P. Spaink, Gilles P. van Wezel   +8 more
doaj   +1 more source

Strain prioritization and genome mining for enediyne natural products [PDF]

, 2016
The enediyne family of natural products has had a profound impact on modern chemistry, biology, and medicine, and yet only 11 enediynes have been structurally characterized to date.
Ben Shen, Christoph Rader, Dong Yang, Filip Van Nieuwerburgh, Hindra, Huiming Ge, Ivana Crnovčičć, Jeffrey D. Rudolf, Jeremy R. Lohman, Li-Xing Zhao, Qihui Teng, Tingting Huang, Xiangcheng Zhu, Xiaohui Yan, Xiuling Li, Yannick Gansemans, Yanwen Duan, Yi Jiang, Yong Huang   +18 more
core   +6 more sources