Results 1 to 10 of about 356,235 (196)

Genome mining reveals novel biosynthetic gene clusters in entomopathogenic bacteria

Scientific Reports, 2023
The discovery of novel bioactive compounds produced by microorganisms holds significant potential for the development of therapeutics and agrochemicals.
Wipanee Meesil, Paramaporn Muangpat, Sutthirat Sitthisak, Triwit Rattanarojpong, Narisara Chantratita, Ricardo A. R. Machado, Yi-Ming Shi, Helge B. Bode, Apichat Vitta, Aunchalee Thanwisai   +9 more
doaj   +2 more sources

Multiplexed mobilization and expression of biosynthetic gene clusters

Nature Communications, 2022
Efficient mobilization and expression of biosynthetic gene clusters (BGCs) into heterologous hosts is needed for microbial natural products discovery. Here, the authors improve the CONKAT-seq strategy by simultaneously capturing the BCGs into a single ...
Vincent Libis, Logan W. MacIntyre, Rabia Mehmood, Liliana Guerrero, Melinda A. Ternei, Niv Antonovsky, Ján Burian, Zongqiang Wang, Sean F. Brady   +8 more
doaj   +2 more sources

Activating cryptic biosynthetic gene clusters via ACTIMOT [PDF]

Engineering Microbiology
The mainstream strategy of genome mining relies on the homologous activation and heterologous expression of target biosynthetic gene clusters (BGCs).
Xiaoying Bian
doaj   +2 more sources

Transcriptional Activation of Biosynthetic Gene Clusters in Filamentous Fungi

Frontiers in Bioengineering and Biotechnology, 2022
Filamentous fungi are highly productive cell factories, many of which are industrial producers of enzymes, organic acids, and secondary metabolites. The increasing number of sequenced fungal genomes revealed a vast and unexplored biosynthetic potential ...
László Mózsik, Riccardo Iacovelli, Roel A. L. Bovenberg, Roel A. L. Bovenberg, Arnold J. M. Driessen   +4 more
doaj   +2 more sources

Genome Mining and Characterization of Biosynthetic Gene Clusters in Two Cave Strains of Paenibacillus sp.

Frontiers in Microbiology, 2021
The genome sequencing and mining of microorganisms from unexplored and extreme environments has become important in the process of identifying novel biosynthetic pathways. In the present study, the biosynthetic potential of Paenibacillus sp.
Jolanta Lebedeva, Gabriele Jukneviciute, Rimvydė Čepaitė, Vida Vickackaite, Raminta Pranckutė, Nomeda Kuisiene   +5 more
doaj   +2 more sources

Diversity and distribution of biosynthetic gene clusters in agricultural soil microbiomes [PDF]

mSystems
Bacterial secondary metabolites serve as an important source of molecules for drug discovery. They also play an important function in mediating the interactions of microbial producers with their living environment and surrounding organisms.
Zhiguo Zhang, Lu Zhang, Lihan Zhang, Haiyan Chu, Jizhong Zhou, Feng Ju   +5 more
semanticscholar   +2 more sources

Establishing conserved biosynthetic gene clusters of the phylum Myxococcota [PDF]

Applied and Environmental Microbiology
A surge in sequenced myxobacteria catalyzed by advancements in long-read genome and metagenome sequencing has provided sufficient data to scrutinize the conserved biosynthetic gene clusters (BGCs) within the phylum Myxococcota.
Shailaja Khanal Pokharel, Nawal Shehata, Andrew Ahearne, Thomas Knehans, Constance B. Bailey, Paul D. Boudreau, D. Cole Stevens   +6 more
doaj   +2 more sources

Bioinformatic exploration of RiPP biosynthetic gene clusters in lichens [PDF]

Fungal Biology and Biotechnology
Background Ribosomally synthesized and posttranslationally modified peptides (RiPPs) represent a relatively recent addition to the biosynthetic gene cluster (BGC) repertoire of fungi.
Anna Pasinato, Garima Singh
doaj   +2 more sources

Nisin-like biosynthetic gene clusters are widely distributed across microbiomes [PDF]

mBio
Bacteriocins are antimicrobial peptides/proteins that can have narrow or broad inhibitory spectra and remarkable potency against clinically relevant pathogens.
David Hourigan, Des Field, Ellen Murray, Ivan Sugrue, Paula M. O’Connor, Colin Hill, R. Paul Ross   +6 more
doaj   +2 more sources

A Natural Plasmid Uniquely Encodes Two Biosynthetic Pathways Creating a Potent Anti-MRSA Antibiotic [PDF]

, 2011
Background Understanding how complex antibiotics are synthesised by their producer bacteria is essential for creation of new families of bioactive compounds. Thiomarinols, produced by marine bacteria belonging to the genus Pseudoalteromonas, are hybrids
Cox, Russell J., Crosby, John, Fukuda, Daisuke, Gurney, Rachel, Haines, Anthony S., Hothersall, Joanne, Murphy, Annabel C., Simpson, Thomas J., Song, Zhongshu, Stephens, Elton R., Thomas, Christopher M., Willis, Christine L.   +11 more
core   +19 more sources