Results 31 to 40 of about 356,384 (331)

Strain prioritization and genome mining for enediyne natural products [PDF]

, 2016
The enediyne family of natural products has had a profound impact on modern chemistry, biology, and medicine, and yet only 11 enediynes have been structurally characterized to date.
Ben Shen, Christoph Rader, Dong Yang, Filip Van Nieuwerburgh, Hindra, Huiming Ge, Ivana Crnovčičć, Jeffrey D. Rudolf, Jeremy R. Lohman, Li-Xing Zhao, Qihui Teng, Tingting Huang, Xiangcheng Zhu, Xiaohui Yan, Xiuling Li, Yannick Gansemans, Yanwen Duan, Yi Jiang, Yong Huang   +18 more
core   +6 more sources

Chromatin-level regulation of biosynthetic gene clusters [PDF]

Nature Chemical Biology, 2009
Loss-of-function Aspergillus nidulans CclA, a Bre2 ortholog involved in histone H3 lysine 4 methylation, activated the expression of cryptic secondary metabolite clusters in A. nidulans. One new cluster generated monodictyphenone, emodin and emodin derivatives, whereas a second encoded two anti-osteoporosis polyketides, F9775A and F9775B.
Jin Woo, Bok, Yi-Ming, Chiang, Edyta, Szewczyk, Yazmid, Reyes-Dominguez, Ashley D, Davidson, James F, Sanchez, Hsien-Chun, Lo, Kenji, Watanabe, Joseph, Strauss, Berl R, Oakley, Clay C C, Wang, Nancy P, Keller   +11 more
openaire   +2 more sources

Accurate de novo identification of biosynthetic gene clusters with GECCO

bioRxiv, 2021
Biosynthetic gene clusters (BGCs) are enticing targets for (meta)genomic mining efforts, as they may encode novel, specialized metabolites with potential uses in medicine and biotechnology.
L. Carroll, M. Larralde, J. S. Fleck, R. Ponnudurai, A. Milanese, Elisa Cappio, G. Zeller   +6 more
semanticscholar   +1 more source

Functional Analysis of the Fusarielin Biosynthetic Gene Cluster [PDF]

Molecules, 2016
Fusarielins are polyketides with a decalin core produced by various species of Aspergillus and Fusarium. Although the responsible gene cluster has been identified, the biosynthetic pathway remains to be elucidated. In the present study, members of the gene cluster were deleted individually in a Fusarium graminearum strain overexpressing the local ...
Aida Droce, Wagma Saei, Simon Jørgensen, Reinhard Wimmer, Henriette Giese, Rasmus Wollenberg, Teis Sondergaard, Jens Sørensen   +7 more
openaire   +4 more sources

Expanding our understanding of sequence-function relationships of type II polyketide biosynthetic gene clusters: bioinformatics-guided identification of Frankiamicin A from Frankia sp. EAN1pec. [PDF]

PLoS ONE, 2015
A large and rapidly increasing number of unstudied "orphan" natural product biosynthetic gene clusters are being uncovered in sequenced microbial genomes.
Yasushi Ogasawara, Benjamin J Yackley, Jacob A Greenberg, Snezna Rogelj, Charles E Melançon   +4 more
doaj   +1 more source

Systems and synthetic biology to elucidate secondary metabolite biosynthetic gene clusters encoded in Streptomyces genomes.

Natural product reports (Print), 2021
Covering: 2010 to 2020Over the last few decades, Streptomyces have been extensively investigated for their ability to produce diverse bioactive secondary metabolites. Recent advances in Streptomyces research have been largely supported by improvements in
Namil Lee, Soonkyu Hwang, Woori Kim, Yongjae Lee, J. H. Kim, Suhyung Cho, H. Kim, Y. Yoon, M. Oh, B. Palsson, Byung-Kwan Cho   +10 more
semanticscholar   +1 more source

Epigenetic Activation of Silent Biosynthetic Gene Clusters in Endophytic Fungi Using Small Molecular Modifiers

Frontiers in Microbiology, 2022
The discovery of silent biosynthetic gene clusters (BGCs) in fungi provides unlimited prospects to harness the secondary metabolites encoded by gene clusters for various applications, including pharmaceuticals.
Lynise C. Pillay, Lucpah Nekati, Phuti J. Makhwitine, Sizwe I. Ndlovu   +3 more
semanticscholar   +1 more source

Heterologous Expression of the Unusual Terreazepine Biosynthetic Gene Cluster Reveals a Promising Approach for Identifying New Chemical Scaffolds

mBio, 2020
Advances in genome sequencing have revitalized natural product discovery efforts, revealing the untapped biosynthetic potential of fungi. While the volume of genomic data continues to expand, discovery efforts are slowed due to the time-consuming nature ...
Lindsay K. Caesar, Matthew T. Robey, Michael Swyers, Md N. Islam, Rosa Ye, Purav P. Vagadia, Gary E. Schiltz, Paul M. Thomas, Chengcang C. Wu, Neil L. Kelleher, Nancy P. Keller, Jin Woo Bok   +11 more
doaj   +1 more source

Mining microbial genomes for new natural products and biosynthetic pathways [PDF]

, 2008
Analyses of microbial genome sequences have revealed numerous examples of ‘cryptic’ or ‘orphan’ biosynthetic gene clusters, with the potential to direct the production of novel, structurally complex natural products.
Austin, Austin, Banskota, Banskota, Barona-Gómez, Barona-Gómez, Bentley, Bergmann, Bok, Caffrey, Chain, Challis, Challis, Challis, Challis, Chen, Chen, Corre, de Bruijn, Drake, Erb, Fischbach, Fleischmann, Fleming, Funa, Gregory L. Challis, Gross, Gross, Grüschow, Gust, Günter, Haydock, Haynes, Hojati, Hornung, Ikeda, Izumikawa, Kadi, Keller, Koehn, Larsen, Lautru, Lautru, Li, Li, Lin, Lin, McAlpine, Miethke, Minowa, Miyanaga, Muller, Nguyen, Oliynyk, Omura, Paulsen, Petersen, Pfeifer, Rausch, Reid, Song, Stachelhaus, Sudek, Tohyama, Udwary, Wilkinson, Zhao, Zirkle   +67 more
core   +2 more sources

antiSMASH 3.0—a comprehensive resource for the genome mining of biosynthetic gene clusters

Nucleic Acids Res., 2015
Microbial secondary metabolism constitutes a rich source of antibiotics, chemotherapeutics, insecticides and other high-value chemicals. Genome mining of gene clusters that encode the biosynthetic pathways for these metabolites has become a key ...
T. Weber, K. Blin, Srikanth Duddela, D. Krug, H. Kim, R. Bruccoleri, S. Lee, M. Fischbach, R. Müller, W. Wohlleben, R. Breitling, E. Takano, M. Medema   +12 more
semanticscholar   +1 more source