Results 31 to 40 of about 99,198 (289)

Genome Mining and Characterization of Biosynthetic Gene Clusters in Two Cave Strains of Paenibacillus sp.

Frontiers in Microbiology, 2021
The genome sequencing and mining of microorganisms from unexplored and extreme environments has become important in the process of identifying novel biosynthetic pathways. In the present study, the biosynthetic potential of Paenibacillus sp.
Jolanta Lebedeva, Gabriele Jukneviciute, Rimvydė Čepaitė, Vida Vickackaite, Raminta Pranckutė, Nomeda Kuisiene   +5 more
doaj   +1 more source

Butirosin-biosynthetic Gene Cluster from Bacillus circulans.

The Journal of Antibiotics, 2000
Butirosin is an interesting 2-deoxystreptamine (DOS)-containing aminoglycoside antibiotic produced by non-actinomycete Bacilli. Recently we were successful in purification of 2-deoxy-scyllo-inosose synthase from butirosin-producer Bacillus circulans as the key enzyme for the biosynthesis of DOS, in cloning of the responsible gene (btrC), and in its ...
Yasumasa Ota, Hideyuki Tamegai, Fumitaka Kudo, Hisako Kuriki, Aumi Koike-Takeshita, Tadashi Eguchi, Katsumi Kakinuma   +6 more
openaire   +3 more sources

BiosyntheticSPAdes: reconstructing biosynthetic gene clusters from assembly graphs [PDF]

Genome Research, 2019
Predicting biosynthetic gene clusters (BGCs) is critically important for discovery of antibiotics and other natural products. While BGC prediction from complete genomes is a well-studied problem, predicting BGCs in fragmented genomic assemblies remains challenging.
Dmitry Meleshko, Hosein Mohimani, Vittorio Tracanna, Iman Hajirasouliha, Marnix H. Medema, Anton Korobeynikov, Pavel A. Pevzner   +6 more
openaire   +2 more sources

Identification and analysis of the paulomycin biosynthetic gene cluster and titer improvement of the paulomycins in Streptomyces paulus NRRL 8115. [PDF]

PLoS ONE, 2015
The paulomycins are a group of glycosylated compounds featuring a unique paulic acid moiety. To locate their biosynthetic gene clusters, the genomes of two paulomycin producers, Streptomyces paulus NRRL 8115 and Streptomyces sp. YN86, were sequenced. The
Jine Li, Zhoujie Xie, Min Wang, Guomin Ai, Yihua Chen   +4 more
doaj   +1 more source

The enduracidin biosynthetic gene cluster from Streptomyces fungicidicus [PDF]

Microbiology, 2006
The biosynthetic gene cluster for the 17 aa peptide antibiotic enduracidin has been cloned and sequenced from Streptomyces fungicidicus ATCC 21013. The 84 kb gene cluster contains 25 ORFs and is located within a 116 kb genetic locus that was fully sequenced.
Xihou, Yin, T Mark, Zabriskie
openaire   +2 more sources

Genome Sequences of Serratia Strains Revealed Common Genes in Both Serratomolides Gene Clusters

Biology, 2020
Serratia strains are ubiquitous microorganisms with the ability to produce serratomolides, such as serrawettins. These extracellular lipopeptides are described as biocides against many bacteria and fungi and may have a nematicidal activity against ...
Catarina Marques-Pereira, Diogo Neves Proença, Paula V. Morais   +2 more
doaj   +1 more source

BioCAT: Search for biosynthetic gene clusters producing nonribosomal peptides with known structure

Computational and Structural Biotechnology Journal, 2022
Nonribosomal peptides are a class of secondary metabolites synthesized by multimodular enzymes named nonribosomal peptide synthetases and mainly produced by bacteria and fungi.
Dmitry N. Konanov, Danil V. Krivonos, Elena N. Ilina, Vladislav V. Babenko   +3 more
doaj   +1 more source

MultiMetEval: comparative and multi-objective analysis of genome-scale metabolic models [PDF]

, 2012
Comparative metabolic modelling is emerging as a novel field, supported by the development of reliable and standardized approaches for constructing genome-scale metabolic models in high throughput.
A Freitag, A Gevorgyan, A Mithani, Albert Gevorgyan, AM Feist, AM Feist, AM Feist, Andrzej M. Kierzek, AP Burgard, BA Pfeifer, CS Henry, D Nagrath, DC Alexander, DC Stevens, EM Paradise, Eriko Takano, FC Lee, H Ikeda, I Thiele, J Gonzalez-Lergier, J Romero, J Schellenberger, JD Orth, JL Adrio, JP Brooks, JS Edwards, K Nieselt, K Yanai, LM Blank, M DeJongh, M Durot, M Kanehisa, M Latendresse, MA Fischbach, MA Oberhardt, MA Oberhardt, MA Oberhardt, Marnix H. Medema, MH Medema, MH Medema, MH Medema, MH Medema, MT Alam, MT Alam, MW Covert, N Scherr, ND Price, ND Price, NE Lewis, Piotr Zakrzewski, PR Ives, R Breitling, R Schuetz, Rainer Breitling, SA Becker, SD Bentley, Stephen S. Fong, TD Vo, TY Kim, XQ Zhao   +59 more
core   +6 more sources

Transcriptional regulation of the novobiocin biosynthetic gene cluster [PDF]

Microbiology, 2009
The aminocoumarin antibiotic novobiocin is a gyrase inhibitor formed by a Streptomyces strain. The biosynthetic gene cluster of novobiocin spans 23.4 kb and contains 20 coding sequences, among them the two regulatory genes novE and novG. We investigated the location of transcriptional promoters within this cluster by insertion of transcriptional ...
Dangel, Volker, Härle, Johannes, Goerke, Christiane, Wolz, Christiane, Gust, Bertolt, Pernodet, Jean-Luc, Heide, Lutz   +6 more
openaire   +3 more sources

Systems Biology and Pangenome of Salmonella O-Antigens. [PDF]

, 2019
O-antigens are glycopolymers in lipopolysaccharides expressed on the cell surface of Gram-negative bacteria. Variability in the O-antigen structure constitutes the basis for the establishment of the serotyping schema. We pursued a two-pronged approach to
Kavvas, Erol, Machado, Henrique, Monk, Jonathan M, Palsson, Bernhard O, Seif, Yara   +4 more
core   +2 more sources