Results 41 to 50 of about 356,384 (331)
Microbial Cell Factories, 2017 Background Heterologous expression of biosynthetic gene clusters of natural microbial products has become an essential strategy for titer improvement and pathway engineering of various potentially-valuable natural products.
Hye-rim Pyeon +4 more
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Alternative sigma factor over-expression enables heterologous expression of a type II polyketide biosynthetic pathway in Escherichia coli. [PDF]
PLoS ONE, 2013 BACKGROUND: Heterologous expression of bacterial biosynthetic gene clusters is currently an indispensable tool for characterizing biosynthetic pathways.
David Cole Stevens +5 more
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Marine Drugs, 2022 Marine natural products (MNPs) are an important source of biologically active metabolites, particularly for therapeutic agent development after terrestrial plants and nonmarine microorganisms.
Yushan Xu +6 more
semanticscholar +1 more source
BMC Genomics, 2018 Background Genome mining tools have enabled us to predict biosynthetic gene clusters that might encode compounds with valuable functions for industrial and medical applications.
Martina Adamek +8 more
doaj +1 more source
MIBiG 2.0: a repository for biosynthetic gene clusters of known function
Nucleic Acids Res., 2019 Fueled by the explosion of (meta)genomic data, genome mining of specialized metabolites has become a major technology for drug discovery and studying microbiome ecology.
S. Kautsar +20 more
semanticscholar +1 more source
BiG-SLiCE: A highly scalable tool maps the diversity of 1.2 million biosynthetic gene clusters
bioRxiv, 2020 Background Genome mining for Biosynthetic Gene Clusters (BGCs) has become an integral part of natural product discovery. The >200,000 microbial genomes now publicly available hold information on abundant novel chemistry.
S. Kautsar +3 more
semanticscholar +1 more source
Frontiers in Microbiology, 2021 Species of the genus Streptomyces are known for their ability to produce multiple secondary metabolites; their genomes have been extensively explored to discover new bioactive compounds.
Carlos Caicedo-Montoya +2 more
semanticscholar +1 more source
Biosynthetic Gene Content of the ‘Perfume Lichens’ Evernia prunastri and Pseudevernia furfuracea
Molecules, 2019 Lichen-forming fungi produce a vast number of unique natural products with a wide variety of biological activities and human uses. Although lichens have remarkable potential in natural product research and industry, the molecular mechanisms underlying ...
Anjuli Calchera +3 more
doaj +1 more source
Genomic clustering within functionally related gene families in Ascomycota fungi
Computational and Structural Biotechnology Journal, 2020 Multiple mechanisms collaborate for proper regulation of gene expression. One layer of this regulation is through the clustering of functionally related genes at discrete loci throughout the genome.
Danielle Hagee +3 more
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Scientific Data, 2020 Streptomyces are Gram-positive bacteria of significant industrial importance due to their ability to produce a wide range of antibiotics and bioactive secondary metabolites. Recent advances in genome mining have revealed that Streptomyces genomes possess
Namil Lee +6 more
semanticscholar +1 more source