Results 51 to 60 of about 99,198 (289)

Pass-back chain extension expands multimodular assembly line biosynthesis. [PDF]

, 2020
Modular nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS) enzymatic assembly lines are large and dynamic protein machines that generally effect a linear sequence of catalytic cycles.
Huan, Tao, Moore, Bradley S, Ross, Avena C, Tang, Xiaoyu, Tang, Xiaoyu, Zhang, Jia Jia   +5 more
core  

How consistent are the transcriptome changes associated with cold acclimation in two species of the Drosophila virilis group? [PDF]

, 2015
This work was financially support by a Marie Curie Initial Training Network grant, “Understanding the evolutionary origin of biological diversity” (ITN-2008–213780 SPECIATION), grants from the Academy of Finland to A.H.
A Hoikkala, A Laiho, A Martin, A Sasson, AA Hoffmann, AL Majumder, AR McCune, B Katz, BJ Sinclair, C Canestro, CJ Reaume, CP Downes, D Arbuthnott, D Bell-Pedersen, D J Parker, DW Huang, DW Huang, FA Loewus, H Colinet, H Colinet, HA MacMillan, J Overgaard, J Zhang, JR Hazel, K Xu, KB Storey, KY Xu, L Kivivuori, L Vesala, L Vesala, L Vesala, LH Throckmorton, M G Ritchie, M Kankare, M Kim, M Reis, M Watanabe, M Watanabe, MC Magnone, MD Robinson, MD Robinson, MJ Fitzpatrick, MK Jones, MV Rockman, NM Teets, PR Senthilan, PW Hochachka, R David, R Morales-Hojas, R Niwa, RE Lee, RE Lee, RM Robich, RW Salt, S Anders, S Fowler, S Sahar, S Tweedie, V Kellermann, V Kostal, V Koštál, V Koštál, Vr Koštál, W Block, W Huang, WJ Heitler, WL Shen, X Huang, XL Guan, Y Benjamini, ZD Liu   +70 more
core   +2 more sources

Genome mining reveals novel biosynthetic gene clusters in entomopathogenic bacteria

Scientific Reports, 2023
The discovery of novel bioactive compounds produced by microorganisms holds significant potential for the development of therapeutics and agrochemicals.
Wipanee Meesil, Paramaporn Muangpat, Sutthirat Sitthisak, Triwit Rattanarojpong, Narisara Chantratita, Ricardo A. R. Machado, Yi-Ming Shi, Helge B. Bode, Apichat Vitta, Aunchalee Thanwisai   +9 more
doaj   +1 more source

The erythromycin biosynthetic gene cluster of Aeromicrobium erythreum

Journal of Industrial Microbiology & Biotechnology, 2004
The erythromycin-biosynthetic (ery) gene cluster of Aeromicrobium erythreum was cloned and characterized. The 55.4-kb cluster contains 25 ery genes. Homologues were found for each gene in the previously characterized ery gene cluster from Saccharopolyspora erythraea. In addition, four new predicted ery genes were identified.
Igor A, Brikun, Andrew R, Reeves, William H, Cernota, Minh B, Luu, J Mark, Weber   +4 more
openaire   +2 more sources

Elucidation of the Photorhabdus temperata Genome and Generation of a Transposon Mutant Library To Identify Motility Mutants Altered in Pathogenesis [PDF]

, 2015
The entomopathogenic nematode Heterorhabditis bacteriophora forms a specific mutualistic association with its bacterial partner Photorhabdus temperata.
Abebe-Akele, Feseha, Bullock, Hannah, Durakovic, Umjia, Gately, Jon, Hurst, Sheldon G., IV, Jackobeck, Ryan, Janicki, Erik, Michaels, Brandye, Rowedder, Holli, Tisa, Louis S.   +9 more
core   +2 more sources

Chassis optimization as a cornerstone for the application of synthetic biology based strategies in microbial secondary metabolism

Frontiers in Microbiology, 2015
The increased number of bacterial genome sequencing projects has generated over the last years a large reservoir of genomic information. In silico analysis of this genomic data has renewed the interest in bacterial bioprospecting for bioactive compounds ...
Tiago eBeites, Tiago eBeites, Marta Vaz Mendes, Marta Vaz Mendes   +3 more
doaj   +1 more source

ThioFinder: a web-based tool for the identification of thiopeptide gene clusters in DNA sequences. [PDF]

PLoS ONE, 2012
Thiopeptides are a growing class of sulfur-rich, highly modified heterocyclic peptides that are mainly active against Gram-positive bacteria including various drug-resistant pathogens.
Jing Li, Xudong Qu, Xinyi He, Lian Duan, Guojun Wu, Dexi Bi, Zixin Deng, Wen Liu, Hong-Yu Ou   +8 more
doaj   +1 more source

Identification and Characterization of Mycemycin Biosynthetic Gene Clusters in Streptomyces olivaceus FXJ8.012 and Streptomyces sp. FXJ1.235

Marine Drugs, 2018
Mycemycins A–E are new members of the dibenzoxazepinone (DBP) family, derived from the gntR gene-disrupted deep sea strain Streptomyces olivaceus FXJ8.012Δ1741 and the soil strain Streptomyces sp. FXJ1.235.
Fangying Song, Ning Liu, Minghao Liu, Yihua Chen, Ying Huang   +4 more
doaj   +1 more source

Dithiolopyrrolone Natural Products : Isolation, Synthesis and Biosynthesis [PDF]

, 2013
Peer reviewedPublisher ...
Deng, Hai, Huang, Sheng, Qin, Zhiwei, Yu, Yi   +3 more
core   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source