Results 61 to 70 of about 356,384 (331)

Heterologous expression of the diazaquinomycin biosynthetic gene cluster [PDF]

Journal of Industrial Microbiology and Biotechnology, 2019
Abstract Members of the diazaquinomycin class of natural products have shown potent and selective activity against Mycobacterium tuberculosis. However, poor aqueous solubility has prevented extensive studies in animal models thus far. Our long-term goal is to harness knowledge regarding diazaquinomycin biosynthesis towards the generation
Jana, Braesel, Tuan Anh, Tran, Alessandra S, Eustáquio   +2 more
openaire   +2 more sources

Systems Biology and Pangenome of Salmonella O-Antigens. [PDF]

, 2019
O-antigens are glycopolymers in lipopolysaccharides expressed on the cell surface of Gram-negative bacteria. Variability in the O-antigen structure constitutes the basis for the establishment of the serotyping schema. We pursued a two-pronged approach to
Kavvas, Erol, Machado, Henrique, Monk, Jonathan M, Palsson, Bernhard O, Seif, Yara   +4 more
core   +2 more sources

Recent Advances in Strategies for the Cloning of Natural Product Biosynthetic Gene Clusters

Frontiers in Bioengineering and Biotechnology, 2021
Microbial natural products (NPs) are a major source of pharmacological agents. Most NPs are synthesized from specific biosynthetic gene clusters (BGCs). With the rapid increase of sequenced microbial genomes, large numbers of NP BGCs have been discovered,
Wenfang Wang, Guosong Zheng, Yinhua Lu
semanticscholar   +1 more source

MultiMetEval: comparative and multi-objective analysis of genome-scale metabolic models [PDF]

, 2012
Comparative metabolic modelling is emerging as a novel field, supported by the development of reliable and standardized approaches for constructing genome-scale metabolic models in high throughput.
A Freitag, A Gevorgyan, A Mithani, Albert Gevorgyan, AM Feist, AM Feist, AM Feist, Andrzej M. Kierzek, AP Burgard, BA Pfeifer, CS Henry, D Nagrath, DC Alexander, DC Stevens, EM Paradise, Eriko Takano, FC Lee, H Ikeda, I Thiele, J Gonzalez-Lergier, J Romero, J Schellenberger, JD Orth, JL Adrio, JP Brooks, JS Edwards, K Nieselt, K Yanai, LM Blank, M DeJongh, M Durot, M Kanehisa, M Latendresse, MA Fischbach, MA Oberhardt, MA Oberhardt, MA Oberhardt, Marnix H. Medema, MH Medema, MH Medema, MH Medema, MH Medema, MT Alam, MT Alam, MW Covert, N Scherr, ND Price, ND Price, NE Lewis, Piotr Zakrzewski, PR Ives, R Breitling, R Schuetz, Rainer Breitling, SA Becker, SD Bentley, Stephen S. Fong, TD Vo, TY Kim, XQ Zhao   +59 more
core   +6 more sources

Active and repressed biosynthetic gene clusters have spatially distinct chromosome states

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Clusters of coexpressed and colocalized biosynthetic pathway genes in plants are a paradigmatic example of the nonrandom organization of the eukaryotic genome and present an ideal opportunity to understand the logic of eukaryote gene cluster
Hans-Wilhelm Nützmann, Daniel Doerr, América Ramírez-Colmenero, J. E. Sotelo-Fonseca, E. Wegel, M. Di Stefano, S. Wingett, P. Fraser, L. Hurst, Selene L. Fernandez-Valverde, A. Osbourn   +10 more
semanticscholar   +1 more source

Biosynthesis of Akaeolide and Lorneic Acids and Annotation of Type I Polyketide Synthase Gene Clusters in the Genome of Streptomyces sp. NPS554

Marine Drugs, 2015
The incorporation pattern of biosynthetic precursors into two structurally unique polyketides, akaeolide and lorneic acid A, was elucidated by feeding experiments with 13C-labeled precursors.
Tao Zhou, Hisayuki Komaki, Natsuko Ichikawa, Akira Hosoyama, Seizo Sato, Yasuhiro Igarashi   +5 more
doaj   +1 more source

Recent Advances in Search of Bioactive Secondary Metabolites from Fungi Triggered by Chemical Epigenetic Modifiers

Journal of Fungi, 2023
Genomic analysis has demonstrated that many fungi possess essential gene clusters for the production of previously unobserved secondary metabolites; however, these genes are normally reduced or silenced under most conditions.
Mengyao Xue, Xuwen Hou, Jiajin Fu, Jiayin Zhang, Jiacheng Wang, Zhitong Zhao, Dan Xu, Daowan Lai, Ligang Zhou   +8 more
doaj   +1 more source

Phylogenomic analysis of natural products biosynthetic gene clusters allows discovery of arseno-organic metabolites in model streptomycetes [PDF]

, 2016
We are indebted with Marnix Medema, Paul Straight and Sean Rovito, for useful discussions and critical reading of the manuscript, as well as with Alicia Chagolla and Yolanda Rodriguez of the MS Service of Unidad Irapuato, Cinvestav, and Araceli Fernandez
Barona-Gomez, Francisco, Cruz-Morales, Pablo, Feldmann, Jorg, Kopp, Johannes Florian, Martinez-Guerrero, Christian, Mojica, Nelly Selem, Ramos-Aboites, Hilda, Yáñez-Guerra, Luis Alfonso   +7 more
core   +1 more source

Climate-specific biosynthetic gene clusters in populations of a lichen-forming fungus.

Environmental Microbiology, 2021
Natural products can contribute to abiotic stress tolerance in plants and fungi. We hypothesize that biosynthetic gene clusters (BGCs), the genomic elements that underlie natural product biosynthesis, display structured differences along elevation ...
Garima Singh, Anjuli Calchera, Meike Schulz, M. Drechsler, H. Bode, I. Schmitt, Francesco Dal Grande   +6 more
semanticscholar   +1 more source

mSphere of Influence: Systematically Decoding Microbial Chemical Communication

mSphere, 2019
Laura A. Mike works in the field of bacterial pathogenesis. In this mSphere of Influence article, she reflects on how “Insights into Secondary Metabolism from a Global Analysis of Prokaryotic Biosynthetic Gene Clusters” by P. Cimermancic et al. (Cell 158:
Laura A. Mike
doaj   +1 more source