Results 71 to 80 of about 356,384 (331)

A widely distributed genus of soil Acidobacteria genomically enriched in biosynthetic gene clusters

open access: yesISME Communications, 2021
Bacteria of the phylum Acidobacteria are one of the most abundant groups across soil ecosystems, yet they are represented by comparatively few sequenced genomes, leaving gaps in our understanding of their metabolic diversity.
A. Crits-Christoph   +4 more
semanticscholar   +1 more source

Exploring the biosynthetic gene clusters in Brevibacterium: a comparative genomic analysis of diversity and distribution

open access: yesBMC Genomics, 2023
Exploring Brevibacterium strains from various ecosystems may lead to the discovery of new antibiotic-producing strains. Brevibacterium sp. H-BE7, a strain isolated from marine sediments from Northern Patagonia, Chile, had its genome sequenced to study ...
Andrés Cumsille   +8 more
doaj   +1 more source

Biosynthesis of thiocarboxylic acid-containing natural products. [PDF]

open access: yes, 2018
Thiocarboxylic acid-containing natural products are rare and their biosynthesis and biological significance remain unknown. Thioplatensimycin (thioPTM) and thioplatencin (thioPTN), thiocarboxylic acid congeners of the antibacterial natural products ...
Deng, Youchao   +9 more
core   +1 more source

Deletion of a hybrid NRPS‐T1PKS biosynthetic gene cluster via Latour gene knockout system in Saccharopolyspora pogona and its effect on butenyl‐spinosyn biosynthesis and growth development

open access: yesMicrobial Biotechnology, 2021
Summary Butenyl‐spinosyn, a promising biopesticide produced by Saccharopolyspora pogona, exhibits stronger insecticidal activity and a broader pesticidal spectrum. However, its titre in the wild‐type S.
Jie Rang   +14 more
doaj   +1 more source

Elucidation of the Photorhabdus temperata Genome and Generation of a Transposon Mutant Library To Identify Motility Mutants Altered in Pathogenesis [PDF]

open access: yes, 2015
The entomopathogenic nematode Heterorhabditis bacteriophora forms a specific mutualistic association with its bacterial partner Photorhabdus temperata.
Abebe-Akele, Feseha   +9 more
core   +2 more sources

Pass-back chain extension expands multimodular assembly line biosynthesis. [PDF]

open access: yes, 2020
Modular nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS) enzymatic assembly lines are large and dynamic protein machines that generally effect a linear sequence of catalytic cycles.
Huan, Tao   +5 more
core  

Dithiolopyrrolone Natural Products : Isolation, Synthesis and Biosynthesis [PDF]

open access: yes, 2013
Peer reviewedPublisher ...
Deng, Hai   +3 more
core   +2 more sources

Genome mining of biosynthetic and chemotherapeutic gene clusters in Streptomyces bacteria

open access: yesScientific Reports, 2020
Streptomyces bacteria are known for their prolific production of secondary metabolites, many of which have been widely used in human medicine, agriculture and animal health.
Kaitlyn C Belknap   +3 more
semanticscholar   +1 more source

An Isotopic Labeling Approach Linking Natural Products with Biosynthetic Gene Clusters

open access: yesNature Chemical Biology, 2021
Major advances in genome sequencing and large-scale biosynthetic gene cluster (BGC) analysis have prompted an age of natural product discovery driven by genome mining. Still, connecting molecules to their cognate BGCs is a substantial bottleneck for this
C. McCaughey   +4 more
semanticscholar   +1 more source

CRISPR-mediated activation of biosynthetic gene clusters for bioactive molecule discovery in filamentous fungi

open access: yesbioRxiv, 2020
Accessing the full biosynthetic potential encoded in the genomes of fungi is limited by the low expression of most biosynthetic gene clusters (BGCs) under common laboratory culture conditions.
Indra Roux   +5 more
semanticscholar   +1 more source

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