Results 81 to 90 of about 356,384 (331)

Recent Advances in Strategies for Activation and Discovery/Characterization of Cryptic Biosynthetic Gene Clusters in Streptomyces

Microorganisms, 2020
Streptomyces spp. are prolific sources of valuable natural products (NPs) that are of great interest in pharmaceutical industries such as antibiotics, anticancer chemotherapeutics, immunosuppressants, etc.
Chung Thanh Nguyen, D. Dhakal, V. H. T. Pham, H. Nguyen, J. Sohng   +4 more
semanticscholar   +1 more source

The erythromycin biosynthetic gene cluster of Aeromicrobium erythreum

Journal of Industrial Microbiology & Biotechnology, 2004
The erythromycin-biosynthetic (ery) gene cluster of Aeromicrobium erythreum was cloned and characterized. The 55.4-kb cluster contains 25 ery genes. Homologues were found for each gene in the previously characterized ery gene cluster from Saccharopolyspora erythraea. In addition, four new predicted ery genes were identified.
Igor A, Brikun, Andrew R, Reeves, William H, Cernota, Minh B, Luu, J Mark, Weber   +4 more
openaire   +2 more sources

Chassis optimization as a cornerstone for the application of synthetic biology based strategies in microbial secondary metabolism

Frontiers in Microbiology, 2015
The increased number of bacterial genome sequencing projects has generated over the last years a large reservoir of genomic information. In silico analysis of this genomic data has renewed the interest in bacterial bioprospecting for bioactive compounds ...
Tiago eBeites, Tiago eBeites, Marta Vaz Mendes, Marta Vaz Mendes   +3 more
doaj   +1 more source

ThioFinder: a web-based tool for the identification of thiopeptide gene clusters in DNA sequences. [PDF]

PLoS ONE, 2012
Thiopeptides are a growing class of sulfur-rich, highly modified heterocyclic peptides that are mainly active against Gram-positive bacteria including various drug-resistant pathogens.
Jing Li, Xudong Qu, Xinyi He, Lian Duan, Guojun Wu, Dexi Bi, Zixin Deng, Wen Liu, Hong-Yu Ou   +8 more
doaj   +1 more source

Identification and Characterization of Mycemycin Biosynthetic Gene Clusters in Streptomyces olivaceus FXJ8.012 and Streptomyces sp. FXJ1.235

Marine Drugs, 2018
Mycemycins A–E are new members of the dibenzoxazepinone (DBP) family, derived from the gntR gene-disrupted deep sea strain Streptomyces olivaceus FXJ8.012Δ1741 and the soil strain Streptomyces sp. FXJ1.235.
Fangying Song, Ning Liu, Minghao Liu, Yihua Chen, Ying Huang   +4 more
doaj   +1 more source

How consistent are the transcriptome changes associated with cold acclimation in two species of the Drosophila virilis group? [PDF]

, 2015
This work was financially support by a Marie Curie Initial Training Network grant, “Understanding the evolutionary origin of biological diversity” (ITN-2008–213780 SPECIATION), grants from the Academy of Finland to A.H.
A Hoikkala, A Laiho, A Martin, A Sasson, AA Hoffmann, AL Majumder, AR McCune, B Katz, BJ Sinclair, C Canestro, CJ Reaume, CP Downes, D Arbuthnott, D Bell-Pedersen, D J Parker, DW Huang, DW Huang, FA Loewus, H Colinet, H Colinet, HA MacMillan, J Overgaard, J Zhang, JR Hazel, K Xu, KB Storey, KY Xu, L Kivivuori, L Vesala, L Vesala, L Vesala, LH Throckmorton, M G Ritchie, M Kankare, M Kim, M Reis, M Watanabe, M Watanabe, MC Magnone, MD Robinson, MD Robinson, MJ Fitzpatrick, MK Jones, MV Rockman, NM Teets, PR Senthilan, PW Hochachka, R David, R Morales-Hojas, R Niwa, RE Lee, RE Lee, RM Robich, RW Salt, S Anders, S Fowler, S Sahar, S Tweedie, V Kellermann, V Kostal, V Koštál, V Koštál, Vr Koštál, W Block, W Huang, WJ Heitler, WL Shen, X Huang, XL Guan, Y Benjamini, ZD Liu   +70 more
core   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

The role of the phosphopantetheinyltransferase enzyme, PswP, in the biosynthesis of antimicrobial secondary metabolites by Serratia marcescens Db10 [PDF]

, 2014
Phosphopantetheinyltransferase (PPTase) enzymes fulfil essential roles in primary and secondary metabolism in prokaryotes, archaea and eukaryotes. PPTase enzymes catalyse the essential modification of the carrier protein domain of fatty acid synthases ...
Amy J. Gerc, Elovson, Flyg, Herrero, Matsuyama, Nicola R. Stanley-Wall, Perego, Persmark, Sarah J. Coulthurst, Seyedsayamdost   +9 more
core   +4 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Phylogenetic Comparison of Swainsonine Biosynthetic Gene Clusters among Fungi

Journal of Fungi, 2022
Swainsonine is a cytotoxic alkaloid produced by fungi. Genome sequence analyses revealed that these fungi share an orthologous gene cluster, SWN, necessary for swainsonine biosynthesis.
Marwa Neyaz, Sumanjari Das, Daniel Cook, Rebecca Creamer   +3 more
doaj   +1 more source