Results 61 to 70 of about 177,877 (294)

Bioprospecting Red Sea Coastal Ecosystems for Culturable Microorganisms and Their Antimicrobial Potential

Marine Drugs, 2016
Microorganisms that inhabit unchartered unique soil such as in the highly saline and hot Red Sea lagoons on the Saudi Arabian coastline, represent untapped sources of potentially new bioactive compounds.
Soha Al-Amoudi, Magbubah Essack, Marta F. Simões, Salim Bougouffa, Irina Soloviev, John A. C. Archer, Feras F. Lafi, Vladimir B. Bajic   +7 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Plastidial and ER Triacylglycerol Biosynthesis in a Growth Phase-Dependent Manner in the Heterokont Nannochloropsis oceanica

Frontiers in Marine Science, 2020
Though microalgae have been considered the potential resource for lipid production, native strains are unable to meet the industrial demand. Here, we aim to uncover the complex molecular relationship between algal growth and lipid accumulation ...
Dan Huang, Da-Wei Li, Srinivasan Balamurugan, Jian-Wei Zheng, Wan-Jun Liu, Li-Gong Zou, Wei-Dong Yang, Jie-Sheng Liu, Hong-Ye Li   +8 more
doaj   +1 more source

Reference gene selection for real‐time quantitative PCR assays in different tissues of Huperzia serrata based on full‐length transcriptome sequencing

Plant Direct, 2021
Huperzia serrata (H. serrata) produces various types of effective lycopodium alkaloids, especially Huperzine A (HupA), which is a promising drug for the treatment of Alzheimer's disease.
Yanping Fu, Fei Niu, Hui Jia, Yanli Wang, Bin Guo, Yahui Wei   +5 more
doaj   +1 more source

Butirosin-biosynthetic Gene Cluster from Bacillus circulans.

The Journal of Antibiotics, 2000
Butirosin is an interesting 2-deoxystreptamine (DOS)-containing aminoglycoside antibiotic produced by non-actinomycete Bacilli. Recently we were successful in purification of 2-deoxy-scyllo-inosose synthase from butirosin-producer Bacillus circulans as the key enzyme for the biosynthesis of DOS, in cloning of the responsible gene (btrC), and in its ...
Yasumasa Ota, Hideyuki Tamegai, Fumitaka Kudo, Hisako Kuriki, Aumi Koike-Takeshita, Tadashi Eguchi, Katsumi Kakinuma   +6 more
openaire   +3 more sources

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

CRAGE-CRISPR facilitates rapid activation of secondary metabolite biosynthetic gene clusters in bacteria [PDF]

, 2021
Ke Jing, David S. Robinson, Zong‐Yen Wu, Andrea Kuftin, Katherine Louie, Suzanne M. Kosina, Trent R. Northen, Jan‐Fang Cheng, Yasuo Yoshikuni   +8 more
openalex   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

Integrated metabolomic and transcriptomic analysis reveals the biosynthesis mechanism of dihydrochalcones in sweet tea (Lithocarpus litseifolius)

Frontiers in Plant Science
The demand for plant-based, low-calorie natural sweeteners is increasing. Four dihydrochalcones (DHCs), namely phloretin, phlorizin, trilobatin, and sieboldin, have been identified in the leaves of Lithocarpus litseifolius.
Shaojun Ling, Shaojun Ling, Shaojun Ling, Qiongqiong Lin, Qiongqiong Lin, Qiongqiong Lin, Biaofeng Zhou, Biaofeng Zhou, Biaofeng Zhou, Yiye Liang, Yiye Liang, Yiye Liang, Wenji Luo, Wenji Luo, Wenji Luo, Zhao Shen, Zhao Shen, Zhao Shen, Jingshu Wang, Jingshu Wang, Jingshu Wang, Jingwei Niu, Jingwei Niu, Jingwei Niu, Liangjing Qiao, Liangjing Qiao, Liangjing Qiao, Baosheng Wang, Baosheng Wang, Baosheng Wang, Hui Liu, Hui Liu, Hui Liu   +32 more
doaj   +1 more source

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source