Results 81 to 90 of about 1,441,063 (301)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Breeding Novel Chemistry in Willow: New Hetero Diels–Alder Cyclodimers from Arbusculoidin and Salicortin Suggest Parallel Biosynthetic Pathways [PDF]

An investigation of phenolic glycosides extracted from Salix germplasm revealed that arbusculoidin (benzyl 1-O-β-d-glucopyranosyl-1-hydroxy-6-oxo-2-cyclohexenyl carboxylate) and its enolic 6-glycoside isomer, isoarbusculoidin, are widespread across the ...
Claudia Harflett, Noleto-Dias, C., Hanley, S. J., Michael H. Beale, Beale, M. H., Alice Bellisai, Gianluca Ruvo, Steven J. Hanley, Lomax, C., William J. Macalpine, Harflett, C., Clarice Noleto-Dias, Jane L. Ward, Ruvo, G., Charlotte Lomax, Macalpine, W. J., Bellisai, A., Ward, J. L.   +17 more
core   +1 more source

Harnessing Microbial Biosynthetic Pathways for the Production of Complex Molecules

, 2020
Heterologous biosynthetic pathway expression is an essential tool for natural products biochemists. It has provided a powerful methodology for elucidating and characterizing bacterial biosynthetic pathways.
Hassan, Mohamed
core   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Norspermidine is not a self-produced trigger for biofilm disassembly [PDF]

, 2014
Formation of Bacillus subtilis biofilms, consisting of cells encapsulated within an extracellular matrix of exopolysaccharide and protein, requires the polyamine spermidine.
Stanley-Wall, Nicola R.; id_orcid, Hobley, Laura, Kim, Sok Ho, Stanley-Wall, Nicola R., Michael, Anthony J., Maezato, Yukari, Fairlamb, Alan H.; id_orcid, Fairlamb, Alan H., Wyllie, Susan   +8 more
core   +1 more source

Biosynthetic Potential of Hypogymnia Holobionts: Insights into Secondary Metabolite Pathways

, 2023
Lichens are symbiotic associations consisting of a photobiont (algae or cyanobacteria) and a mycobiont (fungus). They are known to produce a variety of unique secondary metabolites. To access this biosynthetic potential for biotechnological applications,
Imke Schmitt, Thomas Brueck, Jürgen Otte, Manfred Ritz, Anjuli Calchera, Nadim Ahmad, Norbert Mehlmer   +6 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Metabolic engineering of the purine biosynthetic pathway in Corynebacterium glutamicum results in increased intracellular pool sizes of IMP and hypoxanthine [PDF]

, 2012
Background: Purine nucleotides exhibit various functions in cellular metabolism. Besides serving as building blocks for nucleic acid synthesis, they participate in signaling pathways and energy metabolism.
Sarah Zimmet, Susanne Peifer, Elmar Heinzle, Heinzle, Elmar, Dietrich A Volmer, Schneider, Konstantin, Konstantin Schneider, Barduhn, Tobias, Volmer, Dietrich A., Tobias Barduhn, Zimmet, Sarah, Peifer, Susanne   +11 more
core   +1 more source

Interdependence of Shigella flexneri O Antigen and Enterobacterial Common Antigen Biosynthetic Pathways

, 2022
Outer membrane (OM) polysaccharides allow bacteria to resist harsh environmental conditions and antimicrobial agents, traffic to and persist in pathogenic niches, and evade immune responses.
Maczuga, N., Morona, Renato, Qin, J., Maczuga, Nicholas, Qin, Jilong, Tran, Elizabeth N. H., Tran, E.N.H., Morona, R.   +7 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source