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Biotin

Cold Spring Harbor Protocols, 2021
Biotin is a water-soluble vitamin that can be attached to a variety of proteins and nucleic acids, often without altering their properties. Its use in molecular biology is introduced here.
Michael R, Green, Joseph, Sambrook
semanticscholar   +4 more sources

Biotin conjugates in targeted drug delivery: is it mediated by a biotin transporter, a yet to be identified receptor, or (an)other unknown mechanism(s)?

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Conjugation of drugs with biotin is a widely studied strategy for targeted drug delivery. The structure–activity relationship (SAR) studies through H3-biotin competition experiments conclude with the presence of a free carboxylic acid being essential for
Ravi Tripathi, Anchala Guglani, Rujuta Ghorpade, Binghe Wang   +3 more
doaj   +2 more sources

Impairment of gut microbial biotin metabolism and host biotin status in severe obesity: effect of biotin and prebiotic supplementation on improved metabolism

Gut, 2022
Objectives Gut microbiota is a key component in obesity and type 2 diabetes, yet mechanisms and metabolites central to this interaction remain unclear. We examined the human gut microbiome’s functional composition in healthy metabolic state and the most ...
Eugeni Belda, Lise Voland, Valentina Tremaroli   +2 more
exaly   +2 more sources

Biotin methyl ester enhances cargo release in RUSH system and enables rapid biotinylation with TurboID [PDF]

Communications Biology
Biotin-streptavidin technology is a key tool in biotechnology. The engineering of streptavidin or streptavidin-like molecules and organic synthesis of biotin derivatives offer a variety of applications to meet the needs of researchers.
Taisei Uehara, Arata Takiguchi, Takuro Tojima, Akihiko Nakano, Shion Kagawa, Tatsuo Nehira, Takunori Satoh, Akiko K. Satoh   +7 more
doaj   +2 more sources

Antibodies to biotin enable large-scale detection of biotinylation sites on proteins

Nature Methods, 2017
Although purification of biotinylated molecules is highly efficient, identifying specific sites of biotinylation remains challenging. We show that anti-biotin antibodies enable unprecedented enrichment of biotinylated peptides from complex peptide ...
N. Udeshi, Kayvon Pedram, Tanya Svinkina, Shaunt Fereshetian, S. Myers, Ozan Aygun, Karsten Krug, K. Clauser, Dominic Ryan, Tslil Ast, V. Mootha, A. Ting, S. Carr   +12 more
semanticscholar   +3 more sources

Biotin-mediated drug delivery: does the biotin transporter mediate uptake of biotin conjugates? [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry
Sodium-dependent multivitamin transporter (SMVT) is a biotin transporter over-expressed in various types of cancer cells and is commonly studied for targeted drug delivery using biotin conjugates.
Ravi Tripathi, Xiaoxiao Yang, Dongning Liu, Wen Lu, Binghe Wang   +4 more
doaj   +2 more sources

Biotin [PDF]

BioFactors, 2009
AbstractBiotin is a water‐soluble vitamin and serves as a coenzyme for five carboxylases in humans. Biotin is also covalently attached to distinct lysine residues in histones, affecting chromatin structure and mediating gene regulation. This review describes mammalian biotin metabolism, biotin analysis, markers of biotin status, and biological ...
Janos, Zempleni, Subhashinee S K, Wijeratne, Yousef I, Hassan   +2 more
openaire   +4 more sources

Synthetic mimics of biotin/(strept)avidin

Chemical Society Reviews, 2017
Wenqi Liu, Soumen Kumar Samanta, Bradley D Smith   +2 more
exaly   +2 more sources

The growth responses and antioxidant capabilities of melinjo (Gnetum gnemon L.) in different durations of drought stress

Annals of Agricultural Sciences, 2021
Melinjo (Gnetum gnemon L.) is a beneficial agroforestry plant that contains antioxidant compounds broadly studied as a natural source in pharmaceutical and nutraceutical uses.
Tri Agus Siswoyo, Laras Sekar Arum, Bella Rhea Lavifa Sanjaya, Zahela Siti Aisyah   +3 more
doaj   +1 more source

Chlorin e6-Biotin Conjugates for Tumor-Targeting Photodynamic Therapy

Molecules, 2021
To improve the tumor-targeting efficacy of photodynamic therapy, biotin was conjugated with chlorin e6 to develop a new tumor-targeting photosensitizer, Ce6-biotin. The Ce6-biotin had good water solubility and low aggregation.
Wei Liu, Xingqun Ma, Yingying Jin, Jie Zhang, Yang Li, Yuxia Tang, Yong Song, Shouju Wang   +7 more
doaj   +1 more source