Results 1 to 10 of about 467,470 (351)
Mechanisms of biotin-regulated gene expression in microbes [PDF]
Synthetic and Systems Biotechnology, 2016 Biotin is an essential micronutrient that acts as a co-factor for biotin-dependent metabolic enzymes. In bacteria, the supply of biotin can be achieved by de novo synthesis or import from exogenous sources.
J. Satiaputra +3 more
doaj +3 more sources
Biotin methyl ester enhances cargo release in RUSH system and enables rapid biotinylation with TurboID [PDF]
Communications BiologyBiotin-streptavidin technology is a key tool in biotechnology. The engineering of streptavidin or streptavidin-like molecules and organic synthesis of biotin derivatives offer a variety of applications to meet the needs of researchers.
Taisei Uehara +7 more
doaj +2 more sources
Biotin-mediated drug delivery: does the biotin transporter mediate uptake of biotin conjugates? [PDF]
Journal of Enzyme Inhibition and Medicinal ChemistrySodium-dependent multivitamin transporter (SMVT) is a biotin transporter over-expressed in various types of cancer cells and is commonly studied for targeted drug delivery using biotin conjugates.
Ravi Tripathi +4 more
doaj +2 more sources
BioFactors, 2009 AbstractBiotin is a water‐soluble vitamin and serves as a coenzyme for five carboxylases in humans. Biotin is also covalently attached to distinct lysine residues in histones, affecting chromatin structure and mediating gene regulation. This review describes mammalian biotin metabolism, biotin analysis, markers of biotin status, and biological ...
Janos, Zempleni +2 more
openaire +4 more sources
Annals of Agricultural Sciences, 2021 Melinjo (Gnetum gnemon L.) is a beneficial agroforestry plant that contains antioxidant compounds broadly studied as a natural source in pharmaceutical and nutraceutical uses.
Tri Agus Siswoyo +3 more
doaj +1 more source
Chlorin e6-Biotin Conjugates for Tumor-Targeting Photodynamic Therapy
Molecules, 2021 To improve the tumor-targeting efficacy of photodynamic therapy, biotin was conjugated with chlorin e6 to develop a new tumor-targeting photosensitizer, Ce6-biotin. The Ce6-biotin had good water solubility and low aggregation.
Wei Liu +7 more
doaj +1 more source
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 Conjugation of drugs with biotin is a widely studied strategy for targeted drug delivery. The structure–activity relationship (SAR) studies through H3-biotin competition experiments conclude with the presence of a free carboxylic acid being essential for
Ravi Tripathi +3 more
doaj +1 more source
Ligand specificity of group I biotin protein ligase of Mycobacterium tuberculosis. [PDF]
PLoS ONE, 2008 BACKGROUND: Fatty acids are indispensable constituents of mycolic acids that impart toughness & permeability barrier to the cell envelope of M. tuberculosis.
Sudha Purushothaman +4 more
doaj +1 more source
Sensors, 2023 Biotin, or vitamin B7, is essential for metabolic reactions. It must be obtained from external sources such as food and biotin/vitamin supplements because it is not biosynthesized by mammals.
Fatema Kaladari +4 more
doaj +1 more source
A Substrate-induced Biotin Binding Pocket in the Carboxyltransferase Domain of Pyruvate Carboxylase [PDF]
, 2013 Biotin-dependent enzymes catalyze carboxyl transfer reactions by efficiently coordinating multiple reactions between spatially distinct active sites. Pyruvate carboxylase (PC), a multifunctional biotin-dependent enzyme, catalyzes the bicarbonate- and ...
Lietzan, Adam D, Maurice, Martin St.
core +2 more sources