Results 11 to 20 of about 488,335 (365)

Mechanisms of biotin-regulated gene expression in microbes [PDF]

Synthetic and Systems Biotechnology, 2016
Biotin is an essential micronutrient that acts as a co-factor for biotin-dependent metabolic enzymes. In bacteria, the supply of biotin can be achieved by de novo synthesis or import from exogenous sources.
J. Satiaputra, K.E. Shearwin, G.W. Booker, S.W. Polyak   +3 more
doaj   +3 more sources

Heterogeneous and rate-dependent streptavidin-biotin unbinding revealed by high-speed force spectroscopy and atomistic simulations [PDF]

, 2018
Receptor-ligand interactions are essential for biological function and their binding strength is commonly explained in terms of static lock-and-key models based on molecular complementarity. However, detailed information of the full unbinding pathway is often lacking due, in part, to the static nature of atomic structures and ensemble averaging ...
Gonzalez, Laura, Grubmuller, Helmut, Rico, Felix, Russek, Andreas, Scheuring, Simon   +4 more
arxiv   +6 more sources

Biotin interference in routine clinical immunoassays [PDF]

Practical Laboratory Medicine
Background: Laboratory examinations play a crucial role in medical diagnostics and treatment, necessitating the identification of interference factors to ensure accurate results.
Kuo-Chun Chiu, Jia-Rong Jhan, Hsiao-Ni Yan, Yu-Chen Liao, Wen-Hui Lu, Kuan-Yi Lee, Li-Yuan Cheng, Chung-Kang Yeh, Ya-Fen Lee, Chiung-Hui Kuo, Kuei-Pin Chung, Tzu-I Chien   +11 more
doaj   +2 more sources

Impairment of gut microbial biotin metabolism and host biotin status in severe obesity: effect of biotin and prebiotic supplementation on improved metabolism

Gut, 2022
Objectives Gut microbiota is a key component in obesity and type 2 diabetes, yet mechanisms and metabolites central to this interaction remain unclear. We examined the human gut microbiome’s functional composition in healthy metabolic state and the most ...
Eugeni Belda, Lise Voland, V. Tremaroli, G. Falony, S. Adriouch, K. Assmann, Edi Prifiti, J. Aron‐Wisnewsky, Jean Debédat, T. Le Roy, T. Nielsen, C. Amouyal, S. André, F. Andreelli, M. Blüher, R. Chakaroun, J. Chilloux, Luis Pedro Coelho, M. Dao, Promi Das, S. Fellahi, Sofia K. Forslund, N. Galleron, T. Hansen, B. Holmes, B. Ji, Helle Krogh Pedersen, Phuong Le, E. Le Chatelier, C. Lewinter, L. Mannerås-Holm, Florian Marquet, A. Myridakis, V. Pelloux, N. Pons, B. Quinquis, C. Rouault, H. Roume, J. Salem, Nataliya Sokolovska, Nadja B. Søndertoft, S. Touch, S. Vieira-Silva, P. Galan, J. Holst, J. Gøtze, L. Køber, H. Vestergaard, T. Hansen, S. Hercberg, J. Oppert, J. Nielsen, Ivica Letunic, M. Dumas, M. Stumvoll, O. Pedersen, P. Bork, S. Ehrlich, Jean-Daniel Zucker, F. Bäckhed, J. Raes, K. Clément   +61 more
semanticscholar   +1 more source

Chlorin e6-Biotin Conjugates for Tumor-Targeting Photodynamic Therapy

Molecules, 2021
To improve the tumor-targeting efficacy of photodynamic therapy, biotin was conjugated with chlorin e6 to develop a new tumor-targeting photosensitizer, Ce6-biotin. The Ce6-biotin had good water solubility and low aggregation.
Wei Liu, Xingqun Ma, Yingying Jin, Jie Zhang, Yang Li, Yuxia Tang, Yong Song, Shouju Wang   +7 more
doaj   +1 more source

Biotin, a universal and essential cofactor: Synthesis, ligation and regulation.

FEMS Microbiology Reviews, 2021
Biotin is a covalently attached enzyme cofactor required for intermediary metabolism in all three domains of life. Several important human pathogens (e.g. Mycobacterium tuberculosis) require biotin synthesis for pathogenesis.
Chaiyos Sirithanakorn, J. Cronan
semanticscholar   +1 more source

Biotin's Lessons in Drug Design.

Journal of Medicinal Chemistry, 2021
At the heart of drug design is the discovery of molecules that bind with high affinity to their drug targets. Biotin forms the strongest known noncovalent ligand-protein interactions with avidin and streptavidin, achieving femtomolar and picomolar ...
D. McConnell
semanticscholar   +1 more source

Biotin conjugates in targeted drug delivery: is it mediated by a biotin transporter, a yet to be identified receptor, or (an)other unknown mechanism(s)?

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Conjugation of drugs with biotin is a widely studied strategy for targeted drug delivery. The structure–activity relationship (SAR) studies through H3-biotin competition experiments conclude with the presence of a free carboxylic acid being essential for
Ravi Tripathi, Anchala Guglani, Rujuta Ghorpade, Binghe Wang   +3 more
doaj   +1 more source

Ligand specificity of group I biotin protein ligase of Mycobacterium tuberculosis. [PDF]

PLoS ONE, 2008
BACKGROUND: Fatty acids are indispensable constituents of mycolic acids that impart toughness & permeability barrier to the cell envelope of M. tuberculosis.
Sudha Purushothaman, Garima Gupta, Richa Srivastava, Vasanthakumar Ganga Ramu, Avadhesha Surolia   +4 more
doaj   +1 more source

Effect of supplementation of biotin in total mixed ration of dairy cows on rumen fermentation characteristics by in vitro gas production technique [PDF]

Journal of Veterinary and Animal Sciences, 2022
An experiment was conducted to assess the effect of supplementation of biotin on rumen fermentation parameters and microbial biomass production by in vitro gas production technique. Biotin was supplemented to the substrate - total mixed ration (TMR) at
K. Jasmine Rani, V. Dildeep, K. Ally, K. M. Syam Mohan, T. V. Aravindakshan, K. S. Anil   +5 more
doaj   +1 more source