Results 161 to 170 of about 117,043 (340)

Identification of human metabolites of fast skeletal troponin activators Tirasemtiv and Reldesemtiv for doping control purposes

open access: yesDrug Testing and Analysis, EarlyView.
The metabolism and urinary elimination of two substances recently classified as prohibited substances in sport was conducted, yielding suitable target analytes for efficient doping controls employing routinely applied chromatographic‐mass spectrometric test methods.
Luisa Euler   +4 more
wiley   +1 more source

Greening the Production of Indigo Blue Exploiting Light and a Recombinant Synechocystis sp. PCC6803 Strain Expressing the Enzyme mFMO. [PDF]

open access: yesMicrob Biotechnol
We developed a sustainable lab‐scale method for producing bio‐indigo using an engineered Synechocystis sp. PCC6803 strain expressing the enzyme mFMO and light. Optimised growth conditions yielded 112 mg/L of bio‐indigo. A new purification technique using polyamide nets allows efficient recovery from the culture medium, reducing environmental impact ...
Loprete G   +5 more
europepmc   +2 more sources

Trifluoroethanol and Halothane Biotransformation in Man [PDF]

open access: bronze, 1971
H. F. Cascorbi, David A. Blake
openalex   +1 more source

Human phase‐I metabolism of three synthetic cannabinoids bearing a cumyl moiety and a cyclobutyl methyl or norbornyl methyl tail: Cumyl‐CBMEGACLONE, Cumyl‐NBMEGACLONE, and Cumyl‐NBMINACA

open access: yesDrug Testing and Analysis, EarlyView.
The human phase‐I metabolism of three SCRAs bearing a cumyl moiety and a CBM or NBM tail, based on LC‐qToF‐MS data of authentic urine specimens. Abstract Synthetic cannabinoid receptor agonists (SCRAs) continue to show high prevalence on the new psychoactive substances drug market.
Arianna Giorgetti   +6 more
wiley   +1 more source

Design and conduct considerations for studies in patients with hepatic impairment

open access: yesClinical and Translational Science, Volume 16, Issue 1, Page 50-61, January 2023., 2023
Abstract Despite the liver being the primary site for clearance of xenobiotics utilizing a myriad of mechanisms ranging from cytochrome P450 enzyme pathways, glucuronidation, and biliary excretion, there is a dearth of information available as to how the severity of hepatic impairment (HI) can alter drug absorption and disposition (i.e ...
Paulien Ravenstijn   +5 more
wiley   +1 more source

Pharmacokinetics of Ethyl Glucuronide and Ethyl Sulfate and Pharmacodynamic Effects Following Intravenous and Oral Administration of Ethanol to Exercised Horses

open access: yesDrug Testing and Analysis, EarlyView.
This study describes the pharmacokinetics of ethanol metabolites following intravenous and oral administration to horses. Based on rapid metabolism, ethyl glucuronide is the best candidate for monitoring of illicit administration to performance horses.
Heather K. Knych   +4 more
wiley   +1 more source

Toxicological Analysis of Some Drugs of Abuse in Biological Samples [PDF]

open access: yes, 2015
Consumption of drugs of abuse is a scourge of modern world. Abuse, drug addiction and their consequences are one of the major current problems of European society because of the significant repercussions in individual, family, social and economic level ...
Baconi, Daniela Luiza   +5 more
core   +2 more sources

Home - About - Disclaimer - Privacy