Results 171 to 180 of about 117,043 (340)
Drug Testing and Analysis, EarlyView.The novel lysergamide 1‐(furan‐2‐carbonyl)‐LSD (1F‐LSD) was analytically characterized. 1F‐LSD showed LSD‐like activity in vivo similar to 1‐(thiophene‐2‐carbonyl)‐LSD (1T‐LSD) used for comparison. Administration studies in mice and LC–MS analysis revealed that 1F‐LSD served as a prodrug.
Simon D. Brandt +5 more
wiley +1 more source
Cytotoxic and Apoptotic Effects of 17α-Ethynylestradiol and Diethylstilbestrol on CHO-K1 Cells
Food Technology and Biotechnology, 2011 There is considerable concern about the substances present in the environment and their potential to interfere with the endocrine system of vertebrates.
Višnja Gaurina Srček +6 more
doaj
Drug Testing and Analysis, EarlyView.Scenarios of drug exposure and administration as well as detection assays for drugs and methods of sports doping published between 2023 and 2024 are critically reviewed and evaluated in context with the Prohibited List 2024 as established by the World Anti‐Doping Agency.
Mario Thevis +2 more
wiley +1 more source
Ibis, Volume 165, Issue 1, Page 142-152, January 2023., 2023 Dichlorodiphenyltrichloroethane (DDT) is a pesticide that was commonly used for decades worldwide. The use of DDT was banned in the 1970s and 1980s in Europe because of its high toxicity and persistence in the environment, bioaccumulation in living organisms and biomagnification through food webs.
Alazne Díez‐Fernández +6 more
wiley +1 more source
Drug Testing and Analysis, EarlyView.Microbial biotransformation and stability of deschloroketamine derivatives and their metabolites in WW by incubating parent compounds, rat urine, or rat feces showed that deschloroketamine parents and Phase I metabolite were still detectable and that Phase II metabolites decreased in peak areas.
Fabian Frankenfeld +2 more
wiley +1 more source
Drug Testing and Analysis, EarlyView.Another Chinese generic ban‐evading SCRA, CH‐FUBBMPDORA, has emerged. This study reports its first identification in Europe, its analytical characterization (NMR, Raman, FTIR, GC–MS, and HRMS), its cannabinoid activation potential in a βarr2 recruitment assay, and its metabolization profile.
Marie H. Deventer +13 more
wiley +1 more source
The role of biotransformation in chemical-induced liver injury.
, 1976 J. Mitchell +2 more
openalex +1 more source
Effects of the Dietary Supplement 5α‐Hydroxy‐Laxogenin in the Orchiectomized Rat Model
Drug Testing and Analysis, EarlyView.The dietary supplement ingredient 5α‐hydroxy‐laxogenin was investigated in the castrated male rat for potential androgenic and anabolic effects. Moreover, androgen receptor binding of 5α‐hydroxy‐laxogenin was modelled by in silico docking. While molecular modelling supports androgen receptor binding, we observed neither androgenic nor anabolic effects ...
Daniel Derwand +4 more
wiley +1 more source
An investigation into an outbreak of pancytopenia in cats in the United Kingdom
Journal of Veterinary Internal Medicine, Volume 37, Issue 1, Page 117-125, January/February 2023., 2023 Abstract Background In spring 2021 increasing numbers of cats presenting with severe pancytopenia were noted in United Kingdom (UK). Objective To describe process and outcome of the investigation performed into the outbreak of pancytopenia in cats.
Barbara Glanemann +3 more
wiley +1 more source
Environmental and Molecular Mutagenesis, EarlyView.Abstract Gene expression biomarkers have the potential to identify genotoxic and non‐genotoxic carcinogens, providing opportunities for integrated testing and reducing animal use. In August 2022, an International Workshops on Genotoxicity Testing (IWGT) workshop was held to critically review current methods to identify genotoxicants using ...
Roland Froetschl +14 more
wiley +1 more source