Results 181 to 190 of about 117,043 (340)

Xenobiotic Biotransformation in Livestock: Comparison to Other Species Commonly Used in Toxicity Testing1 [PDF]

, 1986
John B. Watkins, Curtis D. Klaassen
openalex   +1 more source

Review of Transcriptomic Biomarkers That Predict In Vitro Genotoxicity in Human Cell Lines

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT The current genotoxicity testing paradigm provides little mechanistic information, has poor specificity in predicting carcinogenicity in humans, and is not suited to assessing a large number of chemicals. Genomic technologies enable the characterization of genome‐wide transcriptional changes in response to chemical treatments that can inform ...
Heng‐Hong Li, Jiri Aubrecht, Tatyana Y. Doktorova, Danyel Jennen, J. Christopher Corton, Roland Froetschl, Roman Mezencev, Carole L. Yauk   +7 more
wiley   +1 more source

Absorption, Excretion, and Biotransformation of Dimethyl Sulfoxide in Man and Miniature Pigs After Topical Application as an 80% Gel

, 1971
Keith Wong, Geng Mei Wang, Jacques Dreyfuss, Eric C. Schreiber   +3 more
openalex   +1 more source

An Enhanced Metabolization Protocol for In Vitro Genotoxicity Assessment of N‐Nitrosamines in Mammalian Cells

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT N‐Nitrosamines (NAs) are probable human carcinogens and were detected as impurities in pharmaceuticals, which led to a concern for human health. NAs require metabolic activation before they become mutagenic, and not all NAs are mutagenic since their reactivity is related to their structure.
M. E. Geijer, A. M. Gernaat, N. Moelijker, I. Brandsma, G. Hendriks   +4 more
wiley   +1 more source

Assessment of Biotransformation Rates, Biomagnification, and Bioconcentration Factors of Difficult-to-Test Substances Using In Vitro Rainbow Trout Liver Subcellular Fractions. [PDF]

Environ Sci Technol
Cantu MA, Chee B, Cole TR, Lee YS, Gobas FAPC.   +4 more
europepmc   +1 more source

Mucosal biotransformation rates in the small intestine of children. [PDF]

, 1988
M.‐R. Ståhlberg, Eino Hietanen, Markku Mäki   +2 more
openalex   +1 more source

Intestinal microbiome alterations in pediatric epilepsy: Implications for seizures and therapeutic approaches

Epilepsia Open, EarlyView.
Abstract The intestinal microbiome plays a pivotal role in maintaining host health through its involvement in gastrointestinal, immune, and central nervous system (CNS) functions. Recent evidence underscores the bidirectional communication between the microbiota, the gut, and the brain and the impact of this axis on neurological diseases, including ...
Teresa Ravizza, Greta Volpedo, Antonella Riva, Pasquale Striano, Annamaria Vezzani   +4 more
wiley   +1 more source

Biotransforming the "Forever Chemicals": Trends and Insights from Microbiological Studies on PFAS. [PDF]

Environ Sci Technol
Skinner JP, Raderstorf A, Rittmann BE, Delgado AG.   +3 more
europepmc   +1 more source

Action of proteolytic enzymes on lipotropins and endorphins: Biosynthesis, biotransformation and fate [PDF]

, 1984
J.P.H. Burbach
openalex   +1 more source

Differential biotransformation ability may alter fish biodiversity in polluted waters

Environment International
Divergence in the activity of biotransformation pathways could lead to species sensitivity differences to chemical stress. To explore this hypothesis, we evaluated the biotransformation capacity of five fish species representative of Swiss biodiversity ...
Marco E. Franco, Juliane Hollender, Kristin Schirmer   +2 more
doaj