Characterization of a Thermophilic and Acidophilic GH78 α-L-Rhamnosidase from <i>Thermotoga</i> sp. 2812B Capable of Efficiently Hydrolyzing a Variety of Natural Flavonoid Diglycosides. [PDF]
Li BC +5 more
europepmc +1 more source
Cannabidiol and cannabigerol suppress maximal electroshock seizures. Cannabidiol and cannabigerol show similar dose–response properties. Both cannabinoids show no toxicity at effective doses. ABSTRACT Current antiseizure therapy for epilepsy is only effective in about 70% of the patient population.
Han Zhong Zhou +3 more
wiley +1 more source
Fungal Biotransformation of Chloroflavanones and Antimicrobial Activity of Parent Compounds and Derived Products. [PDF]
Krawczyk-Łebek A +3 more
europepmc +1 more source
From beginning to end: the synecology of tree‐killing bark beetles, fungi, and trees
ABSTRACT Over a century of research has revealed an amazing complexity of behaviours and physiological adaptations that allow tiny bark beetles to overcome large trees, sometimes resulting in outbreaks that kill millions of trees. Turning a tree into a home and successfully raising offspring involves constant interactions among the beetles, the tree ...
Diana L. Six +3 more
wiley +1 more source
On the Utilization and Characterization of External Biotransformation Systems in <i>In Vitro</i> Toxicology: A Critical Review of the Scientific Literature with Guidance Recommendations. [PDF]
Lungu-Mitea S +7 more
europepmc +1 more source
Pharmacogenomics of Thiopurine Drugs: A Bench‐To‐Bedside Success Story in Thailand
ABSTRACT Thiopurine drugs are the cornerstone treatment for many diseases such as acute lymphoblastic leukemia (ALL), organ rejection, inflammatory bowel disease (IBD), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and other autoimmune diseases.
Mohitosh Biswas +3 more
wiley +1 more source
Metagenomic analysis of bile acid biotransformation by gut microbiota in wild birds. [PDF]
Yang MT +11 more
europepmc +1 more source
ABSTRACT Intrinsic factors such as age and ethnicity influence statin pharmacokinetics (PK) and may increase the risk of muscle‐related adverse events. This study investigated the effect of age on the PK of simvastatin (SV) and its active metabolite, simvastatin acid (SVA), in healthy Thai subjects using an LC–MS/MS assay while accounting for key ...
Thanate Srimatimanon +11 more
wiley +1 more source

