Results 241 to 250 of about 161,017 (342)

Synthesis and In Vitro Metabolic Profiling of the Selective Androgen Receptor Modulator (SARM) LY305

Rapid Communications in Mass Spectrometry, Volume 39, Issue 22, 30 November 2025.
ABSTRACT Rationale 2‐Chloro‐4‐[[(1R,2R)‐2‐hydroxy‐2‐methyl‐cyclopentyl]amino]‐3‐methyl‐benzonitrile (LY305) is a transdermal selective androgen receptor modulator (SARM) that has been under development as a potential therapeutic for conditions involving muscle wasting, osteoporosis, or hypogonadism.
Giorgi Kobidze, Tristan Möller, Hui‐Chung Wen, Francesco Paolo Busardò, Mario Thevis   +4 more
wiley   +1 more source

Bacterial Transformation of Adamantane and Its Derivatives: Regioselectivity and Biocatalytic Approaches. [PDF]

Biology (Basel)
Ivanova AA, Vetrova AA.
europepmc   +1 more source

Effects of Water Source, Suspended Solids, and Acclimation on Biotransformation of 2 /4-Dichlorophenoxy Acetic Acid in Aquatic Systems

, 1985
Christopher K. Moses
openalex   +1 more source

Extensive Biotransformation Profiling of AZD8205, an Anti-B7-H4 Antibody-Drug Conjugate, Elucidates Pathways Underlying Its Stability In Vivo

Yue Huang, Hui Yin Tan, Jiaqi Yuan, Ruipeng Mu, Junyan Yang, Kathryn Ball, Balakumar Vijayakrishnan, Luke A. Masterson, Krista Kinneer, Nadia Luheshi, Meina Liang, Anton I. Rosenbaum   +11 more
openalex   +1 more source

In Vivo Biosynthesis and Direct Incorporation of Noncanonical Amino Acids into Proteins

ChemBioChem, Volume 26, Issue 22, November 17, 2025.
This review evaluates engineered (semi)autonomous cell systems for the biosynthesis and incorporation of noncanonical amino acids (ncAAs) into proteins. While semi‐autonomous cells convert supplied precursors into ncAAs autonomous cells integrate biosynthetic pathways that produce these building blocks intracellularly.
Jan Hendrik Illies, Tim Moritz Weber, Ivana Drienovská   +2 more
wiley   +1 more source

Towards the Use of Metabolic Volatiles in Breath for Determining Drug Response: Gstachamine as an Unlabeled Substrate to Measure CYP3A4 Activity. [PDF]

ChemMedChem
Stock V, Hofer R, Liedl KR, Troppmair J, Langer T, Gstach H, Dank C, Kammerer S, Ruzsanyi V.   +8 more
europepmc   +1 more source

Azaspiracid accumulation, detoxification and biotransformation in blue mussels (Mytilus edulis) experimentally fed Azadinium spinosum

, 2012
Thierry Jauffrais, Claire Marcaillou, Christine Herrenknecht, Philippe Truquet, Véronique Séchet, Élodie Nicolau, Urban Tillmann, Philipp Heß   +7 more
openalex   +2 more sources

Biotransformation of Sulfonamide Antibiotics in Activated Sludge: The Formation of Pterin-Conjugates Leads to Sustained Risk.

Environmental Science and Technology, 2018
Stefan Achermann, V. Bianco, Cresten B. Mansfeldt, Bernadette Vogler, B. Kolvenbach, P. Corvini, K. Fenner   +6 more
semanticscholar   +1 more source

Design and Characterization of Prodrugged Anti‐CTLA‐4 Antibodies

ChemBioChem, Volume 26, Issue 22, November 17, 2025.
Masking an anti‐CTLA‐4 antibody by conjugating a large PEG molecule to specific sites is explored as a way of mitigating undesirable activity in nontarget tissues. This prodrugged antibody exhibits reduced binding to CTLA‐4 and Fc gamma receptors, demonstrated high stability, and had an extended half‐life in a mouse model, potentially improving the ...
Sayumi Yamazoe, Mary Huber, Srikanth Kotapati, Rahima Akter, Aarti Jashnani, Suprit Deol, Christine Bee, John Engelhart, Yam B. Poudel, Stanley Krystek, John Haugner, Mohan Srinivasan, Arvind Rajpal, Yong Zhang, Pavel Strop, Chetana Rao   +15 more
wiley   +1 more source

Biotransformation of Phenolic Acids in Foods: Pathways, Key Enzymes, and Technological Applications. [PDF]

Foods
Lu C, Zhang J, Zhao X, Zi Y, Xiao X.
europepmc   +1 more source