Results 261 to 270 of about 161,017 (342)

Antinociceptive and Anti‐inflammatory Effect of Nicandrin B Isolated From Datura ferox in Zebrafish

Chemistry &Biodiversity, Volume 22, Issue 11, November 2025.
ABSTRACT Nicandrin B (Nic B), a withanolide isolated from Datura ferox leaves, was investigated for its antinociceptive and anti‐inflammatory effects in adult zebrafish (Danio rerio). Animals treated with Nic B (4, 20, and 40 mg/kg) showed no toxicity and maintained normal locomotor activity.
Jéssica Bezerra Maciel, Hortência Ribeiro Liberato, Antônio Wlisses da Silva, Maria Auxiliadora Solange Silva Gondim Pereira, Emanuela de Lima Rebouças, Francisco das Chagas L. Pinto, Matheus Nunes da Rocha, Maria Kueirislene Amâncio Ferreira, Janaina Serra Azul Monteiro Evangelista, Izabel Florindo Guedes, Marcia Machado Marinho, Emmanuel Silva Marinho, Andreia Ferreira de Castro Gomes, Otília Loiola Pessoa, Jane Eire Silva Alencar de Menezes, Hélcio Silva dos Santos   +15 more
wiley   +1 more source

Predicting Micropollutant Removal in Wastewater Treatment Based on Molecular Structure: Benchmark Data and Models. [PDF]

Environ Sci Technol
Cordero Solano JA, Hafner J, McLachlan MS, Singer H, Fenner K.   +4 more
europepmc   +1 more source

Hormonal Regulation of Hepatic Drug Biotransformation and Transport Systems [PDF]

, 2013
María L. Ruiz, Aldo D. Mottino, Viviana A. Catania, Mary Vore   +3 more
openalex   +1 more source

Cobalamin‐Dependent Aryl Methyl Ether O‐Demethylases: Promising Enzymes for Biocatalytic Applications from Lignin Valorization to Organic Synthesis

ChemCatChem, Volume 17, Issue 21, November 10, 2025.
Cobalamin‐dependent aryl methyl ether O‐demethylases have high potential for biocatalytic applications, including lignin valorization and synthetic chemistry. In this review, we provide a detailed overview of such O‐demethylase systems identified to date from various microorganisms, including their mechanism, substrate scope and selectivity, and ...
Niels Krabbe Johnsen, Santipap Chaiyasarn, Zheng Guo, Jaehong Han, Bekir Engin Eser   +4 more
wiley   +1 more source

Antimicrobial activity of new glycoside derivatives of chloroflavones obtained by fungal biotransformation. [PDF]

Sci Rep
Krawczyk-Łebek A, Żarowska B, Janeczko T, Kostrzewa-Susłow E.   +3 more
europepmc   +1 more source

Characterization of new metabolites from in vivo biotransformation of 2‐amino‐ 3‐methylimidazo[4,5‐f]quinoline in mouse by mass spectrometry

, 2009
Fong‐Fu Hsu, Vijaya M. Lakshmi, Terry V. Zenser   +2 more
openalex   +1 more source

Exposure–Response Analysis for Aripiprazole Once‐Monthly in Patients Diagnosed With Bipolar I Disorder

Clinical Pharmacology in Drug Development, Volume 14, Issue 11, Page 869-878, November 2025.
Abstract Aripiprazole once‐monthly (AOM) is approved for the maintenance monotherapy treatment of bipolar I disorder (BP‐I) in adults. A previously developed population pharmacokinetic model was validated by applying it to data from patients diagnosed with BP‐I.
Xiaofeng Wang, Luann Phillips, Matthew Harlin, Karimah S. Bell Lynum, Frank Larsen, Pedro Such, Jessica Madera‐McDonough, Murat Yildirim, Ric M. Procyshyn, Craig Chepke, Julie Passarell   +10 more
wiley   +1 more source

Biotransformation of Tire-Derived 6PPD and 6PPD-Q in Soil Nematode <i>Caenorhabditis elegans</i>: Unraveling Novel Phosphorylation Products and Distinct Kinetic Profiles. [PDF]

Environ Sci Technol
Wang W, Huang G, Miao F, Zhao Z, Cai Z.
europepmc   +1 more source

Avoid Falsely Accusing Female Athletes Who Use Levonorgestrel of Doping

Drug Testing and Analysis, Volume 17, Issue 11, Page 2159-2163, November 2025.
Levonorgestrel, a hormonal contraceptive, metabolises to 18‐methyl‐19‐noretiocholanolone which is also the main metabolite of the prohibited substance 18‐methyl‐19‐nortestosterone. Analysing for levonorgestrel and/or tetrahydronorgestrel is essential to avoid misinterpreting 18‐methyl‐19‐noretiocholanolone findings.
Alexander Andersson, Anton Pohanka, Mikael Lehtihet, Lena Ekström   +3 more
wiley   +1 more source

Metabolic engineering of <i>Yarrowia lipolytica</i> for enhanced microbial production of medium-chain α, ω-diols from alkanes via CRISPR-Cas9 mediated pathway optimization and P450 alkane monooxygenase overexpression. [PDF]

Front Bioeng Biotechnol
Kim YC, Hwan Choi WY, Kim EJ, Kim BG, Yun H.   +4 more
europepmc   +1 more source