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Rapid Assembly of Unsymmetrically Linked Bis-heterocycles via Palladium Domino Catalysis
Organic Letters, 2023A palladium-catalyzed domino reaction of alkene-tethered oxime esters is reported. This transformation uses an air-stable palladium precatalyst that initiates a Narasaka-Heck reaction, that is interrupted with a Pd(II)-promoted cyclization. Through this methodology, a novel class of unsymmetrical alkyl-linked bis-heterocycles were synthesized in yields
Ramon Arora +2 more
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Novel ionic liquid supported-multicomponent reaction toward chimeric bis-heterocycles
Molecular Diversity, 2012A novel multicomponent reaction between IL-anchored 2-aminobenzoimidazoles, aldehydes, and electron-deficient dienophiles has been explored. The strategy was utilized to develop a rapid parallel synthesis for novel bis-heterocyclic skeleton of benzimidazole-linked dihydropyrimidine on an ionic liquid support.
Chih-Hau, Chen +3 more
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Synthesis and antimicrobial activity of bis-heterocyclic sulfamoyl acetamides
Research on Chemical Intermediates, 2014A new class of bis-heterocyclic sulfamoyl acetamides was prepared and studied their antimicrobial activity. The chloro substituted thiazolyl imidazolylsulfamoyl acetamide 6i is found to be a potential antimicrobial agent against Pseudomonas aeruginosa and Penicillium chrysogenum.
K. Divya +3 more
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Bischalcones—synthons for a new class of bis(heterocycles)
New J. Chem., 2004Novel oxo-linked bis(heterocycles) containing two different heterocyclic rings, viz. pyrroles in combination with pyrazolines and isoxazolines, are synthesized.
Venkatapuram Padmavathi +2 more
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Bischalcones — Synthons for a New Class of Bis(heterocycles).
ChemInform, 2005AbstractFor Abstract see ChemInform Abstract in Full Text.
Venkatapuram Padmavathi +2 more
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Discovery of Thiazole Based Bis Heterocyclic System for Anti- Inflammatory Potential
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 2018We have developed a new series of 36 substituted thiazole derivatives prepared via reaction of substituted benzothiazole-2-amine with substituted phenacyl bromide.This study was aimed to develop and successfully evaluate anti-inflammatory activity of substituted thiazole derivatives.A new series of 36 substituted thiazole derivatives was synthesized ...
Amit S, Tapkir +2 more
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A Serendipitous Synthesis of Bis-Heterocyclic Spiro 3(2H)-Furanones
The Journal of Organic Chemistry, 2016(Z) Enol triflates 6, 11b-d, (E) enol triflate 11e, and phenol triflate 11a, derived from β-keto esters or 2-carboalkoxy phenols, respectively, react with N-Boc 2-lithiopyrrolidine (5a), N-Boc N-methylaminomethyllithium (5b), or 2-lithio-1,3-dithiane (14) to afford 3(2H)-furanones in modest to good yields (38-81%). Product and carbanion reagent studies
Alfredo, Picado +2 more
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Novel Synthesis of 1,4-Phenylene Bridged Bis-Heterocyclic Tropone Compounds
HETEROCYCLES, 2012Nucleophilic cyclization reaction of bis(tropolone) derivative (III), which is obtained by Claisen-Schmidt condensation between terephthalaldehyde (I) and acetyltropolone (II), with bifunctional agents such as substituted phenylhydrazine hydrochlorides (IV) and hydroxylamine hydrochloride gives rise to formation of the desired 1,4-phenylene bridged bis-
Wentao Gao, Yang Li, Feng Li
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ChemInform Abstract: Synthesis of Some New Pyridine‐2,6‐bis‐heterocycles.
ChemInform, 2012AbstractDisubstituted pyridines with functionalized azole and azine moieties are synthesized by reaction of the multifunctional, hitherto unknown pyridine derivative (III) with 1,2‐ or 1,3‐binucleophiles including amino‐substituted heterocycles.
Korany A. Ali +2 more
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A Photodimerisation Route to Space-Separated Bis-Heterocycles
1998The photodimerisation of cyclobutene-1,2-diesters has been employed to prepare novel bis-heterocycles containing the following range of subunits: b-lactam (38, 39, 42, 43, 48, 49), dimethoxypyrimidines (29-32), acyl proline (56), 7-oxanorbornene (18) and dipyridylpyridazine ligand (20).
Golić, Mirta +3 more
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