Cloning and Overexpression of Strictosidine β-D-Glucosidase Gene Short Sequence from Catharanthus roseus in Escherichia coli [PDF]
Advanced Pharmaceutical Bulletin, 2019 Purpose: Strictosidine-β-D-glucosidase (SGD) is considered as a key enzyme in the production of bisindole alkaloids in Catharanthus roseus. The present study illustrated the production of a short sequence of this enzyme in Escherichia coli without codon ...
Ahmed Saeed Arafa +4 more
doaj +1 more source
Biotransformation Of l‐Tryptophan To Produce Arcyriaflavin A With Pseudomonas putida KT2440
ChemBioChem, Volume 24, Issue 23, December 1, 2023., 2023 Arcyriaflavin A was produced in Pseudomonas putida KT2440 using genes from Lentzea aerocolonigenes. Cultivation conditions and supply of the precursor l‐tryptophan were optimized. Genetic engineering of outer membrane vesicle release and cultivation with polyurethane adsorbent resulted in product enrichment in the supernatant.
Nora Lisa Bitzenhofer +3 more
wiley +1 more source
Electrophilic carbonyl activation: competing condensative cyclizations of tryptamine derivatives [PDF]
, 2014 A series of tryptamine derived bisindole substrates were subjected to electrophilic activation of the func-tional grouping at their [alpha]-nitrogen in the form of iminium ions to enable cyclization onto the sterically hindered indole substructure.
Liu, Fan, Movassaghi, Mohammad
core +1 more source
Halophiles and Their Biomolecules: Recent Advances and Future Applications in Biomedicine [PDF]
, 2020 The organisms thriving under extreme conditions better than any other organism living on Earth, fascinate by their hostile growing parameters, physiological features, and their production of valuable bioactive metabolites.
Amoozegar, Mohammad Ali +2 more
core +1 more source
In vitro and in vivo antimalarial and cytotoxic activity of five plants used in Congolese traditional medicine. [PDF]
, 2010 peer reviewedAIM OF THE STUDY: The in vitro antiplasmodial activity and cytotoxicity of methanolic and dichloromethane extracts from five Congolese plants were evaluated. The plants were selected following an ethnobotanical survey conducted in D.R. Congo
Angenot, Luc +7 more
core +1 more source
Marine Drugs, 2019 The composition of the culture medium has great influence on the metabolite production of the marine fungus Pseudallescheria boydii F44-1. By adding amino acids to GPY culture medium, two new bisindole alkaloids, pseudboindoles A and B (1 and 2 ...
Mei-Xiang Yuan +7 more
doaj +1 more source
Alkaloids from marine ascidians [PDF]
, 2011 About 300 alkaloid structures isolated from marine ascidians are discussed in term of their occurrence, structural type and reported pharmacol. activity.
FATTORUSSO, ERNESTO +2 more
core +3 more sources
Role of Natural Products in Developing Novel Anticancer Agents: A Perspective
Chemistry &Biodiversity, Volume 19, Issue 11, November 2022., 2022 Abstract Cancer is a heterogeneous disease and is one of the significant health issues, especially in public health systems around the world. Natural products and their structural derivatives with outstanding chemical diversity have been investigated for potential anti‐cancer agents. Many natural products revealing potential anti‐cancer properties such
Baji Baba Shaik +2 more
wiley +1 more source
Facilitating biomimetic syntheses of borrerine derived alkaloids by means of flow-chemical methods [PDF]
, 2015 Flow chemistry is widely used nowadays in synthetic chemistry and has increasingly been applied to complex natural product synthesis. However, to date flow chemistry has not found a place in the area of biomimetic synthesis.
Kamptmann, SB, Ley, SV
core +1 more source
Natural AChE inhibitors from plants and their contribution to Alzheimer´s disease therapy [PDF]
, 2013 As acetylcholinesterase (AChE) inhibitors are an important therapeutic strategy in Alzheimer's disease, efforts are being made in search of new molecules with anti-AChE activity.
Alza, Natalia Paola +4 more
core +2 more sources