Molecules, 2020 A new iboga-vobasine-type isomeric bisindole alkaloid named voacamine A (1), along with eight known compounds—voacangine (2), voacristine (3), coronaridine (4), tabernanthine (5), iboxygaine (6), voacamine (7), voacorine (8) and conoduramine (9)—were ...
Smith B. Babiaka +11 more
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Synthetic Analogues of the Snail Toxin 6-Bromo-2-mercaptotryptamine Dimer (BrMT) Reveal That Lipid Bilayer Perturbation Does Not Underlie Its Modulation of Voltage-Gated Potassium Channels [PDF]
, 2018 Drugs do not act solely by canonical ligand–receptor binding interactions. Amphiphilic drugs partition into membranes, thereby perturbing bulk lipid bilayer properties and possibly altering the function of membrane proteins.
Aldrich, Richard W. +12 more
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Protein & Cell, 2018 Lysosomes are degradation and signaling centers within the cell, and their dysfunction impairs a wide variety of cellular processes. To understand the cellular effect of lysosome damage, we screened natural small-molecule compounds that induce lysosomal ...
Yang Li +13 more
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Circular dichroism calculation for natural products [PDF]
, 2013 Determination of the absolute configuration (AC) is often a challenging aspect in the structure elucidation of natural products. When chiral compounds possess appropriate chromophore(s), electronic circular dichroism (ECD) may provide a powerful approach
Alfarius Eko Nugroho, Hiroshi Morita
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Structure Elucidation and the Antimalarial Activity of Indole Alkaloids from Tabernaemontana macrocarpa Jack [PDF]
, 2021 星薬科大学博士（薬科学）doctoral ...
AMELIA, Puteri
core
Cell type matters: competence for alkaloid metabolism differs in two seed-derived cell strains of Catharanthus roseus [PDF]
, 2022 Since the discovery of the anticancer drugs vinblastine and vincristine, Catharanthus roseus has been intensively studied for biosynthesis of several terpene indole alkaloids (TIAs).
Bunzel, Mirko +7 more
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Antibacterial activities of selected edible plants extracts against multidrug-resistant Gram-negative bacteria [PDF]
, 2013 BACKGROUND: In response to the propagation of bacteria resistant to many antibiotics also called multi-drug resistant (MDR) bacteria, the discovery of new and more efficient antibacterial agents is primordial.
Aimé G Fankam +7 more
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Recent Advances in Drug Discovery from South African Marine Invertebrates
Marine Drugs, 2015 Recent developments in marine drug discovery from three South African marine invertebrates, the tube worm Cephalodiscus gilchristi, the ascidian Lissoclinum sp. and the sponge Topsentia pachastrelloides, are presented.
Michael T. Davies-Coleman +1 more
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Photochemical Approaches to Complex Chemotypes: Applications in Natural Product Synthesis. [PDF]
, 2016 The use of photochemical transformations is a powerful strategy that allows for the formation of a high degree of molecular complexity from relatively simple building blocks in a single step. A central feature of all light-promoted transformations is the
Kärkäs, Markus D. +2 more
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Natural products as novel scaffolds for the design of glycogen synthase kinase 3β inhibitors [PDF]
, 2022 Introduction: The different and relevant roles of GSK-3 are of critical importance since they deal with development, metabolic homeostasis, cell polarity and fate, neuronal growth and differentiation as well as modulation of apoptotic potential.
Andrisano V. +7 more
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