First De Novo Synthesis of the Bisindole Alkaloid Vinblastine.
ChemInform, 2002 AbstractFor Abstract see ChemInform Abstract in Full Text.
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Circular dichroism studies of bisindole Vinca alkaloids
Tetrahedron, 1998 Abstract The analysis of a series of seventeen vinblastine analogs by circular dichroism is described. Exciton coupling of the indole and indoline chromophores of these compounds provides a general, non-empirical method for the assignment of the C16′ configuration with the bioactive C16′-S and the inactive C16′-R analogs giving rise, respectively, to
Craig A. Parish +5 more
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Immunological exploration based studies on Strychnos nux-vomica regarding antigen specific immune response [PDF]
, 2019 In an effort to determine its cytotoxicity as well as antigen specific immune activity of aqueous leaves extract of Strychnos nux-vomica using hepatitis B vaccine containing surface antigen (HBsAg; 20 µg/ml) pertaining to antibody production and ...
Gupta, Amit Joginder
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Phosphorus-sulfur heterocycles incorporating an O-P(S)-O or O-P(S)-S-S-P(S)-O scaffold : one-pot synthesis and crystal structure study [PDF]
, 2017 The authors are grateful to the University of St Andrews for financial support.A new one-pot preparative route was developed to synthesize novel organophosphorus sulfur heterocycles via the reaction of the four-membered ring thionation reagent [2,4 ...
Cordes, David B. +5 more
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Gas Chromatography-Mass Spectrometry (GC-MS) Analysis of Indole Alkaloids Isolated from Catharanthus roseus (L.) G. Don Cultivated Conventionally and Derived from In vitro Cultures [PDF]
, 2016 Catharanthus roseus (periwinkle) is a medicinal plant commonly known for its wide biological activity. In many countries different parts of this plant are used for the treatment of diabetes, hypertension and for menstrual regulation.
GRZESZCZUK, Monika +3 more
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Rare Bisindole Alkaloids from the Amazonian Tree Raputia simulans
Chemistry & Biodiversity, 2014 AbstractThe stem bark of Raputia simulans (Rutaceae) has been reported to contain simple and dimeric indole alkaloids. Further phytochemical investigation of R. simulans stem bark resulted in the isolation of three new alkaloids. These compounds represent a relatively new category of dimeric indole alkaloids with a cyclohexene moiety in their core ...
Vougogiannopoulou, K. +3 more
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Radical mediated heterocycle functionalization: methodology development and natural product synthesis [PDF]
, 2015 Substituted heterocycles are common building-blocks for biologically relevant molecules and represent challenging synthetic targets. Due to limited methods available for their preparation and derivatization, direct C-H functionalization protocols offer ...
Furst, Laura
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Fishing for Targets of Alien Metabolites: A Novel Peroxisome Proliferator-Activated Receptor (PPAR) Agonist from a Marine Pest [PDF]
, 2018 Although the chemical warfare between invasive and native species has become a central problem in invasion biology, the molecular mechanisms by which bioactive metabolites from invasive pests influence local communities remain poorly characterized.
Amodeo, Pietro +21 more
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Synthesis of 3,6-Bis(5’-bromo-3’-indolyl)-1,4-dimethypiperazine-2,5-dione [PDF]
, 2009 The one-pot synthesis of 3,6-bis(5’-bromo-3’-indolyl)-1,4-dimethylpiperazine- 2,5-dione is reported. Sarcosine anhydride is brominated and immediately reacted with 5-bromoindole to produce the product, which is characterized by 1H NMR, MS and ...
Crooke, Stephen N. +2 more
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Exploring the production of high-value compounds in plant Catharanthus roseus hairy roots and yeast Yarrowia lipolytica [PDF]
, 2017 This dissertation focuses on studying the production of two categories of high-value compounds in bio organisms. The first group is terpenoid indole alkaloids (TIAs) in plant Catharanthus roseus, and the second group is wax esters, one of fatty acid ...
Zhao, Le
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